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Widodo Priyanto

Faculty of Pharmacy, Setia Budi University

Author-ID : 3552597

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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Pengaruh Bahan Pengikat Gelatin dalam Formula Tablet Ekstrak Daun Kemuning (Murraya paniculata (L.) Jack) secara Granulasi Basah Yeni Fitriana; Titik Sunarni; Widodo Priyanto
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Kemuning (Murraya paniculata (L.) Jack) is one of Indonesia medicine plants. Kemuning leaves can be used to decrease cholesterol. The experiment was aimed to make tablets of kemuning leaves extract with gelatin as binding agent that fulfilled the requirements of tabletâ€™s physical quality. Extract of kemuning leaves was obtained from kemuning leaves powder by maceration method using ethanol 70%. The obtained extract was soaked for several days and then evaporated till thick extract was obtained. Kemuning leaves extract tablets were made in 3 formulation with difference concentrations of binding agent, i.e. formula I contained 1% of gelatin mucilage 5%, formula II contained 2% and formula III contained 3%. The method used to make tablets of kemuning leaves extract was wet granulation method. The obtained granules were physically tested in cluding flowing time, the angle of repose, and loss on drying. The obtained tablets were physically tested including weight homogeneity, hardness, friability and disintegration time. The obtained data was statistically analyzed using SPSS 11.0 for windows program i.e. one way anova added with one factor at 95% convidence. The conclusion of the experiment was that kemuning leaves extract could be made tablets that fulfilled therequirement of tabletâ€™s physical quality. The result of the experiment showed that the three formulations produced tablets with weight homogeneity, hardness, friability and disintegration time that fulfilled the requirement of good physical quality of tablet.

Optimasi Formula Tablet Effervescent Ekstrak Kelopak Bunga Rosela Dengan Kombinasi Avicel PH 101 Dan Gelatin (Aplikasi Metode Simplex Lattice Design) Widodo Priyanto
Jurnal Farmasi Indonesia Vol 8 No 2 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Avicel PH 101 is an excipient in tablet making that can be used as diluent, binder, lubricant, and disintegrator. Avicel is not economically an advantage so that it needs to be combined with cheaper materials. Combination of Avicel PH 101 with gelatin starch is able to accelerate the disintegration time of the effervescent tablet. Rosela (Hibiscus sabdariffa L) rose is a traditional medicine that is used as antiinflammation. The study was to find out the optimum proportion of Avicel PH 101 and gelatin mixture in effervescent tablet making of rosella rose extract by simplex lattice design method. The extract of rosella rose was obtained by maceration of rosella rose powder with ethanol 70%. The obtained extract was evaporated until a thick extract was obtained. Effervescent tablet formulation was based on SLD method with excipients of Avicel PH 101 (A) and gelatin (B) i.e. F1 (100% A), F2 ( 50% A : 50% B), F3 (100% B). The effervescent tablets of rosella rose extract were made by a direct compression methods. Physical characteristic test of the tablets included weight uniformity test, hardness test, friability test, disoluble time test and taste perception test. The equation was used to make effervescent tablets with total respond of the most optimum granules physical properties. The data of the physical properties of granules from optimum formula as calculation result based on SLD equation with the experiment result was analyzed using T-test. Effervescent tablets from optimum formula were physically tested including weight uniformity, hardness, friability and taste perception test. The result of the experiment indicated that the mixture of 90% Avicel PH 101 â€“ 10% gelatin produced an optimum result in granules physical properties and the obtained effervescent tablets of rosella rose extract fulfilled tablet physical property test.

Pengembangan dan Evaluasi Formulasi dari Tablet Kunyah Nanopartikel Mebendazol Muhammad Dzakwan; Widodo Priyanto
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Mebendazole is a benzimidazole derivative with broad spectrum anthelminthic activity and excellent tolerability. Orally it is rapidly absorbed and metabolized to sulfoxide and sulfone, which may be responsible for its anthelminthic action. This research aimed to formulate mebendazole nanoparticle chewable tablet to increase its dissolution velocity and impact saturation solubility. Mebendazole nanoparticle chewable tablets (300 mg) were prepared by direct compression. The tablets prepared by this method were evaluated by different parameters such as average weight, hardness, friability, disintegration, drug content and in vitro dissolution etc. All the parameters were found within the specifications. The study on the dissolution profile revealed that F1 had better dissolution rate while compared to F2, F3 and mebendazole microparticle, respectively. Assay values were within the limits of 90% to 110%.

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Journal : Jurnal Farmasi Indonesia