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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) JMM (Jurnal Masyarakat Mandiri) Pharmasipha Martabe : Jurnal Pengabdian Kepada Masyarakat Jambura Journal of Health Sciences and Research Jambura Journal of Chemistry Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Indonesian Journal of Pharmaceutical Education Indonesian Community Journal Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products
Mahdalena Sy Pakaya
UNIVERSITAS NEGERI GORONTALO
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Indonesian Journal of Pharmaceutical Education

 1 
UJI POTENSI ANTIBAKTERI EKSTRAK BATANG GAHARU (Gyrinops versteegii) TERHADAP BAKTERI Escherichia coli dan Staphylococcus aureus Sy. Pakaya, Mahdalena; Mustapa, Moh. Adam; Ali, Muthiah Rahmah
Indonesian Journal of Pharmaceutical Education Vol 1, No 3 (2021): September 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i3.11417

Abstract

Penyakit infeksi merupakan salah satu masalah kesehatan yang paling utama di Indonesia maupun di negara-negara berkembang lainnya. Kontaminasi mikroba berkaitan dengan penyebab infeksi tersebut. Infeksi dapat disebabkan oleh berbagai mikroba seperti bakteri, virus, jamur, dan protozoa. Salah satu tumbuhan berkhasiat obat yang berada di Indonesia adalah gaharu (Gyrinops versteegii). Penelitian ini bertujuan untuk mengukur potensi ekstrak batang gaharu (Gyrinops versteegii) terhadap bakteri Escherichia coli dan Staphylococcus aureus. Dimana simplisia batang gaharu diekstraksi menggunakan metode maserasi bertingkat dengan pelarut n-Heksan, etil asetat dan metanol. Hasil uji aktivitas antibakteri terhadap 3 ekstrak tersebut yaitu ekstrak etil asetat mampu menghambat pertumbuhan Escherichia coli dan Staphylococcus aureus. Hasil skrining ekstrak etil asetat mengandung alkaloid, terpenoid dan tanin. Kontrol positif yang digunakan yaitu kloramfenikol dan kontrol negatif yaitu Dimetil Sulfoksida (DMSO). Hasil Uji KHM ekstrak batang gaharu terhadap Escherichia coli dan Staphylococcus aureus yaitu pada konsentrasi 50% ditandai dengan tidak terjadi kekeruhan dan 50% untuk nilai KBM dimana tidak terjadi pertumbuhan bakteri pada media Nutrien Agar (NA). Hasil Uji Potensi ekstrak etil asetat batang gaharu terhadap Escherichia coli pada konsentrasi 25%, 50%, dan 100 % dengan zona hambat yang dihasilkan yaitu 7,85 mm dimana masuk dalam kategori sedang, 10,6 mm dan 13,45 mm dimana masuk dalam kategori kuat. Sedangkan uji potensi ekstrak etil asetat batang gaharu terhadap Staphylococcus aureus pada konsentrasi 25%, 50%, dan 100 % dengan zona hambat yang dihasilkan yaitu 8,1 mm dimana masuk dalam kategori sedang, 13,2 mm dan 16 mm dimana masuk dalam kategori kuat dalam menghambat bakteri. Infection disease is one of the most common health problem in many developing countries, including Indonesia where the contamination of microbe is associated with the cause of the infection. The infection can be caused by various microorganisms such as bacteria, virus, fungus, and protozoa. Fortunately, Indonesia’s medicinal plant varies and one of which is agarwood (Gyrinops versteegii). This study aims at measuring the potential of agarwood (Gyrinops versteegii) stem extract towards Escherichia coli and Staphylococcus aureus. In this study, the simplicial of agarwood stem is extracted by applying multilevel maceration method with n-Hexane solvent, ethyl acetate, and methanol. The result of antibacterial activity testing over three extracts reveals that the ethyl acetate extract can inhibit the growth of Escherichia coli dan Staphylococcus aureus. In addition, the result of screening in the ethyl acetate extract discovers that in contains alkaloid, terpenoid, and tannin, where the positive control used is chloramphenicol and the negative control is Dimethyl Sulfoxide (DMSO). The result of Minimum Inhibitory Concentration test in the agarwood stem extract towards Escherichia coli dan  Staphylococcus aureus shows that the concentration of 50% is marked with absence of turbidity, whereas 50% in the Lowest Lethal Dose value signifies absence of growth in the bacteria in the Nutrient Agar (NA) media. Additionally, the result of potential test of agarwood stem ethyl acetate extract towards Escerichia coli in concentrations of 25%, 50%, and 100% with an inhibition zone created of 7,85 mm where it includes in medium category, and 10,6 mm and 13,45 mm that include in strong category. In the meantime, the result of potential test of agarwood stem ethyl acetate extract towards Staphylococcus aureus in concentrations of 25%, 50%, and 100% with an inhibition zone created of b,1 mm where it includes in medium category, and 13,2 mm and 16 mm that include in strong category in inhibiting bacteria.
UJI TOKSISITAS EKSTRAK DAUN KENCUR (Kaempferia galanga L) DENGAN METODE BRINE SHRIMP LETHALY TEST (BSLT) sy pakaya, mahdalena; hasan, hamsidar; umar, linsih
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022 (in press)
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.11283

