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All Journal HAYATI Journal of Biosciences Medicina journal of internal medicine E-Jurnal Medika Udayana Jurnal Penyakit Dalam Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico KESANS : International Journal of Health and Science GANESHA MEDICINA Hang Tuah Medical Journal Eduvest - Journal of Universal Studies Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)

I Made Pande Dwipayana

Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Denpasar, Bali, Indonesia

Author-ID : 2936391

Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Title

Seorang penderita tiroiditis hashimoto dan kaitannya dengan riwayat utikaria kronis serta keganasan rahim I Komang Realiska; I Made Pande Dwipayana
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Background: Hashimoto's thyroiditis (TH) is a spectrum of autoimmune diseases in the presence of a thyroid. The spectrum begins pathologically from auto-antibodies that attack the thyroid tissue and progress to fibrosis.Case report: A 28-year-old woman diagnosed with Hashimoto's Thyroiditis (TH) and a history of chronic urticaria and uterine malignancies. Thyroid hormone profile examination showed primary abnormalities thyroid by autoimmune with TSH 8.63 (0.25-5.00) ?IU / mL, FT4 1.06 (0.93-1.70) ng / dL, and anti-thyroid peroxidase (anti-TPO) 3155.38 IU / mL. Thyroid ultrasound examination showed increased parenchymal vascularization, no nodules or cysts, calcifications. Histopathological examination revealed a lymphocytic thyroiditis process—management of patients given levothyroxine, achieve the appropriate clinical resolution and therapeutic targets.Conclusion: Chronic urticaria condition and uterine malignancy history in patients are suspected to be related to TH. Based on the cycle model theory of autoimmunity and carcinogenesis, malignancy can cause activated immune response, and loss of self-tolerance occurs as induction of autoimmune processes and vice versa inflammation in autoimmune induces malignancy.Latar Belakang: Tiroiditis Hashimoto (TH) merupakan salah satu spektrum penyakit autoimun pada kelenjar tiroid. Spektrum ini dimulai secara patologi dari terbentuknya auto-antibodi yang menyerang jaringan tiroid, dan berpogresif menjadi fibrosis.Laporan kasus: Seorang wanita 28 tahun dengan diagnosa Tiroiditis Hashimoto (TH) dan riwayat urtikaria kronis dan keganasan rahim. Pemeriksaan profil hormon tiroid menunjukkan kelainan primer kelenjar tiroid oleh autoimun dengan TSH 8.63 (0.25-5.00) ?IU/mL, FT4 1.06 (0.93-1.70) ng/dL, dan anti-thyroid peroxidase (anti-TPO) 3155.38 IU/mL. Pemeriksaan USG tiroid menunjukkan peningkatan vaskularisasi parenkim, tak tampak nodul/kista, ataupun kalsifikasi. Pemeriksaan histopatologi menunjukkan proses limphocytic thyroiditis. Tatalaksana pada pasien diberikan levotiroksin yang mencapai resolusi klinis dan target terapi yang sesuai.Simpulan: Pasien memiliki riwayat keganasan rahim yang diasosiasikan dengan TH. Berdasarkan teori cyclic model of autoimmunity and carcinogenesis mengatakan keganasan dapat menyebabkan teraktivasi respons imun dan terjadi self-tolerance sebagai induksi dari proses autoimun dan sebaliknya inflamasi yang terjadi pada autoimun menginduksi keganasan.

Analisis faktor resiko yang berhubungan dengan nilai Neutrophil Lymphocyte Ratio (NLR) tinggi pada pasien diabetes mellitus tipe 2 yang terinfeksi COVID-19 di Rumah Sakit Umum Pusat (RSUP) Sanglah, Bali, Indonesia Marisye Christantia; Made Ratna Saraswati; Anak Agung Gde Budhiarta; Ketut Suastika; I Made Pande Dwipayana; I Made Siswadi Semadi; Ida Bagus Aditya Nugraha
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i3.1340

