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All Journal JURNAL GIZI INDONESIA Nurse Media Journal of Nursing UG Journal Journal of Nutrition College Forum Agribisnis Journal of Consumer Science Mutiara Medika: Jurnal Kedokteran dan Kesehatan The Indonesian Biomedical Journal ELT Forum: Journal of English Language Teaching Journal of Consumer Sciences Jurnal Ilmu Keluarga dan Konsumen Journal of Innovative Science Education Medica Hospitalia Jurnal Health Sains Jurnal Keperawatan Klinis dan Komunitas (Clinical and Community Nursing Journal) Neurona Seroja Husada: Jurnal Kesehatan Masyarakat Jurnal Info Kesehatan Eko-Regional: Jurnal Pembangunan Ekonomi Wilayah Eko-Regional: Jurnal Pembangunan Ekonomi Wilayah
Retnaningsih Retnaningsih
Departemen Ilmu Keluarga dan Konsumen Fakultas Ekologi Manusia Institut Pertanian Bogor
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Journal : Seroja Husada: Jurnal Kesehatan Masyarakat

 1 
CORRELATION OF TNF-ALFA INFLAMMATION BIOMARKER LEVELS WITH THE INDONESIAN VERSION OF MONTREAL COGNITIVE ASSESSMENT (MOCA-INA) SCORES IN LAKUNAR ISCHEMIC STROKE PATIENTS Hamdani, Faishol; Hartono, Jimmy Eko Budi; Tugasworo, Dodik; Retnaningsih, Retnaningsih; Suryawati, Herlina; Puspitawati, Arinta
Seroja Husada: Jurnal Kesehatan Masyarakat Vol. 1 No. 5 (2024): Seroja Husada: Jurnal Kesehatan Masyarakat
Publisher : Seroja Husada: Jurnal Kesehatan Masyarakat

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Abstract

Background: Tumor Necrosis Factor-Alpha (TNF-α) is a pro-inflammatory cytokine that is responsible for modulation the immune system. TNF-α is another important mediator involved in stroke pathophysiology. Cerebral small vessel disease (CSVD) is a major cause of lacunar ischemic stroke. In stroke there is an increase in TNF-α levels where post-stroke neuroanatomic damage can cause cognitive impairment. Objective: Proving the relationship between TNF-α serum levels on the day 3 of onset and the Moca Ina score on the day 7 of onset, day 30, and the difference in MoCa-INA scores and analyzing the relationship of risk factors cognitive function in lacunar ischemic stroke patients. Methods: An analytical observational study with a prospective cohort approach. Subjects were first-time lacunar ischemic stroke with blood sampling on the day 3 of onset to evaluate TNF-α levels. Cognitive function was examined by the MoCa-INA score which was evaluated on day 7 and day 30. Eta correlation test to connect TNF-α levels with MoCa-INA scores. Bivariate and multivariate analyzes used between the MoCa-INA score and other confounding factors. Results: There was a strong correlation between TNF-α levels on day 3 of onset and MoCA-INA on day 7 (ƞ= 0.972), a very strong correlation was found between TNF-α levels on day 3 of onset and MoCA-INA on day 30 (ƞ= 1,000), and there was a strong correlation between TNF-α levels on day 3 of onset and the difference between MoCA-INA (ƞ=0.905). there is a confounding variable diabetes mellitus that affects the 7th day of MoCA-INA. In the sub-analysis study, the mean serum TNF-α level on cognitive impairment on day 30 was higher than on day 7 with the most dominant domains being visuospatial and executive. Conclusion: There is a strong relationship between serum TNF-α levels and MoCa-INA scores in lacunar ischemic stroke patients, and there is one confounding variable of diabetes mellitus that affects the MoCa-INA score on the 7th day of examination.
Co-Authors Afina, Siti Agung, Locoporta Aisy, Rihadatul Al Mutanafisa, Tasneem Alfiasari Amalia Khairati Amin Husni Andhitara, Yovita Andhitara, Yovita Andhitara Ani Ruwani, Ani Anita Saufika Anjani, Gemala Ardhini, Rahmi Arifin Triyanto Arina Hayati Asep Taryana Budisulistyo, Trianggoro Caroline, Maria Daynuri, Daynuri Diah Retno Wahyuningrum Dini Aprilia Dodik Tugasworo Drajat Martianto Dwi Febryanto Endang Gumbira Sa’id Erni Hernawati Purwaningsih, Erni Hernawati Fadila Ramadini Febriantina Dewi Fibria Mustikarini, Fibria Firina Firina Firli Bramantyo, Dion Fitri Octaviana Fitria Handayani Hajijah, Rengganis Novyanti Hamdani, Faishol Handaru Tri Mulyono Hanisa Rahmina Fitriyana Hartono, Jimmy Eko Budi Hartoyo Hartoyo Irni Rahmayani Johan Istiqlaliyah Muflikhati Jaeri, Santoso Jethro Budiman, Jethro Junedi, Rahmat Juswanto, Gerard Kurnianto, Aditya Kurnianto, Aditya Kurnianto Lia Yuliana Lilik Noor Yuliati Martha Irene Kartasurya Megawati Simanjuntak Nana Rochana, Nana Nani Maharani Noni Widiawatie Nuraini Nuraini Pasmanasari, Elta Diah Priambada, Dody Purba, Jan Sudir Puspitawati, Arinta Putri, Ayulia Karisma Putri, Marietta Krisnaya Nandika Putri, Nadya Yona Eka Rahmawati, Dani Rahmayanti Rahmayanti Rahmi Parhati RIA ANGGRAINI Saiful Ridlo Satrioaji, Hari Wahono Sofro, Muchlis AU Achsan Udji Sri Anna Marliyati Suryadi Suryadi Suryawati, Herlina Syahrul Syahrul Tamad, Fatiha Sri Utami Tri Rahayu, Fitriani Tri Subekti Trisnaningtyas, Wenny Tsaniadi Prihastomo, Krisna Tugasworo, Dodik ` Tyas, Ayuning Ujang Sumarwan W.H, Nugrahaningsih Wahyuni, Ribut Nurul Tri Widaryanti, Widya Bella Yudiatma, Muh. Firman Yuridis, Melani Sukma