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All Journal E-Jurnal Medika Udayana Jurnal Vektor Penyakit Meditory : The Journal of Medical Laboratory International Journal of Community Service Learning Journal of Health Sciences Jurnal Peduli Masyarakat Jurnal Sewaka Bhakti Aesculapius Medical Journal Warmadewa Minesterium Medical Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Paradharma: Jurnal Aplikasi IPTEK Physical Therapy Journal of Indonesia
Witari, Ni Putu Diah
Universitas Warmadewa
Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : E-Jurnal Medika Udayana

 1 
THE EFFECT OF NOISE EXPOSURE ON THE AVERAGE NUMBER OF TEMPORAL LOBUS NEURONS IN ADULT WISTAR RATS Suka Astini, Dewa Ayu Agung Alit; Evayanti, Luh Gde; Witari, Ni Putu Diah; Sumadewi, Komang Trisna; Prima Dewi, A.A.A Asri; Anthony Kerans, Fransiscus Fiano; Kurniawati, Ida
E-Jurnal Medika Udayana Vol 13 No 07 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i07.P09

Abstract

Noise is defined as unwanted and disruptive sound, considered an environmental stressor and disturbance. Noise encompasses many aspects of modern communities, including work environments. The damaging effects of noise primarily result from the unrestricted production of free radicals into the auditory organs. Exposure to noise causes various health problems, such as hearing impairment, sleep disturbances, and interference with individual performance. Reactive oxygen species (ROS), also known as free oxygen radicals, are normal by-products of cellular aerobic metabolism. These unstable molecules can damage cellular lipids, proteins, and nucleic acids in DNA if the antioxidant balance is disrupted. Acute and chronic exposure to loud noise generates excessive free radicals and disrupts extra-auditory organs such as the nervous, endocrine, and cardiovascular systems. The purpose of this study is to analyze the relationship between noise exposure and the number of neurons in the temporal lobes of Wistar rats. The research design used is a laboratory experimental design, specifically a pure experimental design, implemented with the randomized posttest-only control group design. The research sample consists of 30 male Wistar rats randomized into 2 groups, control and treatment. The treatment group is exposed to 95dB noise for 4 hours per day for 14 days. The rats are then euthanized, and their brain tissue is fixed with 10% neutral buffered formalin. Assessment is performed using Hematoxylin Eosin staining, and analysis is conducted blindly on the average number of neurons in the rat's temporal lobes. Data is subjected to normality testing using the Shapiro-Wilk test and analyzed using independent t-tests for parametric comparison. The results show a significant difference in the mean number of neurons in the temporal lobes between rats exposed to noise and the control group (p <0.005). The conclusion of this study is that noise affects neuron cells in the temporal lobes. Keywords : noise, temporal lobe, neurons.
EVALUATING THE EFFECTIVENESS OF ANATOMY AND HISTOLOGY PRACTICUM DURING COVID-19 PANDEMIC AT FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS WARMADEWA Evayanti, Luh Gde; Sumadewi, Komang Trisna; Witari, Ni Putu Diah; Suka Astini, Dewa Ayu Agung Alit; Kerans, Fransiscus Fiano Anthony; Dewi, A.A.Ayu Asri Prima; Ekayani, Ni Wayan Diana
E-Jurnal Medika Udayana Vol 13 No 6 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i06.P11

Abstract

The implementation of anatomy and histology practical sessions at Fakultas Kedokteran dan Ilmu Kesehatan (FKIK) Universitas Warmadewa during the Covid-19 pandemic still has many variations. This difference in implementation will have an influence on the achievement of student learning. This research aims to evaluate the knowledge of anatomy and histology among students by giving asynchronous learning, pre-test, post-test and practicum exam. This study using cross-sectional approach. 124 participants are 3th semester students whose active status at FKIK Universitas Warmadewa. The primary data were collected directly from practical sessions and practicum exam. The pre-test and post-test data were analyzed using paired-T test (p<0.05). The post-test and practicum exam were analyzed using Spearman rho (p<0.05). In anatomical practicum, there is an increase in post-test scores when compared to pre-test although not significant (p = 0.119). Anatomical practicum exam results have a meaningful positive correlation with post-tests (p = 0.013, r = 0.22). In histological practicum there was a significant increase in post-test scores when compared to pre-tests (p = 0.013), although practicum exam results were not significantly correlated with post-test (p = 0.410). Based on this study, improvements are needed related to technical of anatomical and histological practicums, as well as provisions related to practicums so that activities are structured
Perbedaan Efektivitas Metformin dan Glimepirid dalam Menurunkan Glukosa Darah Puasa Pasien Diabetes Melitus Tipe 2 di RSD Mangusada Badung Dwiputra, Made Wahyu Dharma; Wijaya, Made Dharmesti; Witari, Ni Putu Diah
E-Jurnal Medika Udayana Vol 12 No 7 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i07.P15

