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All Journal Medical Journal of Indonesia Journal of Biomedicine and Translational Research Universa Medicina Makara Journal of Health Research Bioma : Jurnal Ilmiah Biologi
Ria Kodariah
Departemen Patologi Anatomi FKUI
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Bioma : Jurnal Ilmiah Biologi

 1 
T HELPER 17 (Th17) AND REGULATORY T (Treg) CELLS PROFILE IN TYPE-2 DIABETES MELLITUS (T2DM) DWIKARJANTI, INDRANITA; KRISNAMURTI, DESAK GEDE BUDI; KODARIAH, RIA
BIOMA : Jurnal Ilmiah Biologi Vol. 14 No. 1 (2025): April 2025
Publisher : LPPM Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/bioma.v14i1.1208

Abstract

One of metabolic disorder disease is Type 2 Diabetes mellitus (DM), leading to increased glucose, cholesterol, and lipid levels in the blood. Type 2 DM results in insulin resistance within the body. Glycolysis, oxidative phosphorylation, and fatty acid are the three main metabolic pathways which provide energy for T cells. T cells will ploriferate, differentiate and become active into T Helper-17 and T regulator (Treg) cells because of these pathways. The profile of TH-17 cells and Treg cells in type 2 diabetes will be opposite in terms of the number of their populations caused by metabolic disorders in the body. Type 2 diabetes make an immunology response with increasingly number of TH-17 cells, while lack of Treg cells. Many studies have shown that diabetes mellitus as a metabolic disease effect populations of T Helper-17 and regulatory T cells. Glycolysis is the main energy metabolism becomes important factor that stimulate the proliferation and differentiation of Th-17 cells. The energy produced from this metabolism is in the form of ATP, which is the result of glucose synthesis using the Glucose transporter (GLUT). Glucose transporters (GLUT-1) are most dominantly expressed by Th-17 cells and Treg cells. Metabolic disorder causes an imbalance in the population of TH-17 cells with Treg cells. This review will explain the profiles of TH-17 and regulatory T cells in Diabetes mellitus and their relationship with body metabolism disease.
Co-Authors A. N. Kurniawan Antonius N. Kurniawan Averdi Roezin Desak Gede Budi Krisnamurti Dewi Sukmawati Dwi Anita Suryandari DWIKARJANTI, INDRANITA Endang S.R. Hardjolukito Handayani, Astri Hening Pujasari Katsuyuki Aozasa Luluk Yunaini Maria F. Ham Meilania Saraswati Meryanne Elisabeth Puspita Eka Wuyung Septiawan, Aditya D Shin-Ichi Nakatsuka Soehartati Gondhowiardjo Sophie Yolanda Wen-Juan Luo Yayi Dwina Yuda Nabella Prameswari