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Journal : Jurnal Insan Farmasi Indonesia

UJI AKTIVITAS ANTIKOLESTEROL HASIL FERMENTASI ANGKAK PADA TIKUS GALUR Sprague dawley Abdul Rahman Wahid; Armiyatin Damayanti; Alvi Kusuma Wardani
Jurnal Insan Farmasi Indonesia Vol 2 No 2 (2019)
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v2i2.296

Abstract

Hypercholesterolemia is a condition in which the levels of cholesterol in the blood increases and decreases in HDL cholesterol levels below the normal range. Low levels of HDL cholesterol and high levels of LDL cholesterol can increase the risk of atherosclerosis. Angkak is a fermented product from brown rice using mold Monascus purpureus. Angkak contains secondary lovastatin which functions as an anti-cholesterol. This study aims to determine the effect of the administration of brown rice Angkak to decreasing LDL levels at a dose of 15 mg/200gBB, 40 mg/200gBB, and 65 mg/200gBB in mice induced by high cholesterol feed. This type of research is true experimental laboratory withmethods pre and post test control group design. The results showed that Angkak dosages of 15 mg / 200gBB, 40 mg / 200gBB, and 65 mg / 200gBB were able to reduce levels in rats induced high cholesterol. The conclusion of this study is that red rice Angkak containing lovastatin has an anticolesterol effect on decreasing total cholesterol, LDL, and trigliseride levels in rats.
DAYA HAMBAT BAKTERI Staphylococcus aureus EKSTRAK DAUN GAHARU (Aquilaria malea L.) SEBAGAI ANTIBAKTERI Abdul Rahman Wahid; Dzun Haryadi Ittiqo
Jurnal Insan Farmasi Indonesia Vol 2 No 1 (2019)
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

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Abstract

Aquilaria malea L. are spread naturally in several countries, one of them in Indonesia. This plant has many benefits ranging from stems and leaves. Agarwood leaves contain various antibacterial compounds such as flavonoids, alkaloids, saponins and tannins. Staphylococcus aureus is a facultative anaerobic gram-positive bacterium which is the cause of infection in wounds in the form of abscesses or a collection of pus. The study aims to determine the inhibitory strength of Staphylococcus aureus bacteria extract of aloes leaves as anti-bacterial. This type of research is laboratory experimental through the disc diffusion method. The concentration of agarwood leaves used is 300, 350, 400, and 450 mg/ml and positive control Amoxicillin. Data were analyzed using One Way Annova. The results of this study showed the average inhibition zone of agarwood leaf extract against Staphylococcus aureus bacteria with agarwood leaf extract concentration of 300 mg/ml (15.33 ± 2.51), concentration of 350 mg/ml (16.33±2.25), concentration of 400 mg/ml (20.5± 2.17), concentration of 450 mg/ml (21.17±3.32) and inhibition zone of Amoxicillin (37±0.00). This concluded that agarwood leaf extract had inhibitory potential for the growth of Staphylocccus aureus bacteria. The biggest inhibition power of Staphyloccus aureus growth was 450 mg/ml (21.17 ± 3.32).