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All Journal Indonesian Journal of Urology Journal of Biomedicine and Translational Research Majalah Kesehatan FKUB Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Biomolecular and Health Science Journal Indian Journal of Forensic Medicine & Toxicology
Kurnia Penta Seputra
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Biomolecular and Health Science Journal

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The Potential of Cammelia sinensis (Tea Leaves) Active Compound as Alternative Therapy on castrate-resistant prostate cancer (CRPC) with Androgen Receptor Inhibition: In Silico Study Mega Memory Rahasa Putra; Kurnia Penta Seputra
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.32147

Abstract

Introduction: Prostate cancer is a leading global cause of increased mortality and morbidity in men which can be complicated by castrate-resistant prostate cancer (CRPC). Pharmacological therapy by inhibiting the androgen receptor (AR) can inhibit prostate cancer progression. Tea leaves (Camellia sinensis) are believed to inhibit the prostate cancer progression but the mechanism is still unknown. Therefore, research on the mechanism by in silico study is needed with the AR as target protein.Methods: The effectivity of tea leaves’ active compound to inhibit androgen receptor was evaluated by docking server with abiraterone acetate as a control. The tea leaves' active compounds consist of catechin, epicatechin, epigallocatechin gallate, epigallocatechin, gallate epicatechin, gallocatechin gallate, and gallocatechinResults: The result showed that epicatechin, epigallocatechin, and gallocatechin have lower free binding energy (ΔG) and high amino acid residue similarity on AR compared with abiraterone acetate. But, it has lower surface interaction compared with abiraterone acetate. Conclusion: Epicatechin, epigallocatechin, and gallocatechin are predicted to have potential as alternative therapy in CRPC with AR Inhibition.
Co-Authors Aina Angelina Akbar, Fariz Kemal Basuki B. Purnomo Dewi, Rose Khasana Dhani, Fauzan Kurniawan Doddy M Soebadi Ekaputra, Aditya Airlangga Eviana Norahmawati Fabrianta, Dio Mafazi Hamdan Yuwafi Naim Husein, Rahmat Johanes Dwi Meiyanto Kenty Wantri Anita, Kenty Wantri Medianto Mega Memory Rahasa Putra Nurhadi, Pradana Paksi Satyagraha Prabowo, Satria Adji Hady Prasetyo Nugroho Putra, Mega Memory Rahasa Rachmad Sarwo Bekti Rofifa, Amira Fithri Satria, Hikmat Soetojo Soetojo Taufiq Nur Budaya Ulfaningtyas, Kiki Zen A Prasetyo