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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin

Sawitri Sawitri

Departemen / Staf Medik Fungsional Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya

Author-ID : 3287384

Immunology & microbiology Public Health

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Scabies in Children: A Retrospective Study Retha Retha; Sawitri Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.55-61

Background: Scabies is a skin disease in humans and is caused by Sarcoptes scabiei mite. It burrows into the skin and is transmitted through close physical contact. The common symptom is itchiness, mainly occur at night, along with a history of itch from family members or friends with whom the patients might have close physical contact before. Scabies is still a concerning health problem for the majority of poor and developing countries. Purpose: To evaluate the profile of newly-admitted children scabies patients. Methods: This study retrospectively evaluated the medical records of subjects with scabies in the Children Dermatology Division, Dermatology and Venereology Department of Dr. Soetomo General Academic Hospital, Surabaya, between January 2012 and December 2014. Results: There were 545 patients with scabies (33.6% from Children Dermatology Division visit and 3.2% from overall outpatient clinic visit), mainly consisted of children aged 5-14 years old (69%), and mostly males (62.6%). The most common symptom was itchiness (70.28%), most patient sought treatment after the complaint have been persisted for more than 30 days (51.7%), and 66.4% patients have family members with similar complaint. Most of the lesions were found on the hands (60.37%), mostly as papules (73.2%). Almost all of them did not undergo a skin scraping examination (99.1%). The most common therapy combination was permethrin 5% and oral antihistamine (49.7%). Conclusions: This profile on scabies patients was expected to aid in improving scabies treatment in the future.

The Concordance of Three Diagnostic Test for Malassezia folliculitis using Potassium Hydroxide 20% + Blue-Black Parker Ink, May Grunwald Giemsa, and Potassium Hydroxide 10% + Chicago Sky Blue Dyatiara Devy Rahadiyanti; Evy Ervianti; Damayanti Damayanti; Dwi Murtiastutik; Sawitri Sawitri; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.33-39

Background: Malassezia folliculitis is a pilosebaceous follicular infection disease caused by Malassezia species. There are many misdiagnosed Malassezia folliculitis cases, causing the maladministration of therapy. A routine diagnostic test performed for Malassezia folliculitis cases is the identification of fungal elements (spore) with a microscope using potassium hydroxide, but it has several weaknesses. Purpose: To evaluate the suitability of Malassezia folliculitis diagnostic test using Potassium Hydroxide 20% + Blue-Black Parker Ink, May Grunwald Giemsa, and Potassium Hydroxide 10% + Chicago Sky Blue. Methods: Analytic observational study conducted in the Dermatomycology Division of Dermatology and Venereology outpatient clinic, Dr. Soetomo General Hospital Surabaya. The samples were thirty patients with clinical features of Malassezia folliculitis. The research material was obtained from the body as many as three pieces of papulomoluscoid lesion extracted. The material obtained was then divided into three glass objects for Potassium Hydroxide 20% + Blue-Black Parker Ink, May Grunwald Giemsa, and Potassium Hydroxide 10% + Chicago Sky Blue staining. Result: The identification of spores using Potassium Hydroxide 20% + Blue-Black Parker Ink was 90%, May Grunwald Giemsa was 90%, and Potassium Hydroxide 10% + Chicago Sky Blue was 93% with a value of κ=0.348 and p=0.051. The diagnostic values of May Grunwald Giemsa and Potassium Hydroxide 10% + Chicago Sky Blue were 96.6% sensitivity, 33.3% specificity, 92.9% Positive Predictive Value, and 50 % Negative Predictive Value. Conclusions: There was no significant concordance between May Grunwald Giemsa and Potassium Hydroxide 10% + Chicago Sky Blue with Potassium Hydroxide 20% + Blue-Black Parker Ink in establishing the diagnosis of Malassezia folliculitis. Potassium Hydroxide 20% + Blue-Black Parker Ink is still needed as a routine examination in cases with clinical features of Malassezia folliculitis.

