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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

The Role of Alpha Linolenic Acid on Neuroinflammation: A Systemic Review Wijaya, Debby Chesilya; Linawati, Ni Made
Jurnal Penelitian Pendidikan IPA Vol 10 No 7 (2024): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i7.6173

Abstract

Neuroinflammation, an inflammatory response within the central nervous system (CNS), plays a critical role in various neurological disorders, including neurodegenerative diseases. Alpha linolenic acid (ALA), an essential omega-3 polyunsaturated fatty acid, has shown promising health benefits due to its antioxidant and anti-inflammatory properties. This article aims to thoroughly examine the potential effects of ALA in reducing neuroinflammation, emphasizing its roles as an anti-inflammatory and antioxidant agent. The review focuses on studies published between 2018 and 2023, sourced from reputable academic databases such as PubMed, Semantic Scholar, Google Scholar, and ScienceDirect, with nine key papers selected. The findings indicate that ALA significantly mitigates neuroinflammation by decreasing reactive oxygen species (ROS) via the Nrf-2/HO-1/JNK signaling pathway. Additionally, ALA reduces inflammatory cytokines by inhibiting p-JNK activation, disrupting lipid rafts, blocking the pro-inflammatory transcription factor NF-κB, and altering cell membrane phospholipid composition. The review concludes that ALA may have potential therapeutic effects in reducing neuroinflammation through its antioxidant and anti-inflammatory actions, offering possible benefits for various neurological conditions, including Alzheimer's and Parkinson's diseases.
Co-Authors A.A.A. Biantari Apsari Trinaya ADNYANA PUTRA, I GEDE AGUS DIVA Adnyana, I Made Diatmika Agus Eka Darwinata Ali Djamhuri Amaral, Meriana Barreto Anak Agung Ngurah Subawa Arijana, I G Kamasan Nyoman Arijana, I Gusti Nyoman Kamasan Arijana, I.G Kamasan Nyoman Arijana, IGK Nyoman Bagus Komang Satriyasa Dakshayani Vijayan Dewa Agung Gina Andrini Dewa Ayu Agus Sri Laksemi Dewa Ayu Agus Sri Laksmi Dewa Putu Gede Purwa Samatra Dewi, Pande Putu Ayu Patria Etik Nurhidayati Eugenia Meidy Farmananda, Irsandi Rizki Fedik Abdul Ratam Gede Wirata Harinder Kaur I Dewa Gede Angga Triadi Nata I Dewa Made Agus Paramarta Putra I Gde Haryo Ganesha I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Gusti Nyoman Sri Wiryawan I Gusti Nyoman Sri Wiryawan I Ketut Tunas I Made Jawi I Made Krisna Dinata I MADE MULIARTA . I Made Niko Winaya I Made Sudarmaja I Made Sudarmaja I Nyoman Wande I Nyoman Wande I Putu Dema Prasetya I Wayan Juli Sumadi I Wayan Putu Sutirta Yasa I Wayan Rai Widarta I Wayan Sugiritama I Wayan Sugiritama I Wayan Sugiritama I Wayan Sumardika I.A.A. Widhiartini Ida Ayu Ika Wahyuniari Ida Bagus Putra Manuaba Intan Syahirah Bt Abdul Rauap Irmawan Farindra Jaspreet Kaur Juven Luvianto Ketut Ariawati Komang Ayu Trisnadewi Luh Made Indah Sri Handari Adiputra Luh Made Mas Rusyati Luh Putu Ratna Sundari Luvianto, Juven Muhammad Ashhabul Kahfi Mathar Mulianti, Rizki N. Adiputra Ni Eka Dewi Ambarawati Ni Eka Dewi Ambarawati Ni Kadek Ayu Satya Dewanti Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Luh Rustini Ni Made Mertaniasih Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Nuril Hidayah Nyoman Intan Cahaya Pertiwi Nyoman Pratiwi Hapsari Dewi Putu Ayu Asri Damayanti Putu Ayu Sita Saraswati Putu Diah Pratiwi Radjibu, Gabriela Anastasya Viorezky Rastika, I Gede Agus Ratnayanthi, I Gusti Ayu Dewi Ratnayanti, Gusti Ayu Dewi Raymond Elbert Budianto Riezky Januar Pramitha Ruthirar Kalaichelvam Sawitri, Anak Agung Sagung Sianny Herawati Sidauruk, Dona Uli Sugijanto - Sugijanto - Susy Purnawati Tjokorda Gede Oka Tohjiwa, G. Raditya Vania Lannisa Haestidyatami Wahyuddin, Wahyuddin Wicaksana, I Dewa Agung Gede Oka Dwi Widianti, I Gusti Ayu Widiyanti, I Gusti Ayu Wijaya, Debby Chesilya Wilianto Wilianto Yusuf Nasirudin