Abstract

Diabetes melitus tipe 2 (DMT2) merupakan penyakit gangguan metabolisme yang ditandai dengan kenaikan kadar glukosa darah akibat gangguan produksi insulin, dan atau gangguan fungsi insulin. Jumlah penderita DMT2 di Indonesia diperkirakan akan meningkat hingga 21,3 juta jiwa pada tahun 2030. Dalam penatalaksanaan farmakologis awal DMT2 dapat diberikan monoterapi metformin atau glimepirid. Penelitian ini bertujuan untuk mengetahui perbedaan efektivitas metformin dan glimepirid dalam menurunkan glukosa darah puasa pasien DMT2 rawat jalan di Rumah Sakit Daerah (RSD) Mangusada Badung. Variabel pada penelitian ini adalah efektivitas metformin dan glimepirid serta kadar glukosa darah puasa. Penelitian ini menggunakan desain analitik observasional dengan studi cross-sectional. Sampel dalam penelitian ini adalah rekam medis penderita DMT2 rawat jalan di Poliklinik Penyakit Dalam RSD Mangusada Badung dengan jumlah 96 orang menggunakan metode non-probability sampling dengan teknik consecutive sampling. Penelitian ini menggunakan instrumen rekam medis pasien DMT2 sesuai dengan kriteria inklusi dan eksklusi. Data dianalisis menggunakan uji statistik parametrik chi-square. Hasil penelitian menunjukan penggunaan monoterapi metformin efektif dalam menurunkan glukosa darah puasa pada 36 pasien (75%), sedangkan monoterapi glimepirid efektif pada 25 pasien (52,1%). Terdapat perbedaan bermakna efektivitas metformin dan glimepirid dalam menurunkan glukosa darah dengan nilai P<0,05. Kesimpulan dari penelitian ini adalah metformin lebih efektif dalam menurunkan glukosa darah puasa dibandingkan dengan glimepirid pada pasien DMT2 rawat jalan di RSD Mangusada Badung.
Co-Authors A A I Ayesa Febrinia Adyasputri A.A. Raka Budayasa A.A.Ayu Asri Prima Dewi Adhitya, I Putu Gde Surya Anak Agung Ayu Istri Prima Dewi Anak Agung Istri Aryastuti Anak Agung Sri Agung Aryastuti Anny Eka Pratiwi Anthony Kerans, Fransiscus Fiano Astini, Dewa Ayu Agung Alit Suka Bayuningrat I Gusti Ngurah Made Cahyawati, Putu Nita Dewa Ayu Agung Alit Suka Astini Dewi, A.A. Ayu Asri Prima Dewi, A.A.Ayu Asri Prima Dewi, Anak Agung Ayu Asri Prima Dwiputra, Made Wahyu Dharma Ekayani, Ni Wayan Diana Erly Sintya Evayanti, Luh Gede Fransiscus Fiano Anthony Kerans Hegard Sukmawati, Ni Made I Gede Ananta Widjaksana I Gusti Ayu Avinya Chintya Devi I Made Adi Putra Wiguna Ida Kurniawati, Ida K Tangking Widarsa Kadek Ananda Pratama Putra Kerans, Fransiscus Fiano Anthony Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Triyani Kartinawati Luh Gde Evayanti Luh Gede Evayanti Luh Gede Pradnyawati Made Dharmesti Wijaya Ni Kadek Elmy Saniathi Ni Luh Putu Eka Kartika Sari Ni Luh Putu Putri Ni Nyoman Sunariasih Ni Wayan Aurelia Niriswari Darmawan Ni Wayan Rusni Ni Wayan Widhidewi Peranawa, I Wayan Yoga Diva Pradnyawati, Luh Gede Prima Dewi, A.A.A Asri Putu Asih Primatanti Ratna Juwita, Dewa Ayu Putu Saktivi Harkitasari Sueta, Made Agus Dwianthara Suka Astini, Dewa Ayu Agung Alit Sumadewi, Komang Trisna Wangsa, Putu Gde Hari