Long - Term Effects of Topical Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Fractional CO2 Laser in Photoaging Dyah Ayu Pitasari; Afif Nurul Hidayati; Muhammad Yulianto Listiawan; Sawitri Sawitri; Damayanti Damayanti; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.27-32

Background: Photoaging causes wrinkles, lentigines, keratoses, dyspigmentation, telangiectasia, decreased elasticity, rough texture, and pale color. Facial wrinkles and mottled skin can negatively affect perceived attractiveness, self-esteem, personality, and level of acceptance. Stem cells are important cells in the skin, and they are the source for continuous regeneration of the epidermis. It can be extracted from many sources, including amnion. Amnion membrane stem cell (AMSC) can be cultured and secretes metabolite product, and it can rejuvenate aging skin. Laser-Assisted Drug Delivery (LADD) involves selective destruction of the layers of the epidermis and dermis to allow penetration and absorption of topical drugs as well as large molecular weight drugs such as stem cells. Purpose: To evaluate the long-term effects of topical administration of AMSC metabolite products (AMSC -MP) and fractional CO2 laser on the clinical improvement of photoaging compared to previous skin conditions. Methods: This was an observational study which was aimed to evaluate the long-term effects of clinical improvement after topical therapy of AMSC-MP and fractional CO2 laser in patients with photoaging. Results: The results of the analysis showed a decrease in wrinkles, dark spots, skin tone, and pores. Conclusion: Based on Janus-II® assessment, there was improvement degrees of wrinkles, dark spots, and pores in patients with photoaging who received fractional CO2laser fractional for 12 weeks. There were no side effects found in this study.

Retrospective Study of Self Esteem in Patients with Pityriasis Versicolor Bagus Meurah Suropati; Eko Budi Koendhori; Sawitri Sawitri; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 2 (2020): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.2.2020.93-97

Background: Pityriasis Versicolor (PV) is a fungal infection of the skin, caused by the Malassezia sp., a genus of fungi. Patients commonly present with bordered skin patches of white, grey, and sometimes brown on their skin surface. The prominent changing of skin colour in exposed areas of the skin may cause feelings of insecurity to the patients and become limelight for other people, impacting their self esteem. Purpose: To evaluate the self esteem profile in PV patients at the dermatovenereology outpatient clinic of Dr. Soetomo General Academic Teaching Hospital Surabaya. Methods: This was a retrospective descriptive study based on medical records of the dermatovenereology outpatient clinic of Dr. Soetomo General Academic Teaching Hospital Surabaya. The data were collected from June 2018 to May 2019. This research evaluates PV patients's profiles by age, sex, education level, occupation, residential environment, site of infection, duration of the infection, and self esteem. The patient's self esteem was assessed using the Rosenberg Self Esteem Scale (RSES). Result: Fiftythree PV patient’s self esteem values were successfully recorded. Of the 53 patients, the score was low in 3 people (5.67%), the normal score in 50 people (94.33%), and no one had a high score. Of the 3 people with low self esteem scores, 2 of them were men, consisting of 1 teenager and 2 adults, having basic education levels, who were students and housewives. The three patients had the infection for more than 3 months and they resided in Tambaksari, Wonocolo, and outside Surabaya. Conclusion: The majority of PV patients at the dermato-venereology outpatient clinic of Dr. Soetomo General Academic Teaching Hospital have normal self esteem scores.

Malignant Melanoma in Child with Xeroderma Pigmentosum: A Rare Case Riezky Januar Pramitha; Sawitri Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.70-74

Background: Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder characterized by photosensitivity, cutaneous pigmentary changes, and malignant tumor development at an early age. The basic defect underlying the clinical manifestations is nucleotide excision repair defect, leading to defective repair of ultraviolet (UV)-induced DNA. XP patients who are younger than 20 years of age have more than 1000-fold increased risk of developing malignant neoplasms of the skin, which commonly include squamous cell carcinoma, basal cell carcinoma, fibrosarcoma, and malignant melanoma. Malignant melanoma arises in only about 3% of XP patients. Purpose: To report a case of malignant melanoma in a child with XP. Case: A 7-years-old girl presented with multiple hypopigmentation and hyperpigmentation macules since age of two, throughout the body, more on sun-exposed areas. The physical examination showed solitary tumor extensive ulcero- proliferative surface with areas of hemorrhage and blackish pigmentation on the vertex region. Histological examination revealed a feature of nodular malignant melanoma, and the condition became worse after she underwent two cycles of chemotherapy. Discussion: Despite the rare occurrence, the nodular type of malignant melanoma in XP patients is the most aggressive and responsible for the fatal condition. Conclusion: Early detection of XP is necessary due to its fast-growing nature and high metastatic possibility as well as mortality index.

