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All Journal Jurnal Sain Veteriner Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional Pharmascience JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

Moch. Saiful Bachri

Fakultas Farmasi, Universitas Ahmad Dahlan Yogyakarta

Author-ID : 368642

Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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EFEK TOKSISITAS FRAKSI ETIL ASETAT AKAR SENGGANI (Melastoma affine D.Don ) PADA ORGAN HEPAR, GINJAL DAN TESTIS Saiful Bachri, Moch.
PHARMACIANA Vol 1, No 1: Mei 2011
Publisher : PHARMACIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB)

Senggani (Melastoma affine D.Don) merupakan tanaman yang banyak ditemukan di wilayah Asia tenggara dan China. Tanaman ini banyak di gunakan sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui efek toksik senggani terhadap organ-organ vital. Sejumlah 32 ekor tikus jantan jenis Wistar di bagi menjadi 5 kelompok. Kelompok Kontrol (n=8 ), kelompok Fraksi Etil asetat akar senggani (FEAS) dosis 62.5 mg/kgBB (n=6 ), dosis 125 mg/kgBB (n=6), dosis 250 mg/kgBB (n=6), dosis 500 mg/kgBB (n=6). Kelompok kontrol disuntik secara per oral dengan bahan pensuspensi FEAS yaitu CMC Na 0.5 %. Pemberian fraksi etil asetat akar senggani selama 22 hari. Pada hari ke-23 dilakukan pembedahan dan dilakukan pemeriksaan histopatologik pada organ testis, ginjal dan hepar. Hasil pengamatan pada ginjal dan hepar, pemberian FEAS untuk semua dosis tidak ada perbedaan dibandingkan dengan kelompok kontrol, sementara pada organ testis pemberian FEAS dosis 250 mg/kgBB dan 500 mg/kgBB menunjukkan terjadinya nekrosis pada tubulus seminiferus dan terlihat jumlah sperma mengalami penurunan. Kesimpulan penelitian ini, pemberian fraksi etil asetat akar senggani menyebabkan efek toksik pada organ testis ditunjukkan dengan adanya nekrosis pada tubulus seminiferus.

EFEK HEPATOPROTEKTIF EKSTRAK METANOL JAHE MERAH (Zingiber officinale Roscoe) PADA MENCIT JANTAN YANG DIINDUKSI CCl4 Saiful Bachri, Moch.
PHARMACIANA Vol 1, No 2: November 2011
Publisher : PHARMACIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB)

Ekstrak MeOH jahe merah (Zingiber officinale Roscoe) telah diteliti efek hepatoprotektif pada dosis 100 mg/kgBB dan 200 mg/kgBB dengan menggunakan metode induksi CCl4. Mencit jantan galur Swiss (25±1,5 g) diberi perlakuan dengan jahe merah (100 mg/kgBB dan 200 mg/kgBB) dan Sillymarin (100 mg/kgBB) selama dua minggu sebelum diinduksi CCl4, 0,5 ml/kgBB secara intraperitonial. Setelah 24 jam mencit dibunuh dan diambil darah melalui vena porta untuk diuji aktivitas SGPT dan SGOT. Hasil penelitian menunjukkan bahwa aktivitas SGPT dari ekstrak MeOH jahe merah dengan dosis 100 mg/kgBB dan 200 mg/kgBB, Sillymarin, kontrol, dan normal berturut turut, (34,51±5,3427) (38±4,28) (27,26±1,06) (36,61±1,87) dan 25,37±2,01 IU/L. Sedangkan aktivitas SGOT dari Ekstrak MeOH jahe merah dengan dosis 100 mg/kgBB dan 200 mg/kgBB, Sillymarin, kontrol dan kelompok Normal berturut turut, (88,88±0,94) (83,88±3,91) (83,99±7,24) (92,97±8,16) (82,99±3,97)U/L. Ekstrak MeOH jahe merah dosis 200 mg/kgBB dan Sillymarin secara signifikan (p < 0,05) dapat menurunkan aktivitas SGPT dan SGOT. Dari hasil penelitian menunjukkan bahwa ekstrak MeOH jahe merah mempunyai efek hepatoprotektif.

