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All Journal Jurnal Kedokteran Diponegoro The Indonesian Biomedical Journal Media Medika Muda Journal of Dedicators Community Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Ariosta Ariosta
Department Of Clinical Pathology, Faculty Of Medicine, Diponegoro University
Arts Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major Patients Widodo, Sabar; Widyastiti, Nyoman Suci; Limijadi, Edward Kurnia Setiawan; Hendrianingtyas, Meita; Retnoningrum, Dwi; Ariosta, Ariosta; Nency, Yetty Movieta
The Indonesian Biomedical Journal Vol 17, No 4 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i4.3706

Abstract

BACKGROUND: Thalassemia patients with repeated transfusions (multi-transfusion) are often at risk of experiencing early osteoporosis. Several studies have demonstrated that osteoporosis in these individuals was associated with altered bone remodeling, characterized by decreased insulin-like growth factor-1 (IGF-1) and serum calcium ions, as well as increased serum β-Cross Laps (β-CTx) levels. Despite the prevalence of this condition, there is limited literature on the relationship between IGF-1 levels and calcium ions with β-CTx. Therefore, this study was conducted to examine the relationship between IGF-1 and calcium ions levels with serum β-CTx in multi-transfused β-thalassemia major patients.METHODS: A cross sectional study involved 29 thalassemia patients with multiple transfusions, aged 2-18 years, that were selected from the electronic medical records. Calcium ion levels were examined using ion selective electrode method. Subsequently, IGF-1 and serum β-CTx levels were examined by enzyme-linked immunosorbent assay (ELISA), and the data were analyzed using the Pearson correlation test.RESULTS: The results showed that the mean serum IGF-1 levels, calcium ion, and β-CTx were 20.11±20.763 ng/mL, 1.26±0.07 mmol/L, and 9330.40±1696.76 ng/mL, respectively. Statistical analysis showed a significant relationship between the levels of IGF-1 (r=-0.573; p=0.001) and calcium ion (r=-0.373; p=0.046) with serum β-CTx. A moderate negative relationship was found between IGF-1 levels and β-CTx, while calcium ion levels and β-CTx showed a weak negative relationship.CONCLUSION: A moderate negative correlation between IGF-1 and serum β-CTx, and a weak negative correlation between calcium ion and serum β-CTx suggest that IGF-1 and calcium ions may serve as potential indicators of bone turnover and osteoporosis risk in multi-transfused β-thalassemia major patients, underscoring their potential role in routine clinical evaluations.KEYWORDS: miR-200a expression, NO level, early-onset preeclampsia, late-onset preeclampsia
Co-Authors Afriana, Rizky Dyas Agung Satria Winahyu Andreas Arie Setiawan Andreas Arie Setiawan Andreas Arie Setiawan, Andreas Arie Aryu Candra Blasius Adrian Budianto Charles Limantoro Charles Limantoro Darmawati Ayu Indraswari Dhega Anindita Wibowo Dhika Adhi Pratama Diah Ajeng Purbaningrum Djuara P Lubis Dwi Retnoningrum Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Eka Yudhanto Elsa Naviati Gabriella Carolina Hutapea Gloria Permata Usodo Grace Yuni Harviendo Hanny Tiara A Sinaga Hardian Hardian Herniah Asti Wulanjani Ilham Uddin Imam Budiwiyono Indra Adhim Karunia Aji Indranilla K. Samsuria Jessica Christanti Josevaldo Bagus P Kaninta Nuga Sekunda Mega Femina Qurrati Meita Hendrianingtyas Muniroh, Muflihatul Muyassar, Abyan Mursyid Nina Dorothea Budiamal Nyoman Suci Widyastiti Partiwi, Rina Paulus Rio Kurniawan Retnoningrum, Dwi Salma S Salma S Sefri Noventi Sofia Setyo Gundi Pramudo Utami, Sulistiyati Bayu Vonny Folanda Widjaja, Daniel Karen Widodo, Sabar Yanuarius Alvin Pratama Budianto Yetty Movieta Nency Yetty Movieta Nency, Yetty Movieta Yosef Purwoko