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All Journal Indonesian Journal of Tropical and Infectious Disease Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Journal Technology and Implementation Bussines PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Teknologi dan Terapan Bisnis Jurnal Pengabdian pada Masyarakat Ilmu Pengetahuan dan Teknologi Terintegrasi Jurnal Teknologi dan Terapan Bisnis Borneo Journal of Pharmacy Jurnal Widya Medika
Achmad Fuad Hafid
Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Ilmu Kefarmasian Indonesia

 1 
Aktivitas Antimalaria Ekstrak Kulit Batang Cempaka Kuning Terhadap Plasmodium Falciparum 3D7 NI PUTU ARIANTARI; NI LUH RUSTINI; LIDYA TUMEWU; ACHMAD FUAD HAFID; ATY WIDYAWARUYANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Cempaka kuning (Michelia champaca) which is belongs to Magnoliaceae family, has been traditionally used for treatment fever. This research was conducted to evaluate antimalarial activity of Cempaka kuning stembark extract against Plasmodium falciparum 3D7 in vitro. Cempaka kuning stembark was extracted with n-hexane, chloroform and methanol yielded n-hexane extract, chloroform extract and methanol extract, followed by antimalarial activity assay of these extracts. Phytochemical screening showed that n-hexane extract contain volatile oil and terpenoids, chloroform extract contain Volatile oil, terpenoids and fiavonoids, then methanol extract contain volatile oil, terpenoids, flavonoids, tannins and glycosides. Result of this study also showed that n-hexane extract, chloroform extract and methanol extract were active against P. alciparum 3D7 in vitro, with an IC50 value of 0.36, 0.24 and 1.00 µg/mL. The findings indicate that Cempaka kuning stembark extracts possess strong antimalarial activity and are prospective to be developed as antimalarial.
Efek Pemberian Dosis Berulang dan Dosis Tunggal Ekstrak Kulit Batang Cempedak (Artocarpus Champeden Spreng.) Pada Mencit Terinfeksi Plasmodium Berghei SOFIANA SARI; ACHMAD FUAD HAFID; ATY WIDYAWARUYANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Artocarpus champeden Spreng. (Moraceae) known as “cempedak”, was traditionally used for antimalarial remedies in Indonesia. Study to determine antimalarial activity of ethanol extract of cempedak stembark was carried out. Artocarpus champeden Ethanol Extract (ACEE) was administered twice per day (multiple dose) and once per day (single dose) orally. The study was carried out by modification method of the “4 Days Suppressive Test” originally described by Peter. The result showed that ACEE administered twice per day inhibited parasites growth (ED 0.19 mg/kg BW) higher than once per day (ED 6.0 mg/kg BW) and 10 mg/kg body weight of dose administrated twice per day was more effective than 100 mg/kg body weight once per day.
Co-Authors Abdul Rahman Adita Ayu Permanasari, Adita Ayu Arif Basofi Ario Imandiri, Ario Artiarini Kusuma Nurindiyani Aty Widyawaruyanti Corry, Maylisa Natalia Darmawan Aditama Djoko Agus Purwanto Edhi, Narendrani Sasmitaning Einstenia Kemalahayati Fardani Annisa Damastuti Fifi Maghfirotun Nisa Handayani, Rosita Hanifah Khairun Nisa Hasan, Muhammad Amir Hidayati, Agriana Rosmalina Hidayatus, Laila Nur Hilkatul Ilmi Hilkatul Ilmi Hilkatul Ilmi Ilmi, Hilkatul Indah Tantular Kasmawati, Henny Lahardo, Devanus Laura Wihanto Lidya Tumewu Malaka, Muhammad Hajrul Maria Lucia Ardhani Dwi Lestari Marsih Wijayanti Melanny Ika Sulistyowaty Mufid, Mohammad Robihul Myrna Adianti Ni Luh Rustini Ni Putu Ariantari Nike Puliansari Nur Illiyyin Akib Nur Suci Lestari Nur Syaela Majid Purwitasari, Neny Retno Widyowati Riesta Primaharinastiti, Riesta Rina Puspitasari Rini Hamsidi Sabar Deyulita Sabarudin Sabarudin Saniyatul Mawaddah SOFIANA SARI Suciati Suciati Suciati Suciati Sudjarwo Sudjarwo Sukardiman Tri Widiandani Tutik Sri Wahyuni Utami Islamiati W Wahyuni, W Wicaksana, Firman Widyowati, Rr. Retno Wiwied Ekasari