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All Journal Pharmascience Jurnal Ilmu Kefarmasian Indonesia Proceeding of Mulawarman Pharmaceuticals Conferences
Kartiningsih Kartiningsih
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Jurnal Ilmu Kefarmasian Indonesia

 1 
Karakterisasi Nanopartikel dan Uji Antiagregasi Platelet Secara In-Vitro terhadap Ekstrak Rumput Laut Coklat (Sargassum polycystum) Hasil Hidrolisis Enzim Sellulase Kartiningsih Kartiningsih; Syamsudin Abdillah; Partomuan Simanjuntak; Cyntia Cyntia; Haryo Haryo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (478.048 KB) | DOI: 10.35814/jifi.v17i2.720

Abstract

Brown seaweed contains fucoidan, a large molecular weight sulfate polysaccharide (about 100,000 Da) which has platelet antiagregation activity. This activity is achieved if the fucoidan has a small molecular weight (3900-7600 Da) so this activity can increase by hydrolized with sellulase Enzym. The purpose of this study was to obtain extract nanoparticles that meet physical quality requirements and have a higher platelet antiagregation activity than brown seaweed extract both before and after hydrolysis. Extraction was using kinetic maseration method using 80% ethanol after that using 2% calcium chloride solution. The results were dried and hydrolyzed with cellulase enzyme and nanoparticles were made by ionic gelation method. Nanoparticle characterization results in particle size of 552.8, polydispersity index of 0.569, potential zeta of +53.5 mV, and spherical shape. In-vitro testing results for platelet antiagregation activity showed the percentage of platelet aggregation inhibition of brown seaweed extract with a concentration 500µg / mL is 22.19% and extracts after hydrolysis was 57.94% and nanoparticles extract after hydrolysis was 72.93%. Extract nanoparticles meet physical quality requirements and extracted nanoparticles after hydrolysis have the highest platelet antiagregation activity compared to brown seaweed extract both before and after hydrolysis.
Formulasi Krim Minyak Biji Bunga Matahari (Helianthus annuus L.) dengan Variasi Konsentrasi Setil Alkohol sebagai Anti Jerawat Lusiana Ariani; Nur Miftahurrohmah; Kartiningsih Kartiningsih; Meilisa Ang
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.828

Abstract

Acne is an inflammatory condition that was caused by Propionibacterium acnes. Sunfl owerseeds (Helianthus annuus L.) with terpenoids and linoleic acid could prevent and treat acne. In theprevious study, sunfl ower seed oil had a Minimum Inhibitory Concentration (MIC) value for P. acnesbacteria ≥1.5% with a Diameter Inhibitory Zone 15.27 mm which was classifi ed as a strong antibacterialagent. This study was intended to develope cream formula (F1-F4) using variations of cetyl alcoholconcentrations of 8, 10, 12% and blanko respectively. The creams were formulated by heating the waterphase and the oil phase separately at 70˚C, then stirred to form the cream. The prepared formulations wereevaluated for organoleptic, homogeneity, type of cream, viscosity and rheology, spread ability, globulesize, centrifugation, and pH. The organoleptic results showed that the cream was white, odorless, softin texture and homogeneous with the type of oil in water (O/W) cream. The viscosity test showed thatthe viscosity of F1-F3 formulas were 490.29; 3886.29; 22510.67 cP and F4 of 111.04 cP with plasticthixotropic fl ow properties. Formula F1-F4 had a spread ability of 8.9; 5,4; 4,4; 7.3 cm2, the globulesizes were 137.78; 133,33; 151.11; 94.44 μm, did not show phase separation during centrifugation andthe pH of the F1-F3 formula were 6.3 and F4 was 5.93. It may be concluded that the evaluation of thephysical and chemical quality of sunfl ower seed oil cream are within the acceptable standard.
Co-Authors . Syamsudin Anarisa Budiati Cyntia Cyntia Haryo Haryo Lusiana Ariani Meilisa Ang Meilisa Meilisa Miftahurrohmah, Nur Partomuan Simanjuntak Rika Damayanti