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All Journal Research Journal of Life Science Indonesian Journal of Human Nutrition INDONESIAN JOURNAL OF PHARMACY NurseLine Journal Media Ilmu Kesehatan Journal of Dedicators Community Science Midwifery Majalah Kesehatan Indonesia Caring : Jurnal Pengabdian Masyarakat Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Asian Journal of Health Research Jurnal Ilmiah Kesehatan Mandala Waluya Jurnal Info Kesehatan
Nurdiana Nurdiana
Department Of Pharmacology, Faculty Of Medicine, Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Hubungan Keterampilan dengan Kesiapsiagan Perawat dalam Menghadapai Bencana Kabut Asap Nurdin; Nurdiana; Yati sri hayati
Jurnal Ilmiah Kesehatan Mandala Waluya Vol. 1 No. 1 (2021): Jurnal Ilmiah Kesehatan Mandala Waluya
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54883/jikmw.v1i1.634

Abstract

Hampir seluruh bagian negara di dunia pernah mengalami kebakaran hutan seperti Amerika Serikat, Australia, Yunani, Swaziland, termasuk Indonesia. Salah satu efek dari kebakaran hutan dan lahan yang terjadi di Indonesia dalah bencana kabut asap. Data BNPB pada tahun 2015 terkait dampak bencana kabut asap, terdapat 503.884 penderita ISPA yang tersebar diberbagai provinsi seperti Sumatra selatan, Riau, Jambi, Kalimantan selatan, tengah dan barat, serta menimbulkan korban jiwa sebanyak 26 orang. Selain itu, dampak kabut asap menimbulkan kerugian ekonomi sangat besar mencapai 200 triliun rupiah dan 43 juta penduduk terpapar kabut asap. Tujuan penelitian ini untuk menganalisis hubungan keterampilan dengan kesiapsiagaan perawat puskesmas dalam menghadapi bencana kabut asap di Kota Pontianak. Metode yang digunakan survei analitik dengan pendekatan cross sectional study dengan jumlah responden 90 perawat puskesmas secara simple random sampling. Pengukuran kesiapsiagaan perawat menggunakan kuesioner Emergency Preraredness Information Questionnaire. Hasil uji spearman ranks menjelaskan terdapat hubungan antara keterampilan dengan kesiapsiagaan perawat puskesmas dalam menghadapi bencana kabut asap di kota Pontianaknilai (p = 0.000) dimana nilai p < α, adapun dengan nilai r = 0.412, menjelaskan hasil interpretasi korelasi arah positif dengan makna kekuatan hubungan sedang. Keterampilan adalah faktor yang merupakan salah satu faktor yang penting dalam menghadapi bencana kabut asap di Kota Pontianak.
The Effect of Nanocurcumin Administration on Plasma Malondialdehyde (MDA) Levels in Pregnant Wistar Rats (Rattus norvegicus) as a Preeclampsia Model: Pengaruh Pemberian Nano Kurkumin terhadap Kadar Malondialdehyde (MDA) Plasma Darah Pada Tikus Wistar (Rattus norvegicus) Bunting Model Preeklampsia Subandi Subandi; Laras Indah Sari; Nurdiana Nurdiana
Majalah Kesehatan Indonesia Vol. 6 No. 1: 2025
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/makein.2025226

Abstract

Preeclampsia is a pregnancy complication associated with oxidative stress and increased levels of malondialdehyde (MDA), leading to endothelial dysfunction and impaired placental perfusion. Nanocurcumin possesses antioxidant properties that can mitigate oxidative stress; however, its effectiveness in reducing MDA levels in preeclampsia requires further investigation. This study aims to evaluate the effect of nanocurcumin administration on plasma MDA levels in pregnant Rattus norvegicus models of preeclampsia induced using Nw-Nitro-L-Arginine Methyl Ester (L-NAME). A total of 24 pregnant Wistar rats were divided into six groups: negative control (K-), positive control (K+), and four treatment groups receiving nanocurcumin at doses of 25 mg/KgBW (P1), 50 mg/KgBW (P2), 100 mg/KgBW (P3), and 200 mg/KgBW (P4). Preeclampsia was induced by administering L-NAME (125 mg/KgBW) for six consecutive days, followed by nanocurcumin treatment. Plasma MDA levels were measured using the Thiobarbituric Acid (TBA) assay and analyzed using the Kruskal-Wallis test and post-hoc Mann-Whitney test (p < 0.05). Nanocurcumin administration at 25 mg/KgBW and 50 mg/KgBW significantly reduced MDA levels compared to the preeclampsia group without treatment (p = 0.042, p < 0.05). However, a high dose of 200 mg/KgBW increased MDA levels, indicating a potential pro-oxidant effect. Low to moderate doses of nanocurcumin effectively reduced MDA levels in the preeclampsia model, but further studies are necessary to determine the optimal dosage and its safety in humans. Abstrak: Preeklamsia merupakan komplikasi kehamilan yang berhubungan dengan stres oksidatif dan peningkatan kadar malondialdehyde (MDA), yang menyebabkan disfungsi endotel dan gangguan perfusi plasenta. Nanokurkumin memiliki sifat antioksidan yang dapat mengurangi stres oksidatif, tetapi efektivitasnya dalam menurunkan kadar MDA pada preeklamsia masih perlu dikaji lebih lanjut. Penelitian ini bertujuan untuk mengevaluasi pengaruh pemberian nanokurkumin terhadap kadar MDA plasma pada tikus putih (Rattus norvegicus) bunting model preeklamsia yang diinduksi menggunakan Nw-Nitro-L-Arginine Methyl Ester (L-NAME). Sebanyak 24 ekor tikus Wistar bunting dibagi menjadi enam kelompok: kontrol negatif (K-), kontrol positif (K+), serta empat kelompok perlakuan yang menerima nanokurkumin dengan dosis 25 mg/KgBW (P1), 50 mg/KgBW (P2), 100 mg/KgBW (P3), dan 200 mg/KgBW (P4). Induksi preeklamsia dilakukan dengan pemberian L-NAME (125 mg/KgBW) selama enam hari, diikuti pemberian nanokurkumin. Kadar MDA plasma diukur menggunakan metode Thiobarbituric Acid (TBA) assay dan dianalisis dengan uji Kruskal-Wallis dan post-hoc Mann-Whitney (p < 0.05). Pemberian nanokurkumin 25 mg/KgBW dan 50 mg/KgBW secara signifikan menurunkan kadar MDA dibandingkan kelompok preeklamsia tanpa terapi (p = 0.042, p < 0.05). Namun, dosis tinggi (200 mg/KgBW) justru meningkatkan kadar MDA, menunjukkan efek pro-oksidan. Nanokurkumin dosis rendah hingga sedang efektif dalam menurunkan kadar MDA pada model preeklamsia, tetapi studi lanjutan diperlukan untuk menentukan dosis optimal dan keamanannya pada manusia.
Evaluation of Hematotoxicity in Female Wistar Rats Following Sub-Acute Inhalation Exposure to Polyethylene Microplastic Hikmawan Wahyu Sulistomo; Anisa Setyowati; Melani Chysti Situmorang; Ita Sulistiani; Dewi Azar Nuria Wardani; Kharisma Ciptaning Gusti; Nurdiana Nurdiana; Ihda Dian Kusuma; Bambang Rahardjo; Subandi Reksohusodo
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1585