The gastroprotective effects of canna edulis ker. tuber starch on peptic ulcer and the histopathological profile of rat stomach Najini, Robby; Bachri, Moch Saiful; Yuliani, Sapto
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ganyong rhizome (Canna edulis Ker.) empirically use for treating gastritis (peptic ulcers). Ganyong rhizome contains carbohydrates and flavonoid that can reduce inflammation in the gastric tissues and againsts free radicals that are contributing to the pathogenesis of peptic ulcers. This research aims to know the gastroprotective effect of ganyong rhizome on white female rats, Wistar strain, which were given alcohol (ethanol 96%) by dose 1 ml/200gBB and measuring the total flavonoids content in ganyong rhizome. This research is Post Test Only Control Group Design, using 30 rats, weight 150-200 g, age 6-8 weeks, health condition. It is divided into six groups. Group I (normal) were fed and watered only, Group II (control) were given a CMC-Na 0,5%, Group III-V were given a suspension of ganyong rhizome starch (SGRS) with each doses 250, 500, and 1000 mg/kgBB, then Group VI were given a sucralfate dose 360 mg/kgBB. Rats were given oral treatment for 14 days. An hour after the treatment on 14th day, the whole groups unless the group I were given ethanol 96% 1 ml/200gBB orally. Twenty four hours later the rats were sacrificed, dissected and taken its gastric for further analyzed the number of ulcers as well as the description of histopathology of the gastric. The results showed that ganyong rhizome starch can decrease the index ulcer and increase the protection ratio value to the control group with results of doses SGRS 250, 500, 1000 mg/kgBB sequentially i.e., 12,5; 50; and 75%. The description of histopathology also showed significant improvement of gastric tissue at a dose of 1000 mg/kgBB. In addition, on TLC-Densitometri test also obtained the total flavonoid compound in ganyong rhizome is 112,49 Â± 7,97 ppm. Conclusions of this research are that the ganyong rhizome positive contains flavonoid and it has gastroprotective effect by decreasing the number of index ulcer, increasing the protection ratio value, and improving the histopathology of gastric tissue which had given alcohol.

EFEK HEPATOPROTEKTIF SERBUK AKAR PASAK BUMI (Eurycoma longifolia Jack.) DILIHAT DARI AKTIVITAS SGPTSGOT TIKUS JANTAN YANG DIINDUKSI CCl4 Adikusuma, Wirawan; Bachri, Moch. Saiful
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This study was designed to evaluate the hepatoprotective effect of the powder Eurycomalongifolia Jack. From the activity level of SGPT-SGOT on CCl4-induced in male rats. Twentyfive male rats (150-250 g) divide in to 5 groups. Group I treated with aquadest was kept asnormal, group II treated with a single dose of CCl4 (1 ml/ kg BW i.p), group III and IV weretreated with Eurycoma longifolia Jack. (100 mg/kg BW and 200 mg/kg BW p.o) respectivelyand CCl4 (1 ml/kg BW i.p), group V treated with a single dose of curcumin (100 mg/kg BWp.o) and CCl4 (1 ml/kg BW i.p). Blood was collected from vena porta for determination ofSGPT-SGOT. The study showed the activity level of SGPT from the rats was treated byEurycoma longifolia Jack. 100 mg/kg BW and 200 mg/kg BW, Curcumin, and control groupsare 150.0Â±5.099 U/L; 113.6Â±5.508 U/L; 60.5Â±2.887 U/L; and 129.0Â±6.055 U/L respectively. Mean while the activity level of SGOT from the rats was treated by Eurycoma longifolia Jack.100 mg/ kg BW and 200 mg/ kg BW, Curcumin, and control groups are 369.4Â±11.165;263.0Â±1.803; 194.5Â±7.448; and 451.5Â±16.759 U/L respectively. The Eurycoma longifoliaJack. powder and Curcumin significantly (p < 0.05) declines two enzymes (SGPT and SGOT)than control group. The results concluded that Eurycoma longifolia Jack. powder hashepatoprotective effect.

EFEK HEPATOPROTEKTIF EKSTRAK METANOL JAHE MERAH (Zingiber officinale Roscoe) PADA MENCIT JANTAN YANG DIINDUKSI CCl4 Bachri, Moch Saiful
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

