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Journal : Jurnal of Syiah Kuala Dentistry Society

The Number of Alveolar Bone Cells Exposed to Zoledronate in the Post-Tooth Extraction Socket Lubis, Septina Sabilla; Palupi, Anggraeny Putri Sekar; Komariah, Komariah; Latief, Benny Syariefsjah; Priosoeryanto, Bambang Pontjo; Suniarti, Dewi Fatma
Journal of Syiah Kuala Dentistry Society Vol 9, No 2 (2024): December 2024
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v9i2.41502

Abstract

Background: Zoledronate is an intravenous bisphosphonate that effectively treats osteoporosis by inhibiting osteoclast resorption, thereby reducing the risk of fractures. However, its use in post-extraction patients may increase the risk of bisphosphonate-related osteonecrosis of the jaws (BRONJ). Objective: This study aims to analyze the effects of zoledronate on alveolar bone structure in Sprague Dawley rats, focusing on changes in osteoblast, osteocyte, and osteoclast counts. Methods: This cross-sectional study employed an observational analytical approach. Samples were categorized based on zoledronate exposure. Osteoblast, osteocyte, and osteoclast counts were measured using ImageJ software at 40x magnification. Data were analyzed using SPSS, with one-way ANOVA employed for statistical analysis. Normality and homogeneity tests were conducted to ensure data validity. Results: Zoledronate exposure resulted in a decrease in osteoblast and osteoclast counts, while osteocyte counts increased. Statistical analysis showed no significant differences between the zoledronate-exposed group and the control group. Conclusion: Zoledronate reduces osteoclasts and increases osteocytes, potentially leading to cellular apoptosis in osteoporosis patients. The risk of BRONJ can be minimized by administering zoledronate at appropriate doses and maintaining optimal oral hygiene to prevent bacterial activity.
Co-Authors . CHURIYAH . Darmawi Adhi Rahmat Hariyadi Aditya Primawidyawan Agus Susanto Ahmad Aulia Ahmad Aulia Andra Hendriarto Andri Hardianto Andri Lubis Andri Prasetiyo Anggraeny Putri Sekar Palupi Anggraini, Lutvi Anissa Canintika Anita Esfandiari Annisa Fitriyana Ardi Sandriya Ari Fahrial Syam Ari Fahrial Syam Aria Kekalih Asri, Lia Amelia Tresna Wulan Aulia Andi Mustika Az Zahra, Shafiyyah Azhari Azhari Bambang Sunendar Purwasasmita, Bambang Sunendar Bayu Febram Bayu Febram Bayu Febram Prasetyo Bethy Suryawathy Hernowo Betty S.L. J Betty Sri Laksmi Jenie Budi Arifin Chudahman Manan Chudahman Manan Dahlia Sutanto Daldiyono Daldiyono Daldiyono Daldiyono Darmawi D Deddy Muchtadi Dede Robiatul Adawiyah Deni Noviana Denny Widaya Lukman Dewi Fatma Suniarti Dewi Ratih Agungpriyono Djarot Sasongko Hami Seno Dwi Kesuma Sari Dyah Sulistyani Rahayu Edy Djauhari Purwakusumah Eka Nurul Qomaliyah Endang Prangdimurt Endang Prangdimurti Endang Sjamsudin Erniati, Erniati Esti Mumpuni Eva Harlina Evy Damayanthi Fachriyan Hasymi Pasaribu Fachriyan Hasymi Pasaribu Fachrul Razi Fadila Raisyadikara Farra Sasmita Franky Oscar, Franky Fransiska R. Zakaria Fransiska Rungkat Zakaria Fransiska Rungkat Zakaria Gatot T. Mulyadi Gatot Trimulyadi Rekso Gunanati Soedjono Gunanti Gunanti . GUSTAF ADOLF WATTIMENA Hamny Sofyan Hartanti Hartanti Hartanti Hartanti, Hartanti Hasim Hasim Hatibie, Mendy Juniaty Hatta, Isnur Herwin Pisestyani Hidayat Syarief Husnawati, . I Made Kardena I Nyoman Suarsana I Nyoman Suartha I Wayan Gorda I wayan Teguh Wibawan IETJE WIENTARSIH Irmanida Batubara Iwan Harjono Utama Jimmy Pangihutan Juliana, Dara Kazuyuki Uchida Koeswinarning Sigit Komariah Komariah Kreshanti, Prasetyanugraheni Kuroki, Yutaka KUSMARDI KUSMARDI Kusumawati, Nina Tri Lanniari, Nafrina Latief, Benny Syariefsjah Latifah Darusman Lilis Nuraida Lina Noviyanti Sutardi Lisni Noraida Lubis, Septina Sabilla Lucky Riawan Lusi Epsilawati Madyastuti, Rini Mahdi Abrar Makmuri Yusuf MARIA BINTANG Maya Shofa Mieke Hemiawati Satari Mieke Hemiawati Satari Mieke Hermiawati Satari Miksusanti Miksusanti Mirnawati Soedarwanto Mirnawati Soedarwanto Mirnawati Soedarwanto Monica Septiani Muharty, Annisya Najmah Najmah Nancy Dewi Yuliana Naoaki Misawa NASRIANTI SYAM, NASRIANTI Nina Kusumawati Nur Fathonah Sadek Nurhidayat - Nurhidayat, Nurhidayat Okabayashi, Tamaki Prangdimurt, Endang Priskila Priskila Putu Angga Wiradana Putu Eka Sudaryatma Rachmi Ridho Rahmadansah Rahmadansah Rahminiwati, Min Rahyussalim Ratna Puspita Rayendra, Raendi Retno Wulansari Rifki Septawendar Riki Siswandi Rimbawan , Rini, Dian Cipta Ripta Mustafa Nugraha Risa Tiuria Riski Rostantinata Riski Rostantinata Rizal Syarief Rizal Syarief Rizki Fitria Rizki Rostantinata Ros Sumarny Rostantinata, Riski Ryoji Yamaguchi Sabri Mustafa Sadek, Nur Fathonah Safrida Safrida Sajida Sajida Samuel Leonardo Silitonga SANTOSO CORNAIN Sarifah, Norlaila Sebayang, Shalina SILMI MARIYA Slamet Budijanto Sri Anna Marliyati Sri Estuningsih Sri Kayati Widyastuti Subangkit, Mawar Sugeng Supriadi, Sugeng Sukasah, Chaula Luthfia Sunardhi Mangundjaja, Sunardhi Surachmi Setiyaningsih Surachmi Setyaninigsih Surya Pangidoan Nasution Suryani Suryani Suryani Suryani Susi Susanah Susumu Tateyama Syamsudin Abdillah Takeshi Katayama Tangkonda, Elisabet Tena Djuartina, Tena Toshisada Suzuki Tri Isyana Tungga Dewi Tri Isyani Tungga Dewi Tungga Dewi, Tri Isyani Tutik Wresdiyati Ummu Balqis Vetnizah Juniantito Wahyuni, Sri Waras Nurcholis Wasmen Manalu Wati, Vivi Septya Weko Adhiarto, Weko Wiranti, Rahayu Woro Yonathan Arderian Mantik Ziad Alaztha