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Journal : Bioscientia Medicina : Journal of Biomedicine and Translational Research

The Efficacy of Temu Putih Fraction (Curcuma Zedoaria (Berg) Roscoe) Related Quality and Quantity of Spermatozoa in Male Wistar Rats Tiara Fatrin; Salni Salni; Sri Nita; Rachmat Hidayat; Triwani Triwani; Joko Marwoto; Ziske Maritska; Mgs Irsan Saleh; Nita Parisa; Nia savitri Tamzil; Evi Lusiana; Ayeshah Agusta Rosdah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 1 No. 1 (2017): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v1i1.12

Abstract

Background Male participation in KB is still relatively low when compared to the participationof women. Researchers have to do research to find the contraception drug. Temu putih (Curcuma Zedoaria (Berg) Roscoe) is one of traditional herb that used as antifertility. Aim of Study Aim of this study to examine change in the amount, motility, morphology, and viability spermatozoa male rats (rattus norvegicus) due to temu putih fraction suplementation. Methods This study was an experimental study using a completely randomized design (CRD), post test with control group design. The sample in this study was 30 male rats, 10 weeks old, weight 150-200 gram. Rats were given temu putih fraction (n hexan, etylacetate and methanol-water) at dose of 300 mg/kgBB/day for 48 days. Temu putih was extracted by ethanol and did fractionation by liquid-liquid methods. The results of this study were assayed by SPSS 18. Results The amount, motility, morphology and viability of spermatozoa in the group of metanol fraction of water decreased compared with the control group (p= 0,000), motilitas of spermatozoa in the group of metanol water fraction decreased compared with the control group. Conclusion Temu putih fraction can reduce the amount, motility, morphology, and viability of spermatozoa in male rats. Keywords: Fraction, Temu Putih, Amount of spermatozoa, Motility of spermatozoa, Viability Of Spermatozoa
The Relationships Between Single Nucleotide Polymorphisme (rs867500) STX1A Gene Exon 10 and Intelectual Intelligence Dalinur Qur'andini; Yuwono Yuwono; Triwani Triwani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 1 No. 1 (2017): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v1i1.13

Abstract

Background: STX1A consists of 10 exons covering a genome overlay of 20.42 kb (2064 base mRNA) . The location of HPC-1 / Syntaxin 1A is on chromosome 7q11.23. Genes STX1A or HPC-1 or Syntaxin 1A are genes that encode membrane proteins that play an important role in neurotransmitter exocytosis in nerve cells. Aim of Study: The purpose of this study was to determine the relationship SNP (rs867500) in the gene STX1A Exon 10 with level intellect. Method: This research was observational analytic with cross sectional study design with a population of 368 and a sample of 36 were divided into two groups, namely the above-average IQ and IQ group average. To determine the relationship SNP (rs867500) STX1A gene Exon 10 with a level of intelligence used X2 test (Chi-square). Results: The results showed not found SNPs in genes STX1A exon 10. Conclusion : STX1A Genes can be said to contribute to the collective intelligence of other genes, ie genes and gene IGFR2 FNBPL1 although there is no STX1A gene polymorphism in exon 10. Keywords: Gene STX1A Exon 10, polimorphism, SNP, intelectual, intelligence.