MeOH extract of Zingiber officinale Roscoe (ZO) were investigated forhepatoprotective effect at the doses (p.o) of 100 and 200 mg/kg body weight using CCl4induction method. Male Swiss mouse (25Â±1,5 g) were treated with ZO doses 100 and200 mg/kg bw and Sillymarin (100 mg/kg bw) for two week before treatment with asingle dose of CCl4, 0.5 ml/kg bw, intraperitoneally. The mouse were sacrifactivity ofSGPT-SGOT. The study showed the activity of SGPT of MeOH extract of ZO doses 100mg/kg bw and 200 mg/kg bw, Sillymarin, control and normal groups are (34,51Â±5,34)(27,38Â±4,28) (27,26Â±1,06) (36,61Â±1,87) dan (25,37Â±2,01I) U/L. respectively. Whilethe activity of SGOT of MeOH extract of ZO doses 100 mg/kg bw and 200 mg/kg bw,Sillymarin, control and normal groups are (88,88Â±0,94) (83,88Â±3,91) (83,99Â±7,24)(92,97Â±8,16) (82,99Â±3,97) U/L.respectively. MeOH extract of ZO dose 200 mg/kg BWand Sillymarinsignificantly (p < 0,05) decrease the activities two enzymes (SGPT andSGOT). The results showed MeOH extract Zingiber officinale Roscoe hashepatoprotective effect.

EFEK TOKSISITAS FRAKSI ETIL ASETAT AKAR SENGGANI (Melastoma affine D.Don ) PADA ORGAN HEPAR, GINJAL DAN TESTIS Bachri, Moch Saiful
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Melastoma affine (MA) is a medicinal plant commonly found in south East Asiaand China. The aim of the study is to investigate the toxicity effect of MA toward vitalorgans. Thirty two Wistar adult male rats were divided into five groups consisting of sixanimals each the rats in group except control group, eight animals. The rats in group I(control) were administered 0.5% CMC Na orally, while CMC Na suspension of ethylacetate fraction of MA root (62.5, 125, 250,and 500 mg/kg body weight) were given tothe II, III, IV and V groups, respectively. The CMC Na suspensions of ethyl acetatefraction of MA root were administered for 22 days. Rats were sacrificed at the 23th day.Liver, kidney, testis were collected for histopathological observation. The observationresult on liver and kidney showed no difference compare to control groups, meanwhileon testis, the administration of ethyl acetate fraction of MA root at dose (250, 500 mg/kgbody weight) caused necrosis on seminiferus tubules and decreasing sperm counting.The conclusion, administration of ethyl acetate fraction of MA root caused toxicityeffect on testis with necrosis on seminiferus tubules.

Potensi ekstrak etanol 70% akar saluang balum (Lavanga sarmentosa blume kurz) terhadap kualitas dan viabilitas sperma mencit Syarif, Yaumi Musfirah; Bachri, Moch Saiful; Nurani, Laela Hayu
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The present study tried to investigate potency of L. sarmentosa root extract on quality and viability of mice sperm.This study used 25 Swiss male mice were randomly divided into five experimental groups of 5. The ethanolic extract of L. Sarmentosa (100, 200, 400 mg/kg b.w/days), control and X-gra were administered orally for 14 days. The animals were evaluated for sperma quality (sperm count and sperm motility) and viability at 14 days treatment. The results showed that administration of L.sarmentosa roots extract significantly increasing the sperm count (970x106cell/mL) at 400 mg/kg b.w/days (P 0.0040). The extract dose of 200 mg/Kg b.w and 400 mg/Kg b.w had the highest motility values (95%). Viability of sperm are 83.8%; 96.0%; 87.8% respectively at a dose of 100 mg/kg b.w, 200 mg/kg b.w and 400 mg/kg b.w. Present finding oral administration ofÂ L. sarmentosa roots extract has a potency of the quality and viability of mice sperm.

PENGARUH PEMBERIAN EKSTRAK ETANOL DAN KLOROFORM DAUN SIRSAK TERHADAP KOLESTEROL TOTAL DAN TRIGLISERIDA PADA TIKUS YANG DIINDUKSI ALOKSAN Firmansyah, Deni; Bachri, Moch Saiful; Nurkhasanah, Nurkhasanah
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Annona muricata plant is a medicinal plant using by research and drug for human healthy including diabetes mellitus. This research aimed to determine the effect of ethanol extract and chloroform extract of the sirsak leaf as antidiabetes mellitus. This research was conducted in 9 groups of male Wistar rats consisting of 5 rats per group, consisting of normal control, alloxan control, glibenclamide control dose of 10 mg/Kg BW, group of ethanol extract sirsak leaf dose of 50 mg/Kg BW; 100 mg/Kg BW; 200 mg/Kg BW, and group of chloroform extract sirsak leaf dose of 50 mg/kg BW; 100 mg/Kg BW; 250 mg/Kg BW. Tests carried out for 2 weeks. It also conducted assays of total flavonoids and histopathological tests of pancreatic Î² cells. Results of this research showed that the ethanol extract ofÂ sirsak leaves dose of 200 mg/Kg BW has activity in decreasing blood glucose levels better than any other group. Results of the ethanol extract and chloroform extract all doses except the ethanol extract treatment group dose of 200 mg/kg BW and 100 mg/kg BW after a 14-day look is still high triglyceride levels and decrease in total cholesterol (TC) were seen in all group Ethanol extract dose of 200 mg / kgBWÂ has a good potential to reduce levels of triglycerides and total cholesterol. The conclusion of this research is the ethanol extract of sirsak leaf have activity antidiabetic mellitusand decreased total cholesterol.Â

