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All Journal Jurnal Ilmu Kimia Universitas Brawijaya Research Journal of Life Science Natural B The Journal of Pure and Applied Chemistry Research Jurnal Teknologi Laboratorium Jurnal Riset Agribisnis dan Peternakan JKPK (Jurnal Kimia dan Pendidikan Kimia) JSMARTech : Journal of Smart Bioprospecting and Technology Makara Journal of Science
Anna Roosdiana
Chemistry Department, Brawijaya University Jalan Veteran, Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Veterinary Other

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Journal : The Journal of Pure and Applied Chemistry Research

 1 
Evaluation of Bioactive Compounds, Release Profiles, and Toxicity Test from Microcapsules Containing R. tuberosa L. Extracts Utilizing Gum Arabic Almayda, Nabila; Roosdiana, Anna; MASRURI, Masruri; Safitri, Anna
The Journal of Pure and Applied Chemistry Research Vol. 13 No. 1 (2024): Edition January-April 2024
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2024.013.01.3336

Abstract

This study is essential to analyze the toxicity and release of bioactive compounds in R. tuberosa L. extract microcapsules coated with gum Arabic and to provide information on the use of microcapsules as a drug delivery system with controlled release of active ingredients. Investigations focused on the effect of pH and timing on discharge kinetics, as well as toxicity evaluation. The release of active ingredients from microcapsules was carried out in medium variations, namely pH 2.2 and pH 7.4, with release durations of 30, 60-, 90-, 120-, and 150-min. Bioactive compounds were released by 59.23% at pH 2.2 and 58.21% at pH 7.4 within 150 min. The BSLT (brine shrimp lethal toxicity) assay was used using brine shrimp larvae (Artemia salina L.), resulting in a non-toxic classification as evidenced by an LC50 value of 5729 μg/mL. Microcapsules in optimum conditions were then characterized using FTIR (Fourier-Transform Infrared) and SEM (scanning electron microscopy) instruments. The FTIR analysis showed variations in functional groups in R. tuberosa L. extracts, gum Arabic, and microcapsules. Furthermore, the SEM examination highlighted the morphology of microcapsules that were mostly spherical.
Immobilization of Cutinase from Fussarium oxysporum into Sea Sand Matrix for Catalytic Degradation of Polyethylene Terephthalate (PET) Prameswari, Tira P. K.; Sutrisno, Sutrisno; Roosdiana, Anna
The Journal of Pure and Applied Chemistry Research Vol. 13 No. 1 (2024): Edition January-April 2024
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2024.013.01.3325

Abstract

Cutinase is an enzyme that can be used as a catalyst in the hydrolysis reaction of polyethylene terephthalate (PET) waste into terephthalic acid and ethylene glycol. Generally, cutinase has low stability in its free form. Therefore, to increase cutinase stability, cutinase needs to be immobilized. In this study, cutinase was immobilized into a sea sand matrix by adsorption technique. The purpose of this study was to determine the optimum conditions of PET hydrolysis (pH, temperature, and incubation time), and to study the ability of immobilized cutinase for catalytic degradation of PET. The results show that immobilized cutinase has optimum conditions at pH 8, temperature of 50 °C, and incubation time of 24 hrs. Moreover, the immobilized cutinase can be used for up to three cycles with a residual activity percentage of 66.2% and an activity value of 23.224 nmol. g-1. min-1. The total enzyme activity of immobilized cutinase after being used in three cycles was 89.99 nmol. g-1. min-1 or 28.6% of its free enzyme activity.
Co-Authors A.A. Ketut Agung Cahyawan W Adyatama Ardian Akhmad Kholisul Fuad Akramsyah, Muhammad Ali Almayda, Nabila Amri, Indah Amalia Aulanni'am, Aulanni'am Ayunda Arum Sari Chanif Mahdi Dameanti, Fidi Nur Aini Eka Puji Diah Mardiana Edi Sukmana Elvanila Tanjung Fahmiantika, Reza fatchiyah . Firmawati, Aulia Herawati Herawati Iftakhul Mufarrikha Imaroh Isya intan permata sari Izofani, Safira Janatun Na’imah Jusak Nugraha Kurniasari, Balqis Larasati, Luckyta Retno Masruri Masruri Mufida, Fadillah Prameswari, Tira P. K. Pratama, Alfaro Rikko Pratama, Dyah Ayu Oktaviani A Pratama, Dyah Ayu Oktavianie Ardhiana Purwanta, Marijam Putri Dewi Rendy, Achmad Nur Rifa’I, Muh Husni Rosmanansari, Novia Sintesa Dara Safitri, Anna Salamah, Alfi Sari, Dewi Ratih Tirto Sasangka Prasetyawan Satriana Satriana Selvi Marcellia Sutrisno, Rahayu Sutrisno, Sutrisno Tantowidjojo, Vanessa Rachmani Tedja, Dhaneswara Thaati, Hayyunisa Widyanti, Marta Wijaya, Anik Sri Windari, Hema Aprilia Setyo Winthoko, Eka Nora Vitaloka Aprilia Putri