Abstract

One of the plants that has potential as medicine is kencur(Kaemoferia galanga L). Many studies have asserted that the rhizome of kencur is useful for bacterial infections, cough medicine, dysentery, cold, and stomachache. Therefore, the research aimed to identify the toxic effect of kencur leaf extract on artemia salina larvae applying the BSLT (Brine shrimp lethaly test) method. It employed three concentration treatments using 10 artemia salina larvae that died after 48 hours. Futher, it was calculated by LC50with probit analysis. The result of probit analysis revealed that the value of LC50from n-hexane extract was 96,13µg/mL, ethyl acetate extract was 98,22 µg/mL and methanol extract of kencur leaf was 156,06 µg/mL. The LC50 value of the extract was in the active category, with the value of LC50was lower than 1000 ppm.
STANDARISASI DAN KADAR FLAVONOID TOTAL EKSTRAK ETIL ASETAT KULIT BATANG NANGKA (Artocapus heterophylus L) Niluh Sri Purnama; Hamsidar Hasan; Mahdalena Sy Pakaya
Indonesian Journal of Pharmaceutical Education Vol 1, No 3 (2021): September-Desember 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i3.11140

Abstract

Nangka (Artocarpus heterophylla L) adalah tumbuhan yang banyak terdapat di Indonesia. Hampir seluruh bagian pohon nangka dapat dimanfaatkan sebagai obat herbal dimana senyawa flavonoid terprenilasi merupakan metabolit sekunder utama yang terdapat dalam genus Artocarpus. Di Indonesia penggunaan obat herbal masih bersifat tidak terukur baik dari segi takaran, maupun proses penyiapannya. Sehingga perlu dilakukan standarisasi hal ini dilakukan untuk menjaga konsistensi serta keseragaman dari bahan obat herbal. Penelitian ini bertujuan untuk menentukan parameter standarisasi spesifik dan non spesifik serta menentukan kadar flavonoid total ekstrak etil asetat kulit batang nangka. Metode ekstraksi yang digunakan adalah maserasi bertingkat menggunakan pelarut n-heksan, etil asetat dan metanol. Hasil penelitian mengenai parameter organoleptik dari ekstrak etil asetat kulit batang nangka yaitu berwarna merah kehitaman, bau khas, rasa pahit sepat dengan tekstur kental. Simplisia kulit batang nangka memiliki tiga lapisan warna yaitu abu-abu kehijauan dengan bercak putih, lapisan orange dan lapisan coklat muda dengan permukaan tidak rata dan tebal kulit batang kurang lebih 1 cm, serbuk simplisia kulit batang nangka memiliki fragmen kristal oksalat bentuk prisma, serabut, jaringan gabus hablur, dan  parenkim dengan amilum. Ekstrak etil asetat mengandung senyawa flavonoid, dan alkaloid. Dan parameter non spesifik ekstrak etil asetat kulit batang nangka yaitu kadar air 16,97%, susut pengeringan 10,48%, kadar abu 9,78%, kadar abu tidak larut asam 1,58% dan bobot jenis 0,912. Dengan kadar flavonoid ekstrak etil asetat adalah 28,1025 µg/mL.
Formulasi dan Evaluasi Stabilitas Fisik Sediaan Krim Senyawa Astaxanthin Robert Tungadi; Mahdalena Sy. Pakaya; priliya wati d.as'ali
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.14612