Gastroprotective effect of Canna edulis Ker. ethanolic extract in piroxicam-induced rats Dara Pranidya Tilarso; Moch. Saiful Bachri; Wahyu Widyaningsih
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Medications derived from plants and pure natural ingredients have far lower side effects and risks than synthetic drugs. One side effect of piroxicam is irritation of the digestive tract. One of the therapeutic preventions to minimize peptic ulcers was utilizing Canna edulis Ker. This study aims to prove that ethanolic extract of Canna edulis Ker. can be used as an alternative to prevent piroxicam-induced peptic ulcers based on ulcer index parameters and the protection ratio. The rats were divided randomly into 6 groups consisting of 5 rats. The normal group was given food and water. The negative control group was given 0.5% CMC-Na. The extract groups were given various doses of ethanolic extract ofÂ Canna edulisÂ Ker. (50, 100, and 200 mg/kg BW). The positive control was given sucralfate at 360 mg/kg BW dose. Rats were treated orally for 14 days. One hour after the treatment on the 14th day, all groups except group I were orally administered with piroxicam dissolved in 0.5% CMC-Na at 1.8 mg/kg BW dose. Twenty-four hours later, animals were sacrificed, dissected, and their stomach organs were removed to analyze its number of ulcers. Ulcer observation was formed by giving a score and protection ratio. The mean ulcer index value was 0.33Â±0.58 for 50 mg/kg BW and 100 mg/kg BW ethanol extract treatment groups, while the 200 mg/kg BW group showed 0.67Â±0.58. The protection ratio was 83.33Â±28.87 in 50 mg/kg BW and 100 mg/kg BW treatment groups, while Â 66.67Â±28.87 was shown in the 200mg/kg BW group. Canna edulisÂ Ker. ethanolic extract has the gastroprotective ability by decreasing the index of gastric ulcers and increasing the protection ratio to the stomach of piroxicam-induced rats.

The gastroprotective effects of arrowroot tuber starch (Maranta arundinacea L.) on ethanol-induced gastric damages in rats Vella Lailli; Moch Saiful Bachri; Wahyu Widyaningsih
Pharmaciana Vol 10, No 1 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Empirically, arrowroot tubers (Maranta arundinacea L.) have been widely used in the treatment of gastric ulcers. They are known to contain carbohydrates and flavonoids that play a role in reducing inflammation. This study sought to identify the gastroprotective effects of arrowroot tuber starch (Maranta arundinacea L.) on the ulcer index, % protection ratio, and the histopathological image of Wistar rat models of gastric ulcers. The test animals were divided into six groups. Group I was given free access to food and water (normal control), while Group II was given ethanol without treatment (negative control). Groups III, IV, and V were treated with arrowroot tuber starch at the doses of 125, 250, and 500 mg/kg BW, respectively. Group VI was given sucralfate at the dose of 400 mg/kg BW (positive control). All treatments were administered orally for 14 days and followed by 24 hours of fasting. On Day 15, all groups, except for the normal control, were given 96% ethanol orally at the dose of 1 ml/200gr BW. After one hour, they were dissected, and their stomach was removed for further analyses. The results showed that the administrations of arrowroot tuber starch at 125, 250, and 500 mg/kg BW produced ulcer indices of 2, 1.25, and 1.5, respectively, smaller than the negative control (4.25), and % protection ratios higher than the positive control. The histopathological imaging showed that the stomach of rats receiving arrowroot tuber starch at 250 mg/kg BW presented no pathological changes. Based on these findings, the arrowroot tuber starch is proven to have the ability as a gastroprotective agent.

Co-Authors -, Nova Anggreni Anak Agung Gede Sugianthara Anggreni, Nova Annisa Fatmawati Ardilla, Mita Baroroh, Faridah Cipta Khairunnisa Citra Ariani Edityaningrum, Citra Danang Prasetyaning Amukti Dandy Annas Muttaqien Dara Pranidya Tilarso Daru Estiningsih Daud, Intan Deni Firmansyah Desi Iswahyuni Dian Prasasti Fauziyyah, