Article Per Year (5 Year)
p-Index From 2020 - 2025
2.012
P-Index
This Author published in this journals
All Journal Journal of Tropical Biodiversity and Biotechnology Jurnal Dinamika Pengabdian (JDP) Indonesia Chimica Acta Indonesian Journal of Chemistry Communications in Science and Technology SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Chemistry Indonesian Journal of Chemical Research Jurnal Pengabdian Masyarakat Borneo Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Indobiosains Molekul: Jurnal Ilmiah Kimia
Hasnah Natsir
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Jl. Perintis Kemerdekaan Km 10 Tamalanrea, Makassar 90245, South Sulawesi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Chemistry Indonesian Journal of Chemical Research

 1 
Produksi Oligomer Kitosan dari Limbah Udang Windu (Panaeus monodon) Menggunakan Enzim Kitosanase dari Isolat Bakteri Klebsiella sp. Sarni, Sarni; Natsir, Hasnah; Dali, Seniwati
Indonesian Journal of Chemical Research Vol 3 No 2 (2016): Edisi Bulan Januari (Edition For January)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2016.3-sar

Abstract

Chitosan is a biopolymer that is the main content of D-glucosamine and several parts of N-acetyl-D-glucosamine bound to β- (1-4) glucoside. Chitosan receive special attention as functional biopolymers for applications in various fields. Chitosan is more effectively absorbed into the human body when it gets converted into chitosan oligomer form. Chitosan oligomer is a mixture of oligomers of D-glucosamine are formed through a process of severing ties depolymerization of chitosan with β-glycosidic. This study aims to produce chitosan oligomer of waste tiger shrimp (Penaeus monodon) using enzyme kitosanase of bacteria Klebsiella sp. Chitosan oligomer produced by using the enzyme chitosanase at a temperature of 40 °C and pH 8 with the activity of 0.309 U/mL (5,235 U/mg) obtained in the form of a mixture of monomer to octamer, which soluble in acetic acid 0.25% to 0.5%, having intrinsic viscosity decreases with increasing time of incubation is 0.195 (1 hour incubation); 0.9 (incubation 2 hours) and 0.7 (incubation 3 hours) with molecular weight range of 4103.12 g/mol (incubation 1 hour) ; 1483.48 g/mol (incubation 2 hours) and 1065.79 g/mol (incubation 3 hours).
In Vitro and In Silico Assessment of Methanol Extract from Moringa oleifera Seeds as α-Amylase Inhibitor Natsir, Hasnah; A Arfah, Rugaiyah; Arif, Abdur Rahman; Nadir, Muhammad; Anita, Anita; Sartika, Sartika; Rahmi, Nur; Karimah, Aulia
Indonesian Journal of Chemical Research Vol 12 No 2 (2024): Edition for September 2024
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2024.12-has

Abstract

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, posing a global health threat. Current diabetes treatments often rely on synthetic drugs with side effects, prompting the search for safer natural alternatives. This study investigated the secondary metabolic compounds in methanol extract from M. oleifera seeds and evaluated their antidiabetic activity. The α-amylase enzyme was analyzed to determine optimal incubation time, pH, and temperature. The antidiabetic activity was assessed via α-amylase inhibition using in vitro and in silico methods. Phytochemical screening revealed the presence of flavonoids, alkaloids, and tannins in the extract. Optimal enzyme conditions were 30 minutes of incubation, pH 6.9, and 25 °C. The extract showed the highest activity at 15% concentration with 67.94% inhibition and an IC50 of 15.38%, compared to acarbose with 41.76% inhibition and an IC50 of 17.89%. In silico analysis indicated that 9-octadecanoic acid (Z) methyl ester had a lower inhibition constant and binding energy (2.67 mM and -3.51 kcal/mol) than acarbose (15.72 mM and -2.46 kcal/mol), suggesting a higher enzyme affinity. These findings suggest that M. oleifera seeds contain compounds with potential as antidiabetic agents.
Co-Authors A Arfah, Rugaiyah Abdul Karim Abdur Rahman Arif, Abdur Rahman Ahyar Ahmad Alam, Muh. Nur Ali Muhakim Andi Evi Erviani Anggriani, Dhea Faraditha Anita Anita Arfah, Rugaiyah Arfah, Rugaiyah A Arfah, Rugaiyah A. Aziz, Fitria Chatarina Umbul Wahyuni Djabal Nur Basir dwyana, Zarsawaty Fauziah, St Gita, Gita Harningsih Karim Indah Raya Irfandi, Rizal Karimah, Aulia Khairunnur, Siti Mardianti, Riska Mardiyanti, Riska Maswati Baharuddin Muh. Yusri Karim Muhammad Nadir Muhammad Zakir Munandar, Nurharis Musa, Bulkis Nur Asmi Nur Haedar Paulina Taba Permatasari, Nur Umriani Prastawa Budi Ramadani, Ananda Rasyid, Herlina Rauf, Wahyudin Riskawati Riskawati, Riskawati Sarlan, Sarlan Sarni Sarni Sartika Sartika Seniwati Dali SITI HALIMAH LAREKENG, SITI HALIMAH Situmorang, Sarah Victoria Octovianni Solly Aryza St Fauziah, St Fauziah Sukmawaty, Eka Suriati Eka Putri Syaharuddin Kasim Yunita, Vivi Alfi Yusafir Hala