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All Journal Medical Journal of Indonesia The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) GERVASI: Jurnal Pengabdian kepada Masyarakat JFIOnline Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Journal of Indonesia Jurnal Jamu Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Narra J Cermin Dunia Kedokteran eJournal Kedokteran Indonesia Journal of Health and Nutrition Research Makara Journal of Health Research Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry Jurnal Kefarmasian Indonesia Indonesian Journal of Jamu Cermin Dunia Kedokteran
Melva Louisa
Departement Of Pharmacology And Therapeutics, Faculty Of Medicine, Universitas Indonesia, Jakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Molecular and Cellular Biomedical Sciences (MCBS)

 1 
Andrographis paniculata Ethanolic Extract Improved Doxorubicin-induced Cardiac Inflammation, Alterations in Liver Function Parameters and Anemia Eziefule, Oluebube Magnificient; Arozal, Wawaimuli; Wanandi, Septelia Inawati; Louisa, Melva; Wuyung, Puspita Eka; Dewi, Syarifah; Nafrialdi, Nafrialdi; Dewi, Yulia Ratna; Nabillah, Deya Adiby
Molecular and Cellular Biomedical Sciences Vol 8, No 2 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i2.444

Abstract

Background: Doxorubicin (DOX), an efficacious chemotherapy drug is compromised by cardiotoxicity, myelosuppression, and hepatotoxicity. Due to the limited success of current treatments for DOX toxicity, there is a pressing need to explore alternative medical interventions, particularly from plant sources. This study was conducted to investigate the potential protective effect of ethanolic extract of Andrographis paniculata leaves (EEAP) against DOX-induced cardiac inflammation, liver toxicity, and anemia.Materials and methods: Sprague-Dawley rats were intraperitoneally injected with DOX at a total dose of 16 mg/kgBW. EEAP was administered orally for 4 weeks at doses of 125, 250, and 500 mg/kgBW/day according to the assigned treatment groups. The mRNA expression levels of interleukin-1β (IL-1β) and nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) in the heart tissue, along with the concentrations of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) and calcium level were examined. Additionally, the hematological parameters (including hematocrit, hemoglobin and red blood cells (RBCs)), aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and malondialdehyde (MDA) levels in blood were also analyzed.Results: EEAP dose-dependently decreased the mRNA expressions of IL-1β (p<0.05), tended to decrease mRNA expression of NLRP3 and the concentrations of NFκB and calcium in heart tissue compared with the DOX-only group. Additionally, EEAP dose-dependently decreased ALP values (p<0.0001) and tended to improve hematological parameters, as well as AST and MDA levels in serum.Conclusion: This extract may prevent DOX-induced cardiac inflammation, anemia, and hepatotoxicity. However, further studies are needed to confirm these findings, including the efficacy profile of the extract in cancer rats treated with DOX.Keywords: doxorubicin, Andrographis paniculata, inflammation, anemia, hepatotoxicity, herbal medicine
Co-Authors -, Paramita Achmad, Fariz Adam Iskandarmudasyah Adhayati, Baety Adisti Dwijayanti Agnes Frethernety Agus D. Susanto Ahmad Aulia Ali Sodikin Amanah Amanah Anang Endaryanto Andita Fitri Mutiara Rizki, Andita Fitri Mutiara Angelica Riadi Alim Saputro Angelina Riadi Alim Saputro Anom Bowo Laksono Antarianto, Radiana Dhewayani Anton Bahtiar Anton Bahtiar Ari Estuningtyas, Ari Aria Kekalih Arini Setiawati Arini Setiawati Arleni Arleni Aurelia Demtari Tuah Ayu Suraduhita Azmi, Wihda Aisarul Barasila, Atikah Chalida Budi Setiabudiawan Budi Wiweko Clara Riski Amanda Deni Rahmat Dewi, Yulia Ratna Didi Haryadi Didi Haryadi Dina Muktiarti, Dina Elisna Syahruddin Elly Yanah Arwanih Elvira Yunita Erlina Santoso Erni H. Purwaningsih Eziefule, Oluebube Magnificient Fajri, Purnama Fasha, Iqbal Franciscus D. Suyatna Frans D. Suyatna Gayatri, Anggi Gigih Andy Putra, Achmad Ginting, Tribowo T. Halim, Kelvin Handayani, Nur Hayati Dwi HANS-JOACHIM FREISLEBEN I MADE ARTIKA Indah D Dewijanti Johannes Hudyono Kato, Mitsuyasu Ketut Dewi Kumara Wati Khariri Khariri Layal, Kamalia Madoka Takeuchi Manggiasih Dwiayu Larasati Masahiro Takeuchi Mega Putri Utami Mila Maidarti Mizuno, Seiya Muhaimin Muhaimin Mulyadi Djer Nabillah, Deya Adiby Nafrialdi Nafrialdi Nasrun, Martina WS. Ni Made Dwi Sandhiutami Nihayah, Silviatun Nining Handayani Novi S. Hardiany Novita, Rachma Nur Hayati Dwi Handayani Pandelaki, Jacub Paramita - Paramita - Paramita, Paramita Pawitan, Jeanne Adiwinata Perdhana, Ika S. Puspita E. Wuyung Puspita Eka Wuyung Puspita Eka Wuyung Puteri, Meidi U. Putrihamidah, Diyanthie Aulia Rachma Novita Rachma Novita Rachman, Andika Raymond R. Tjandrawinata Rebecca Noerjani Angka Resda Akhra Syahrani Rianto Setiabudy Rianyta Rianyta Safitri, Yolanda Sake Juli Martina SEKAR ARUMSARI, SEKAR Septelia I. Wanandi Septelia Inawati Wanandi SEPTELIA INAWATI WANANDI Setiabudy, Rahajuningsih D Shafilla Yunilma Andriany Sianipar, Erlia Anggrainy Sianipar, Erlia Anggrainy Siregar, Josephine Elizabeth Siste, Kristiana Sri W.A. Jusman Sumadiono Sumadiono Suratih, Ni Made Desy Syahrani, Resda A. Syarifah Dewi Tarigan, Immanuel N. Tri Yuliani Trishna, Alya R. Ungke Antonjaya Utami, Diah S. Vivian Soetikno Vivian Soetikno Vivian Soetikno Wahyunia Likhayati Septiana Wardhani, Bantari W.K. Watanabe, Yukihide Watanabe, Yukihide Wawaimuli Arozal Wawaimuli Arozal Wawaimuli Arozal Yolanda Safitri Yolanda Safitri Zakiudin Munasir