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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kesehatan Andalas Global Medical and Health Communication Biomedical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Majalah Kedokteran Andalas Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Majalah Kedokteran Neurosains Human Care Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ners Science Midwifery Nusantara Hasana Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Journal of Pharmaceutical and Sciences. Neurona Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Yuliarni Syafrita
Department Of Neurology, Faculty Of Medicine, Universitas Andalas, Padang, Indonesia.
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Journal : Cermin Dunia Kedokteran

 1 
Hubungan Usia Penderita Stroke Iskemik dengan Kadar Beta-amyloid Plasma Syafrita, Yuliarni
Cermin Dunia Kedokteran Vol 42, No 10 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.498 KB) | DOI: 10.55175/cdk.v42i10.954

Abstract

Latar Belakang: Ketidakseimbangan antara produksi, pemecahan, dan clearance beta-amyloid (Aβ) merupakan proses patofisiologi awal penumpukan beta-amyloid di jaringan otak. Tujuan penelitian ini adalah melihat hubungan antara usia dan kejadian stroke iskemik terhadap kadar beta-amyloid plasma. Metode: Penelitian cross-sectional bersifat observasional, membandingkan kadar beta-amyloid plasma di kelompok usia muda, usia lanjut sehat, dan usia lanjut yang mengalami stroke iskemik. Hasil: Kadar Aβ40 plasma pada usia muda lebih tinggi dibandingkan pada usia lanjut sehat (p=0,011). Kadar Aβ40 pada usia lanjut sehat lebih tinggi dibandingkan pada usia lanjut yang mengalami stroke (p<0,001). Kadar Aβ42 plasma pada usia muda lebih tinggi dibandingkan pada usia lanjut sehat (p=0,002). Kadar Aβ42 pada usia lanjut yang mengalami stroke jauh lebih tinggi dibandingkan pada usia lanjut sehat (p<0,001). Simpulan: Kadar Aβ40 dan Aβ42 plasma pada usia muda lebih tinggi dibandingkan pada usia lanjut sehat. Pada pasien usia lanjut dengan stroke iskemik usia lanjut, kadar Aβ40 plasma lebih rendah dan kadar Aβ42 plasma lebih tinggi dibandingkan pada usia lanjut sehat.Background: The imbalance of production, degradation, and clearance of beta-amyloid is an early pathophysiological process responsible for the accumulation of beta-amyloid in the brain tissue. The purpose of this study is to find out the association between age and events of ischemic stroke, and plasma beta-amyloid. Methods: Observational cross-sectional study to compare beta-amyloid plasma levels among younger age, healthy elderly, and the elderly suffering from ischemic stroke. Results: The plasma level of Aβ40 in the younger age is significantly higher than in the healthy elderly (p=0.011). The plasma level Aβ40 in the healthy elderly is significantly higher than in the post ischemic stroke elderly (p <0.001). The plasma level of Aβ42 in younger age is higher than in the healthy elderly (p=0.002). The plasma level of Aβ42 in the elderly who experienced stroke is higher than in the healthy elderly (p<0.001). Conclusion: The plasma level Aβ40 and Aβ42 are higher in younger age compared to the healthy elderly. In the elderly with ischemic stroke, the plasma level of Aβ40 was lower and level of Aβ42 was higher compared to the healthy elderly.
Hubungan Usia Penderita Stroke Iskemik dengan Kadar Beta-amyloid Plasma Yuliarni Syafrita
Cermin Dunia Kedokteran Vol 42, No 10 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i10.954

Abstract

Latar Belakang: Ketidakseimbangan antara produksi, pemecahan, dan clearance beta-amyloid (Aβ) merupakan proses patofisiologi awal penumpukan beta-amyloid di jaringan otak. Tujuan penelitian ini adalah melihat hubungan antara usia dan kejadian stroke iskemik terhadap kadar beta-amyloid plasma. Metode: Penelitian cross-sectional bersifat observasional, membandingkan kadar beta-amyloid plasma di kelompok usia muda, usia lanjut sehat, dan usia lanjut yang mengalami stroke iskemik. Hasil: Kadar Aβ40 plasma pada usia muda lebih tinggi dibandingkan pada usia lanjut sehat (p=0,011). Kadar Aβ40 pada usia lanjut sehat lebih tinggi dibandingkan pada usia lanjut yang mengalami stroke (p<0,001). Kadar Aβ42 plasma pada usia muda lebih tinggi dibandingkan pada usia lanjut sehat (p=0,002). Kadar Aβ42 pada usia lanjut yang mengalami stroke jauh lebih tinggi dibandingkan pada usia lanjut sehat (p<0,001). Simpulan: Kadar Aβ40 dan Aβ42 plasma pada usia muda lebih tinggi dibandingkan pada usia lanjut sehat. Pada pasien usia lanjut dengan stroke iskemik usia lanjut, kadar Aβ40 plasma lebih rendah dan kadar Aβ42 plasma lebih tinggi dibandingkan pada usia lanjut sehat.Background: The imbalance of production, degradation, and clearance of beta-amyloid is an early pathophysiological process responsible for the accumulation of beta-amyloid in the brain tissue. The purpose of this study is to find out the association between age and events of ischemic stroke, and plasma beta-amyloid. Methods: Observational cross-sectional study to compare beta-amyloid plasma levels among younger age, healthy elderly, and the elderly suffering from ischemic stroke. Results: The plasma level of Aβ40 in the younger age is significantly higher than in the healthy elderly (p=0.011). The plasma level Aβ40 in the healthy elderly is significantly higher than in the post ischemic stroke elderly (p <0.001). The plasma level of Aβ42 in younger age is higher than in the healthy elderly (p=0.002). The plasma level of Aβ42 in the elderly who experienced stroke is higher than in the healthy elderly (p<0.001). Conclusion: The plasma level Aβ40 and Aβ42 are higher in younger age compared to the healthy elderly. In the elderly with ischemic stroke, the plasma level of Aβ40 was lower and level of Aβ42 was higher compared to the healthy elderly.
Co-Authors Adang Bachtiar Afriyeni Sri Rahmi Ahmad, Baihaqi Alya Ramadhini Andi Fadilah Yusran Andy, Marfri Anggi Anugerah Basir ATTIYA ISTARINI Basjiruddin Ahmad Cintya Agreayu Dinata Darwin Amir Darwin Amir Darwin Amir, Darwin Dedi Sutia Dhiang Mulia Syofiadi Djong Hon Tjong Dwi Sri Rejeki Dwitya Elvira, Dwitya Elsi Rahmadhani Hardi Elvia Fataya Ennesta Asri Erdanela Setiawati Eryanti, Lusi Eva Chundrayetti Eva Decroli Fadel Muhammad Fadrian, Fadrian Fanny Adhy Putri Fitra Ermila Basri Gunawan Septa Dinata Haiga, Yuri Harun Harnavi Hauda El Rasyid Hendra Permana Husni Minanda Fikri Indra, Syarif Iqbal Al Rasyid Istiqomah Jabbar, Ridho Ahmad Karina Prasasti Helhid Kurniawan, Yoga Setia Lydia Susanti Lydia Susanti Lydia Susanti Lydia Susanti Lydia Susanti, Lydia M Hasan Machfoed Marfri Andy Marliana, Lesti Meldayeni Busra Mubarak, M. Dzaky Muhammad Farhan Khadaffi Mustafa Noer Nailatul Fadhilah Nela Novita Sari Netti Suharti Nora Fitri Nora Fitri Novi Yudia Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nurhayati Nurhayati Nurvalinda, Nurvalinda Pitra, Dian Ayu Hamama Putri, Fanny Adhy Rahmi Ulfa Rasyid, Hauda El Ratna D Siregar Rauza Sukma Rita Reno Bestari Reno Bestari Restu Susanti Rika Susanti Rika Susanti Rini Gusya Liza, Rini Gusya Rizanda Machmud Rizki Muhammad Rananda RR. Ella Evrita Hestiandari Russilawati, Russilawati Salmiah Agus Sukri Rahman Susila Sastri Susila Sastri Sutia, Dedi Syahrul, Muhammad Zulfadli Syarif Indra Syarif Indra Trya Mia Intani Widia Rahmawati Yantri Maputra Yanwirasti Yanwirasti Yaumi Faiza Yoga Setia Kurniawan Yulia Trisna