Background: Coronavirus disease (COVID-19) infection has become a worldwide pandemic. Diabetes Mellitus is a comorbid disease that can increase in severity. The most common clinical finding in severe COVID-19 infection is a high Neutrophil Lymphocyte Ratio (NLR). In patients with Diabetes Mellitus (DM) type 2, it is also known that high NLR values have a poor prognosis. This study analyzes the risk factors associated with high NLR values in type 2 DM patients infected with COVID-19 at Sanglah General Hospital. Methods: A cross-sectional analytical study was conducted on the medical records of 70 patients with COVID-19 infection with type 2 DM who were treated at Sanglah General Hospital, Denpasar, for the period April 2020-October 2020. The samples were divided into two groups, namely high and normal NLR. The analysis was conducted to see which risk factors were significantly associated with high NLR values in COVID-19 patients with type 2 diabetes. The analysis was carried out using an independent T-test for numerical variables and chi-square for nominal variables. Results: Most of the study samples had high levels of NLR (65.71%). Risk factors that had a significant relationship with high NLR values were random blood sugar levels (p=0.00), fasting blood sugar levels (p=0.00), HbA1c (p=0.002), CRP levels (p=0.00), leukocyte level (p=0.00), BUN level (p=0.004), history of type 2 DM before COVID-19 infection (p=0.009) and control HbA1c (0.001). Conclusion: The risk factors associated with high NLR values in COVID-19 patients with type 2 DM at Sanglah Hospital Denpasar are random blood sugar levels, fasting blood sugar levels, HbA1c, CRP levels, leukocyte levels, BUN levels, history of type 2 diabetes before COVID-19 infection and HbA1c control. Latar Belakang: Infeksi Coronavirus disease (COVID-19) telah menjadi pandemik di seluruh dunia. Diabetes Mellitus merupakan penyakit komorbid yang dapat meningkatkan keparahan. Temuan klinis yang banyak ditemukan pada infeksi COVID-19 berat adalah nilai neutrophil lymphocyte ratio (NLR) yang tinggi. Pada pasien Diebetes Mellitus (DM) tipe 2 juga diketahui nilai NLR yang tinggi memiliki prognosis buruk. Penelitian ini bertujuan untuk menganalisis faktor risiko yang berhubungan dengan nilai NLR tinggi pada pasien DM tipe 2 yang terinfeksi COVID-19 di RSUP Sanglah. Metode: Studi analitik potong lintang dilakukan pada rekam medik 70 pasien dengan infeksi COVID-19 dengan DM tipe 2 yang dirawat di RSUP Sanglah Denpasar periode April 2020-Oktober 2020. Sampel dibagi menjadi dua kelompok yakni NLR tinggi dan normal. Analisis dilakukan untuk melihat faktor risiko yang signifikan berhubungan dengan nilai NLR tinggi pada pasien COVID-19 dengan DM tipe 2. Analisis dilakukan menggunakan uji independent T-test untuk variabel numerik dan chi-square untuk variabel nominal. Hasil: Mayoritas sampel penelitian memiliki kadar NLR tinggi (65,71%). Faktor risiko yang memiliki hubungan signifikan dengan nilai NLR tinggi adalah kadar gula darah acak (p=0,00), kadar gula darah puasa (p=0,00), HbA1c (p=0,002), kadar CRP (p=0,00), kadar leukosit (p=0,00), kadar BUN (p=0,004), riwayat DM tipe 2 sebelum infeksi COVID-19 (p=0,009) dan kontrol HbA1c (0,001). Kesimpulan: Faktor risiko yang berhubungan dengan nilai NLR tinggi pada pasien COVID-19 dengan DM tipe 2 di RSUP Sanglah Denpasar adalah kadar gula darah acak, kadar gula darah puasa, HbA1c, kadar CRP, kadar leukosit, kadar BUN, riwayat DM tipe 2 sebelum infeksi COVID-19 dan kontrol HbA1c.

Hubungan nilai Neutrophil Lymphocyte Ratio (NLR) terhadap parameter laboratorium pada pasien DM tipe 2 yang terkonfirmasi COVID-19 di Rumah Sakit Umum Pusat (RSUP) Sanglah, Bali, Indonesia R. Prawira Bayu Putra Dewa; Made Ratna Saraswati; Anak Agung Gde Budhiarta; Ketut Suastika; I Made Pande Dwipayana; I Made Siswadi Semadi; Ida Bagus Aditya Nugraha
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i2.1345

