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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Acta Biochimica Indonesiana Bioscientia Medicina : Journal of Biomedicine and Translational Research Eureka Herba Indonesia Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research
Lusia Hayati
Department Of Biology, Faculty Of Medicine, Sriwijaya University, Palembang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Eureka Herba Indonesia

 1 
The Effects of Sambiloto Leaf Extract (Andrographis paniculata) on Blood Sugar Regulation: An In Vivo Study Rachmat Hidayat; Lusia Hayati
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.1

Abstract

Sambiloto (Andrographis paniculata) is one of the most common plants in Indonesia. Sambiloto contains quite varied secondary metabolites, where this plant is rich in flavonoids, alkaloids, terpenes and glycosides. This study aims to assess the effect of Sambiloto (Andrographis paniculata) leaf extract on blood sugar levels and the expression of GLUT4 protein in muscle tissue which indicates the potential of the test extract's ability to improve blood glucose intake to cells so that it can maintain blood sugar regulation. The process of extracting sambiloto is carried out by maceration in which 500 grams of simplicia are macerated with 96% ethanol for 72 hours. After 1 week of adaptation, the mice were randomly divided into the following six groups, each containing 5 animals: Normal control group, diabetes group (negative control), diabetes + metformin group (Met; 45 mg/kg), Diabetes + ES group (50 mg/kg), diabetes + ES group (100 mg/kg) and diabetes + ES group (200 mg/kg). The treatment with sambiloto extract was able to reduce blood sugar levels significantly, were at the ES 100 and 200 mg/kg BW doses it was able to reduce blood sugar levels to reach the target below 200 mg/kg BW. The dominant flavonoids in Sambiloto leaf extract are believed to be responsible for the effect of blood glucose regulation. In conclusion, Sambiloto extract affects lowering blood sugar levels in diabetes mellitus white rats by increasing glucose intake in cells and tissues.
Effect of Bay Leaf Extract (Syzygium polyanthum) on Blood Sugar Regulation via GLUT4 Protein Regulation in Rat Muscle Tissue Induced Aloxan Lusia Hayati; Rachmat Hidayat
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.4

Abstract

Diabetes mellitus is a chronic condition that disturbs the body's blood sugar regulation. Bay leaves contain entirely various secondary metabolites, and this plant is rich in flavonoids, alkaloids, terpenes, and glycosides. This study aims to assess the effect of bay leaf extract (Syzygium polyanthum) on blood sugar levels and the expression of GLUT4 protein in muscle tissue. A total of 30 white rats (Rattus norvegicus) Wistar strains were obtained from the Eureka Research Laboratory (Palembang, Indonesia) weighing between 200 – and 250 grams. Bay leaf Simplicia was obtained from the Tawangmangu Herbal Research Center, Karanganyar, Indonesia. After 1 week of adaptation, the mice were randomly divided into the following six groups, each containing 5 animals: Normal control group, diabetes group (negative control), diabetes + metformin group (Met; 45 mg / kg), Diabetes + BLE (75 mg/kg), diabetes + BLE group (150 mg / kg) and diabetes + BLE group (300 mg/kg). Alloxan-induced white rats showed a very significant increase in blood sugar levels, where the use of the drug metformin was able to reduce blood sugar levels significantly even though they had not reached the target blood glucose target of less than 200 mg / dL. The treatment with bay leaf extract was able to reduce blood sugar levels significantly. The administration of metformin drugs or bay leaf extract showed the ability to increase the level of GLUT4 protein. In conclusion, bay leaf extract affects reducing blood sugar levels in diabetes mellitus white rats by increasing glucose intake in cells and tissues.
The Effect of Bay Leaf Extract (Syzygium polianthum) Against Cholesterol Regulation in Hypercholesterolemic Rats Lusia Hayati; Rachmat Hidayat
Eureka Herba Indonesia Vol. 1 No. 2 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i2.6

Abstract

Cholesterol is an important precursor that plays a role in the production and regulation of various sterol group compounds, especially steroid hormone compounds, androgen hormone compounds, cortisol compounds, and estrogen compounds. This herb is known to have the effect of improving glucose regulation by increasing glucose intake into cells and tissues. Its ability to improve cell and tissue metabolism is mediated by the content of secondary metabolite compounds. This ability is believed to have the potential to improve cholesterol regulation. Bay leaf extract is effective in lowering cholesterol levels through regulation of Acetyl CoA production.
Indonesian Plants with Potential as Anti-diabetes Mellitus Agent Rachmat Hidayat; Lusia Hayati; Nita Parisa
Eureka Herba Indonesia Vol. 1 No. 2 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i2.7

Abstract

Diabetes Mellitus (DM) is a degenerative disease that continues to increase in number in Indonesia and is a disease that is spread throughout the world due to unbalanced nutritional conditions. Treatment of diabetes mellitus is a chronic and lifelong treatment. Treatment of diabetes mellitus, such as the use of insulin and oral antihyperglycemia drugs, is relatively expensive, is used for a long time and can cause unwanted side effects. There are many plants that have potential as antihyperglycemia drugs. One of the active compounds that act as antihyperglycemia is flavonoids.Flavonoids derived from various types of plants studied are thought to act as antihyperglycemic agents. Flavonoids are known to have the ability to scavenge free radicals or act as natural antioxidants. The antioxidant activity of flavonoids is related to phenolic –OH groups which can capture or neutralize free radicals (such as ROS or RNS). Flavonoids can play a role in pancreatic tissue damage caused by DNA alkylation due to alloxan induction as a result of improving the morphology of the rat pancreas.
Co-Authors Akhyar Dyni Zakyah Arwan Bin Laeto Beauty Novianty Ella Amalia, Ella Joko Marwoto Masayu Farah Diba Mastiar Endang Frida Siahaan Nita Parisa Oktariana, Desi Phey Liana RACHMAT HIDAYAT Rara Inggarsih Septi Purnamasari Siska Delvia Vena Sabputri Sutrisno Yuwono Ziske Maritska