Abstract

This study aims to formulate and evaluate the preparation of an anti-aging cream made from astaxanthin. Astaxanthin has antioxidant activity, as well as other carotenoid compounds. Astaxanthin shows more significant antioxidant activity than ?-carotene; thus,developing astaxanthin compounds in cream preparations is necessary. This type of experimental laboratory research compares three different concentrations of astaxanthin compounds, including formula I (0.5%), formula II (0.75%), and formula III (1%). Evaluation of the astaxanthin compound cream preparations stability included organoleptic observations (smell, color, texture), pH test, homogeneity test, viscosity test, spreadability test, adhesion test, and freeze-thaw test. The results of the quality inspection of organoleptic preparations revealed no difference between the preparations in the form of color, smell, and texture.The homogeneity test showed a homogeneous preparation; the pH test produced was 5.5-5.8, the viscosity test of the preparation produced was 5140 Cp, 5250 Cp, and 7000 Cp, the adhesion test was 6.40-7.83 seconds, the dispersion test was 5-5.9 cm, and the Freeze-thaw test showed that there was no significant change in the pH test, organoleptic test, spreadability, adhesion, homogeneity, and viscosity. Thus, it can be concluded that the three astaxanthin compound cream formulas have good stability.
Analisis Kualitatif Metabolit Sekunder dan Aktivitas Antioksidan Jamur Endofit Cangkang Bulu Babi (Diadema setosum) Widy Susanti Abdulkadir; Mahdalena Sy. Pakaya; Fika Nuzul Ramadhani; Wiwit Zuriyati Uno; Arona Salama
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.18019

Abstract

Endophytic fungi are fungi that live in plant tissues for a certain period and can form colonies in the host's tissues without endangering the host itself. In addition to plants, endophytic fungi are also found in marine biota. Endophytic fungi that live in the internal organs or tissues of marine biota, whether in the form of mold or yeast, can transform the nutrients they obtain from their host animals into metabolite compounds which will then be transferred back to the host organs so that they have the same metabolites as their hosts. This study aimed to analyze and test the antioxidant activity of the secondary metabolites of sea urchins in the Tomini Bay area. The method used from the beginning of the research was endophytic microbial fermentation, production of secondary metabolites, and partitioning of endophytic microbial isolates, namely liquid-liquid; the method used to test antioxidant activity was qualitative using TLC plates, DPPH UV-Vis spectrophotometer method, color reagent, and thin layer chromatography. Two isolates of endophytic fungi were obtained, namely (JBB1, JBB2). The isolate that was active as an antioxidant was JBB2 from sea urchins in the Tomini Bay area with an ICso 50-100 ppm, which was in the strong category. Meanwhile, JBB2 isolate was carried out at a wavelength of 517 nm with a value absorbance of 0,707 A. In accordance with the value of the linear equation, it obtained y = 0,092x+36,95 and an R2 value = 0,945 that the ethyl acetate extract in JBB2 had a moderate ICs of 87.43 µg/mL. Meanwhile, the qualitative test of secondary metabolites using thin layer chromatography with n-hexane eluent: ethyl acetate (8:2) ethyl acetate extract contained alkaloid and terpenoid compounds.
SKRINING FITOKIMIA DAN UJI DAYA HAMBAT EKTRAK DAUN JAHE MERAH (Zingiber officinale var rubrum) TERHADAP BAKTERI Staphylococcus Epidermidis DAN Escherichia Coli Ibrahim, Annisa Humairah; Hasan, Hamsidar; Sy. Pakaya, Mahdalena
Indonesian Journal of Pharmaceutical Education Vol 1, No 2 (2021): Mei-Agustus 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i2.10547

Abstract

Infectious disease is one of the diseases caused by microbes, including bacteria. Staphylococcus epidermidis and Escherichia coli are gram-positive and gram-negative bacteria that cause infectious diseases. The selection of medicinal plants as an alternative solution is an effective way of reducing the resistance of bacteria. Based on the empirical data, herbal plants with antimicrobial potential are red ginger (Zingiber officinale var rubrum). This research aimed to determine the inhibition test on Staphylococcus Epidermidis and Escherichia coli due to phytochemical compounds contained in the leaves of red ginger which serve as an antibacterial. Through this experimental laboratory research, a crude drug was extracted using n-hexane, chloroform, ethyl acetate, and methanol solvent. The phytochemical screening results of n-hexane extract showed that red ginger leaves contain alkaloids and terpenoids; chloroform extract contains alkaloids, steroids, and tannins; ethyl acetate extract contains alkaloids, steroids, flavonoids, and tannins; and the methanol extract contains alkaloids, terpenoids, flavonoids, and tannins. Chloramphenicol and Dimethyl sulfoxide (DMSO) were used as the positive control and negative control respectively. Inhibition test results were obtained from the four n-hexane extracts, chloroform extracts, ethyl acetate extracts, and methanol extracts with three different concentrations.The results obtained the greatest inhibition against Staphylococcus Epidermidis bacteria, namely at a concentration of 20% chlorform extract of red ginger leaves as large as 18,90 mm. Meanwhile, the inhibition of Escherichia Coli is at a concentration of 20% n-hexane extract with an inhibitory power of 17,84 mm inhibition zone that is classified as a strong category to inhibit the growth of bacteria .The results of the One Way ANOVA data analysis (p less than 0.01) with a confidence level of 99%.
Hubungan Pengetahuan dan Sikap terhadap Tindakan Pemilihan Obat Untuk Swamedikasi Madania, Madania; Sy. Pakaya, Mahdalena; Papeo, Pirdawati
Indonesian Journal of Pharmaceutical Education Vol 1, No 1 (2021): Januari-April 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i1.9948

Abstract

One of the curative efforts often carried out by the community is self-medication. Self-medication is one of the efforts in treating symptoms of illness or illness that is being suffered by someone without consulting a doctor in advance. Self-medication in its implementation cannot be separated from the use of traditional medicine and modern medicine. This study aimed to measured the correlation between the knowledge and attitude of the people of Tontulow village, North Sulawesi, regarding the tradisional medicine and modern medicine towards their act of selecting the type of medicine for self-medication. This study was an observational study with a cross sectional design. The sampling technique was performed by cluster sampling method. The instrument of  the study was using questionnaire. For normality tes used Klomogrov-Smirnov test while for the correlation test used Pearson test. The number of participants were 83 respondents. Most of the people of Tontulow village have a sufficient level of knowledge regarding the traditional medicine and modern medicine, as many as 67 respondents (80.7%) with their attitude tended to be positive towards both medicine type. There was a correlation between knowledge and attitude regarding the tradisional medicine and modern medicine towards the act of selecting medicine type (the result of Pearson test: significance value less than 0,05)
Identifikasi Drug Related Problems (DRPs) Pasien Hipertensi di RS Multazam Kota Gorontalo Tuloli, Teti S.; Sy. Pakaya, Mahdalena; dwi pratiwi, susi
Indonesian Journal of Pharmaceutical Education Vol 1, No 1 (2021): Januari-April 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i1.9945

Abstract

Hypertension is a disease that continues to increase every year, where the keys to success for its treatment are selection and use of the drugs. The treatment failure occurred if the selection and use of medication are inappropriate with the condition of patients followed by DRPs. Unresolved hypertension can cause heart attack, kidney failure and stroke. The research aimed to identify DRPs at hypertension patients with or whitout comorbidity reviewed from the drug without indication, indication without drug, high doses, low doses, and drug interaction. The research was non-experimental descriptive research which applied cross-sectional design by collecting data through a retrospective at hypertension with or without comorbidity at Multazam Hospital of Gorontalo City for January-December 2018 periods. The samples were selected by purposive sampling and obtained 79 patients who were qualified as samples. The obtained data were analyzed with univariate. The finding of research showed that the use of medication at hypertension patient with or without comorbidity at Multazam Hospital of Gorontalo City for January-Desember 2018 periods based on five categories were drug without indication was 3.08%, indication without drug was 33,84%, high doses was 27,70%, low doses was 4,62% and drug interaction was 30,76%. The identification of DRPs of use of hypertension medication with or without comorbidity at Multazam Hospital of Gorontalo City for January-December 2018 periods was categorized good.
Co-Authors A. Mu’thi Andy Suryadi Abas, Siti Nur Rahmatiya Abdullah, Rahayu Anatasya Putri Ade Ari Puspitadewi Akuba, Juliyanti Ali, Muthiah Rahmah alkatiri, ahmad alkatiri AM Andy Suryadi AM. Andy Suryadi Andi Makkulawu Ar’syifa Wijaya, Hudan Ariani H. Hutuba Arista Idris, Pinkan Arona Salama Basri, Rakhmadana Fitraeni Datukramat, Hendrawan Dwikarunia Dewa Ayu Puspita Dewi Rahmawaty Moo djuarno, endah nurrohwinta Djuwarno, Endah Nurrowinta Dr. Apt. Hamsidar Hasan S.Si.,M.Si dwi pratiwi, susi Endah Nurrohwinta Djuwarno Fajar Dwi Agung Fatimah Azzahra Fazril Pakaya, Mohamad Fika Nuzul Ramadhani Grasela Mbae Hamsidar Hasan Hamsidar Hasan Hartati Hartati Hiola, Faramita Hiola, Paramita Hunawa, Rachmawaty Dirham I Made Hariadi Wijaya Ibrahim, Aliya Ibrahim Ibrahim, Annisa Humairah Jihan Astuti Kai Julianty Akuba Kongkolu, Sitty Rahma Hutami kopman, aldafarista La Ode Aman LATIF, MULTIANI S Latif, Multiani S. Liberto, Frith F. Madania Madania, Madania Madania, Madania Magfirah Nur Cahyani Makkulawu, Andi Manno, Mohamad Reski Maspeke, Khofifa Nurul Magfira Moh. Adam Mustapa Mohamad Adam Mustapa Mohamad Aprianto Paneo Moo, Faradila Ratu Cindana Muhammad Taupik Muhammad Taupik Mustapa, Moh. Adam Muthiah Rahmah Ali Nazwah Buana Putri Kalangi Niluh Sri Purnama Nur Ain Thomas Nur Rasdianah Nurdiandra Jahja pakaya, Handriansyah Pakaya, Meri Isriani Papeo, Dizky Ramadani Papeo, Dizky Ramadani Putri Papeo, Pirdawati priliya wati d.as'ali Puluhulawa, Lisa Efriani Qarlan Pratama, Mohammad Rahmawati Hunawa Ramly Abudi Robert Tungadi S. Latif, Multiani Santi Santi Selvi Marcellia Suryadi, A. Muthi Andi Suryadi,, A. Mu'thi Andy Teti Sutriyati Tuloli Thamrin, Rahmulia Tolulu, Sri Noviani umar, linsih Wicita, Prisca S. Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widysusanti Abdulkadir Wiwit Zuriati Uno Yayah Rachmatiyah Yunus, Fitriah Ayu Magfirah Zahra Zakia, Wavika Zuriati Uno, Wiwit