Abstract

Polyethylene (PE) becomes a source of microplastics that can be widely distributed through the digestive and respiratory systems. However, its effects on blood cells are still being investigated. This study aims to analyze the impact of Polyethylene Microplastic (PE-MPs) exposure on the blood of female rats, including erythrocytes, leukocytes, and platelets. This study used female Wistar rats, which were divided into control and PE-MP groups. PE-MP was administered via whole-body inhalation at a concentration of 15 mg/m³ for 4 hours daily for 28 days. The absorption of plastic particles detected in the human bloodstream is likely to occur through mucosal contact (either through ingestion or inhalation). After the exposure period, the rats were euthanized to collect blood samples through the heart. A complete blood count was performed using an automatic hematology analyzer, and blood morphology was analyzed using thin blood smears. This study used the Mann-Whitney test. PE-MP exposure increased erythrocyte and platelet counts without a corresponding rise in leukocytes. Erythrocytes showed abnormal morphology (12.73% with ovalocytes and tear-shaped cells). Erythrocyte indices (MCV, MCH, MCHC) showed no significant differences. Platelet count rose by 1.7% (p-value= 0.017). Leukocyte and neutrophil counts were lower (0.84 and 0.94 times lower, respectively), while lymphocytes and monocytes were higher (1.03 and 1.61 times higher, respectively) in the PE-MP group compared to controls. The neutrophil-to-lymphocyte ratio did not differ significantly. PE-MP exposure in rats disrupts blood parameters, altering erythrocyte morphology and increasing platelet counts. Potential causes include oxidative stress, immune responses, and compensatory mechanisms. Study limitations include a small sample size and exclusive focus on inhalation exposure. Integrating multiple exposure routes (inhalation, ingestion, dermal) could offer a broader view of microplastic impacts. Future research with larger samples, diverse doses and durations, and exploration of additional markers or organ-specific effects is crucial for understanding PE-MP toxicity in real-world scenarios.               
Co-Authors Akbar Farid Hasibuan Anisa Setyowati Antonius Christianto Astri Proborini Bambang Rahardjo Budi Rahayu Choirinnisa Meilia Ayu Putri Darotin, Rida Dewi Azar Nuria Wardani Dian Hasanah Diana Lyrawati Elvira Sari Dewi fatchiyah . Handono Kalim Hani Susianti Hikmawan Wahyu Sulistomo Ihda Dian Kusuma Ita Sulistiani Kalsumy, Umi Keshya Venesa Kharisma Ciptaning Gusti Kusworini Handono Kusworini Handono Laras Indah Sari Lidwina Faraline Triprisila Melani Chysti Situmorang Nadia Magdalena Ni Luh Putu Herli Mastuti Nia Kurnianingsih Nora Ariyanti Nur Sophia Matin Nurdin Nurdin Nursari Abdul Syukur Olivia Anggraeny Perdana Aditya Rahman Pratama, Mirza Zaka Ra. Aminah Maya Rahmawati Nurul Fadilah Rahmawati Wahyuni Regina Ayu Fristiyanti Rista Nikmatu Rohmah Safrina Dewi Ratnaningrum Sanarto Santoso Siti Candra Windu Baktiyani Stefany Dame Stephani .Nesya Subandi Subandi Subandi Subandi Sylvia Winnie Tina Handayani Nasution Titin Andri Wihastuti Tri Wahyudi Iman Dantara Utami, Juliyatin Putri Wahono, Cesarius Singgih Wisnu Barlianto Yati Sri Hayati Yuni Sari Yuseva Sariati