Background: The pathogenesis of COVID-19 infection is the occurrence of excessive inflammatory reactions in which one of the markers of inflammation that is easy to work with is the value of the Neutrophil Lymphocyte Ratio (NLR). The NLR value increases in uncontrolled type 2 DM patients and is a prognostic factor for the occurrence of severe symptomatic COVID-19 infection. This study aims to examine the correlation between NLR values and various laboratory parameters of type 2 DM patients with COVID-19 infection at Sanglah Hospital. Methods: This study used a cross-sectional analytical design and involved 70 research samples from the medical records of type 2 DM patients with COVID-19 who were treated at Sanglah Hospital from April 2020 to October 2020. Analysis with Pearson and Spearman tests to see the correlation between NLR values and 12 laboratory parameters such as GDS, GDP, HbA1c, Leukocytes, Hemoglobin, BUN, D-Dimer, CRP, serum creatinine, SGOT, SGPT and Ferritin using SPSS software version 21 for Windows. Results: From the results of the correlation test, laboratory parameters that were found to be significantly positively correlated with NLR values were GDS levels (r=0.451; p=0.000), GDP (r=0.037; p=0.001), leukocytes (r=0.479; p=0.000), BUN (r=0.368; p=0002), D-dimer (r=0.348; p=0.011), CRP (r=0.557; p=0.000), serum creatinine (r=0.313; p=0.009) and ferritin (r=0.337; p=0.011). Conclusion: The NLR value in type 2 DM patients with COVID-19 is positively correlated with glycemic markers, namely GDS and GDP. In addition, it is also positively correlated with leukocytes, BUN, D-dimer, CRP, serum creatinine and ferritin. Latar belakang: Patogenesis infeksi COVID-19 adalah terjadinya reaksi inflamasi berlebihan dimana salah satu penanda inflamasi yang mudah dikerjakan adalah nilai Neutrophil Lymphocyte Ratio (NLR). Nilai NLR meningkat pada pasien DM tipe 2 yang tidak terkontrol dan menjadi faktor prognostik untuk terjadinya infeksi COVID-19 gejala berat. Penelitian ini bertujuan untuk meneliti korelasi antara nilai NLR dengan berbagai parameter laboratorium pasien DM tipe 2 dengan infeksi COVID-19 di RSUP Sanglah. Metode: Studi ini menggunakan desain analitik potong lintang dan melibatkan 70 sampel penelitian dari rekam medik pasien DM tipe 2 dengan COVID-19 yang dirawat di RSUP Sanglah bulan April 2020 hingga Oktober 2020. Analisis dengan Uji Pearson dan Spearman untuk melihat korelasi antara nilai NLR dengan 12 parameter laboratorium berupa GDS, GDP, HbA1c, Leukosit, Hemoglobin, BUN, D-Dimer, CRP, serum kreatinin, SGOT, SGPT dan Ferritin menggunakan piranti lunak SPSS versi 21 untuk Windows. Hasil: Dari hasil uji korelasi, parameter laboratorium yang ditemukan signifikan berkorelasi positif dengan nilai NLR adalah kadar GDS (r=0,451; p=0,000), GDP (r=0,037; p=0,001), leukosit (r=0,479; p=0,000), BUN (r=0,368; p=0002), D-dimer (r=0,348; p=0,011), CRP (r=0,557; p=0,000), serum kreatinin (r=0,313; p=0,009) dan ferritin (r=0,337; p=0,011). Kesimpulan: Nilai NLR pada pasien DM tipe 2 dengan COVID-19 berkorelasi positif dengan penanda glikemik yaitu GDS dan GDP. Selain itu berkorelasi positif juga dengan leukosit, BUN, D-dimer, CRP, serum kreatinin dan ferritin.

Co-Authors A Santoso A. A. Putu Eka Darmaputra Juliantara AA Gede Budhiarta, AA Gede AA Istri Sri Kumala Dewi, AA Istri Sri Kumala AAG Budhiarta Aditya Rachman Anak Agung Gde Budhiarta Anak Agung Gde Budhiarta Anak Agung Gede Budhiarta Ari Puji Astiti Bayu Mayura, I Putu Budhiarta, Anak Agung Gde H Taniguchi I Ketut Suastika I Komang Realiska I Made Ady Wirawan I Made Siswadi Semadi I Made Siswadi Semadi I Made Siswadi Semadi I. K. Suastika I.A.A. Widhiartini Ida Bagus Aditya Nugraha Ida Bagus Yorky Brahmantya IGN Gunadi IMR Saraswati Indraguna Pinatih, Gde Ngurah Isabella Soerjanto Putri K Badjra Nadha K Rina Kadek Dina Puspitasari Kartadinata, Sarah Levina Kevin Ezekia Komang Agus Wira Nugraha Made Agus Hendrayana MADE RATNA SARASWATI . Made Wihandani, Desak Made Windha Prajaskari Armi Marisye Christantia Mona Mentari Pagi Surbakti N Kajiwara Nathasia Ni Made Alit Arini Ni Putu Tesi Maratni, Ni Putu Tesi Nila Wahyuni Parastan, Rovie Hikari Putra Sugiharta, Adhika Tri Putu Ayu Suastidewi PUTU SARASWATI LAKSMI DEWI R. Prawira Bayu Putra Dewa Rena, Ni Made Renny Anggreni S., Hantono Siorcani, Putu Tasha Stefani, Lidwina Sutanegara - W Wita Wan Muhamad Syafiq Wardana, Rr. Cattleya Allayka Wira Gotera

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Journal : ISM (Intisari Sains Medis) : Jurnal Kedokteran