The Efficacy of Topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging Agatha Anindhita Ardhaninggar; Dwi Murtiastutik; Sawitri Sawitri; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 2 (2020): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.2.2020.126-133

Background: Photoaging, also called extrinsic aging, is a premature skin aging mainly resulting from prolonged and extended exposure to ultraviolet (UV) radiation. Amniotic Membrane Stem Cell Metabolite Products (AMSC-MP) are derived from amniotic membranes that contain cytokines and growth factors that have a role in the skin rejuvenation process. Vitamin E is an antioxidant that has a photoprotective effect, so it is expected to reduce the appearance of clinical signs of photoaging. Not only having skin rejuvenation effect, but microneedling is also expected to facilitate the penetration to increase the efficacy of AMSC-MP and vitamin E. This combination is expected to have a better effect on clinical photoaging improvement. Purpose: To evaluate the effect of a topical combination of AMSC-MP and vitamin E after microneedling on the clinical improvement of photoaging compared to previous skin conditions. Methods: Thirty adult women with photoaging topically administered a combination of AMSC-MP and vitamin E after 3 microneedling sessions at 2 weeks intervals. The evaluation of the improvement of the degree of pores, wrinkles, skin tone and dark spots were performed with the Janus-II Facial Skin Scope System. Result: There was a clinical improvement with a statistically significant difference in terms of the degree of pores, wrinkles, polarized black spots, and UV black spots, which were statistically significant differences (p <0.05). Conclusion: The administration of a topical combination of AMSC-MP and vitamin E after microneedling provided clinical improvement in photoaging as supported by the results of Janus analysis of pores, wrinkles, skin tones, polarized black spots, and UV black spots.

Topical Epigallocatechin Gallate (EGCG) 1% for Chronic Plantar Ulcers in Leprosy Riyana Noor Oktaviyanti; Cita Rosita Sigit Prakoeswa; Diah Mira Indramaya; Esti Hendradi; Sawitri Sawitri; Linda Astari; Damayanti Damayanti; Muhammad Yulianto Listiawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 2 (2020): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.2.2020.134-140

Background: Chronic plantar ulcers in leprosy (CPUL) increase morbidity, increase medical costs, cause loss of productivity, and decrease quality of life. CPUL is a severe complication of leprosy disease with a 10-20% incidence. In general, CPUL consume a significant amount of time to heal. Green tea extract contains high amount of Epigallocatechin gallate (EGCG). EGCG functions as antiinflammatory, antimicrobial, and immunomodulator. This suggests that EGCG is effective for dermal wound treatment by facilitating reepithelialization. Purpose: To investigate the effect of topical EGCG 1% on the CPUL healing process. Methods: The topical EGCG 1% were applied every three days for eight weeks. Size of the ulcers, side effects and possible complications were monitored weekly. Result: There were significant clinical and statistical differences in the size and depth of the ulcers (p=0.000), as observed in the EGCG group. There was no side effect and complication found. Conclusions: Topical EGCG 1% was effective for CPUL healing. Sixty three point six percent of the ulcers were clinically healed, 31.8% demonstrated improvement, and 4.6% no effect was observed.

Clinical Manifestation and Management of Terrestrial Animal Bites Emma Hidayati Sasmito; Sawitri Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 2 (2021): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.2.2021.135-140

Background: Terrestrial animal bites wounds are injuries caused by terrestrial animals' mouths and teeth. Aerobic and nonaerobic bacteria cause 30–60% of the secondary bacterial infections due to animal bites. Rabies is an infectious disease and it is the most dangerous viral infection caused by animal bites. Also, venomous animal bites can be fatal and cause death if not treated well. Purpose: To identify the clinical manifestation, first aid, and management of terrestrial animal bites to reduce morbidity and mortality. Review: Wounds and crush injuries caused by animal bites are prone to infection. Aerobic bacteria, such as Pasteurella multocida, Staphylococcus spp. (including methicillin–resistant Staphylococcus aureus (MRSA)), Capnocytophaga canimorsus, and Bartonella henselae, and anaerobic bacteria, such as Porphyromonas spp. are commonly found pathogens in animal bite wounds. Rabies, the most dangerous viral infection, occurs in wounds infected by the rabies virus. The virus enters the nerve tissue, multiplies, and spreads to the central nervous system. This can cause disability, and it is life-threatening. In snakebites, management of basic life support, transportation to the hospital, clinical assessment, and immediate resuscitation are the most important procedures. Conclusion: Animal bite wounds are injuries caused by animals' mouths and teeth. Dogs, cats, and snakes are terrestrial animals that most likely attack humans. Proper diagnosis, first aid, and comprehensive management are needed to reduce morbidity and mortality.

Combination of Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E for Photoaging Retha Retha; Sawitri Sawitri; Rahmadewi Rahmadewi; Afif Nurul Hidayati; Muhammad Yulianto Listiawan; Evy Ervianti; Linda Astari; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.1-6

Background: It is hypothesized that combination of amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO2 laser as laser assisted drug delivery (LADD) provides better long-term effects on clinical improvement of photoaging. This is promising as an option for photoaging therapy in the future. Purpose: The study aimed to evaluate long-term effects of improving the degree of wrinkles, polarized black spots, ultraviolet (UV) black spots, pores, and skin tones in subjects who have received a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD. Methods: Thirty adult women with photoaging who had been treated with topical AMSC-MP mixed therapy with vitamin E and CO2 fractional laser three times, were then given maintenance therapy, tretinoin cream 0.025% and sunscreen SPF 30. Observation of improvement of wrinkles, polarized black spots, UV black spots, pores, and skin tones were performed computer-stimulated photographs, Janus-II Facial Skin Scope System, three times every month for three months after the last treatment. Results: The evaluation of wrinkles, polarized black spots, UV dark spots, pores and skin tones from the assessment for three months after being receiving treatment of a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD on photoaging obtained p>0.05. Conclusion: There was a long-term effect of the topical mixture of AMSC-MP with vitamin C and CO2 fractional laser on photoaging, and there was no side effect observed.

The Effectiveness of 5% Tea Tree Oil cream, 10% Tea Tree Oil cream, and 5% Permethrin Cream for Scabies Treatment in Pediatric Patients Chesia Christiani Liuwan; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Evy Ervianti; Sawitri Sawitri; Cita Rosita Sigit Prakoeswa; Linda Astari; Farhat Surya Ningrat; Kurniati Kurniati; Endang Wahyu Fitriani; Irmadita Citrashanty; Regitta Indira Agusni; Iskandar Zulkarnain
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.200-205

Background: Scabies, an infectious disease caused by Sarcoptes scabiei mites, is still one of the most common skin diseases found in developing countries, including Indonesia. The 5% permethrin cream for scabies treatment has been investigated as having 2–3 time to cure scabies. Tea Tree Oil (TTO) is one of the agents that has been proven to have acaricidal potential as an anti-inflammatory, antibacterial, and antipruritic agent. It has minimal side effects in topical use. Purpose: To evaluate the effectiveness of 5% TTO cream and 10% TTO cream in scabies treatment of pediatric patients. Methods: This was an experimental, analytical study with controlled clinical trial methods, and a double-blind, parallel design comparing 5% TTO cream (treatment 1), 10% TTO cream (treatment 2), with 5% permethrin cream (control) to children with scabies. Result: The 5% TTO cream gave a cure rate of 61.5% and was significantly different from the 5% permethrin cream groups with a p-value = 0.044 in the first week of the study. The 5% permethrin cream gave a cure rate of 15.4%, and the cure rate of 10% TTO cream was 53.8% in the first week of the study. Conclusion: There was a significant difference between the 5% TTO cream and 5% permethrin cream in the first week of the study. The highest and fastest cure rates were found in the 5% TTO cream treatment group.

Co-Authors Afif Nurul Hidayati Agatha Anindhita Ardhaninggar Alpha Fardah Athiyyah Amalia Rositawati Amanda Gracia Manuputty Ardhiah Iswanda Putri Asmahani Thohiroh Bagus Meurah Suropati Chesia Christiani Liuwan Cita Rosita Sigit Prakoeswa Cita Rosita SP Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Desiana Widityaning Sari Diah Mira Indramaya Dwi Murtiastutik Dyah Ayu Pitasari Dyatiara Devy Rahadiyanti Eko Budi Koendhori, Eko Budi Emma Hidayati Sasmito Endang Wahyu Fitriani Esti Hendradi Evy Ervianti Farhat Surya Ningrat Frea Astrilia Tamarina Hari Sukanto, Hari Icha Aisyah Ingrid Suryanti Suryono Irmadita Citrashanty Iskandar Zulkarnain Kurniati Kurniati Linda Astari, Linda M. Yulianto Listiawan Maya Wardiana Nurina Dhani Rahmayanti Pepy Dwi Endraswari, Pepy Dwi Rahmadewi Rahmadewi Regitta Indira Agusni Renata Prameswari Retha Retha Ridha Ramadina Widiatma Riezky Januar Pramitha Riyana Noor Oktaviyanti Shinta Dewi Rahmadhani Shinta Dewi Rahmadhani Wahyunita Desi Ratnaningtyas Willy Sandika Yuri Widia, Yuri

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