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Journal : Jurnal Media Sains

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Pengaruh pH dan Konsentrasi Terhadap Enkapsulasi Metformin HCl pada Monmorillonit Teraktivasi Asam Sitrat Sitanggang, Katrin Walensky; Suarya, Putu; Simpen, I Nengah; Adhi Putra, I Made Wisnu
Jurnal Media Sains Vol 1, No 2 (2017): JURNAL MEDIA SAINS
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (506.674 KB) | DOI: 10.36002/jms 3.v1i2.259

Abstract

ABSTRAKMonmorillonit telah banyak digunakan sebagai pembawa beberapa jenis obat. Dalam penelitian ini, metformin HCl dienkapsulasi pada monmorillonit alam pada pH yang berbedabeda(3 ? 10) dan konsentrasi larutan metformin HCl yang bervariasi (50 ? 500 mg/L). Sebelumenkapsulasi, monmorillonit alam diaktivasi terlebih dahulu menggunakan asam sitrat 1 N. Spektrofotometer FTIR, diffraktometer sinar-X, and N?Sorption Analyzer digunakan untukmengkarakterisasi material hasil aktivasi. Hasil penelitian menunjukkan jumlah metformin HClyang terenkapsulasi secara maksimum terjadi pada pH 7.? Uji pengaruh konsentrasi larutan awalmenunjukkan bahwa semakin tinggi konsentrasi larutan, semakin banyak metformin HCl yangterenkapsulasi pada monmorillonit teraktivasi. Jumlah maksimum metformin HCl yangterenkapsulasi teramati pada konsentrasi larutan 500 mg/L. Luas permukaan dan volume porimonmorillonit alam ditemukan menurun setelah aktivasi menggunakan asam sitrat. Analisis 2menggunakan FTIR menunjukkan pergeseran puncak-puncak serapan monmorillonit setelahaktivasi dengan asam sitrat. Pergeseran puncak difraksi tidak teramati pada pola difraksi sinar-Xyang mengindikasikan kristalinitas monmorillonit tetap terjaga meskipun setelah diaktivasidengan asam sitrat.Kata kunci: monmorillonit, metformin HCl, pH, konsentrasi awal, enkapsulasi, sistem penghantar obat?ABSTRACTMontmorillonite has been widely used as a carrier of several drugs.? In this research, metformin HCl was encapsulated on natural monmorillonite on various pH (3 ? 10) andconcentration of metformin HCl (50-500 mg/l). Natural montmorillonite was activated by citricacid 1 N prior to encapsulation process. FTIR Spectrophotometer, X-ray diffractometer, and NSorption Analyzer were used to characterize the materials. The results showed that the highestamount of metformin HCl encapsulated on natural monmorillonite was occurred at pH of 7. Theeffect of initial concentration showed that the higher the concentration of metformin HCl, the greater the amount of drugs encapsulated on activated monmorillonite. The maximum amount of drug encapsulated was occurred at initial concentration of 500 mg/L. The surface area andpore volume of natural monmorillonite were found to be decrease after activation using citricacid. Analysis using FTIR confirmed the dislocation of absorption peaks after activation withcitric acid. However, the dislocation of diffraction peaks are not observed in XRD pattern,indicated the there were no changes in the crystallinity of monmorillonit after activation. Key words: monmorillonite, metformin HCl, pH, initial concentration, encapsulation, drug delivery system.
Co-Authors A A I Rahma Prabawanti A.A. B. Putra Anak Agung Gde Raka Dalem Anastasia Victor, Agnes Maria Salvi Arsa Arsa D. A. D. N. Dewi D.M Priyantha Wedagama Dewik Setiyawati Dwi Adhi S, Ni Gusti Ayu Made Dwi Anggraeni Putri Suandi Ewa Satriawijaya Febby Hartesa W G M Arya Sasmita G.M.A. Sasmita Gunawan, A. A. Ngurah Gusti Ngurah Sutapa Hudi Nurwendi I Gde Antha Kasmawan I Gede Andy Andika Parahita I Ketut putra, I Ketut I M. S. Negara I M. S. Negara I M. S. Negara I M. Trimastiya I Made Dupi Andika I Made Sutha Negara I Made Sutha Negara I Made Wisnu Adhi Putra I Nengah Artawan I Nengah Sandi I Nyoman Aribudiman I Nyoman Sumerta Miwada I Nyoman Suprapta Winaya I NYOMAN SUTARPA SUTAMA I Nyoman Widana I W BUDIARSA SUYASA I Wayan Redana I Wayan Suarsa I Wayan Sudiarta I Wayan Suditayasa I. M. S. Negara I.A.G. Widihati I.A.G. Widihati I.M.S. Negara Ida Ayu Agung Pradnyani Ida Bagus Made Suryatika Ika Umratul IM.S. Negara Ketut Gede Dharma Putra Komang Yogi Purnamawati M. Arsa M. Indra Dwitama M. W. Prayani Made Indra Dwitama Made Suryatika, Ida Bagus Muhammad Nasib N. K. A. Oktapiani N. K. D. Astuti N.M. Puspa wati Nanik Ayumi Ni G. A. M. Dwi Adhi Suastuti Ni Ketut Suminten Ni Komang Tria Paramita Septiari Ni LUH ARPIWI Ni Luh Eka Anggarayanti Ni Luh Nyoman Kebayantini Ni Luh Putu Suciptawati Ni Made Puspawati Ni Made Widya Pratiwi Ni Nyoman Pujianiki Ni Nyoman Rupiasih Ni Putu Diantariani Ni Putu Gita Bonita Dewi Ni Putu Widya Tironika Dewi Ni Wayan Trisnadewi, Ni Wayan Nurmalasari, Ni Putu Yuni O. Ratnayani O. Ratnayani O. Ratnayani Oka Ratnayani Olivia Carolyn Sitepu Prawistya Putra, I Made Gede Mas Putra Adnyana, I Gusti Agung Putra, Anak Agung Bawa Putu Suarya R. Dalem S. R. Mustikawati Sihotang, Erikson Sihotang, I Nyoman Silalahi, Dio Carpry Gunawan Sitanggang, Katrin Walensky Siti Helmyati Siti Zulaikah Sri Rahayu Santi Tri Lestari, Komang Ayu W. A. Fauzi Y. N. Handayani Y. Ulfa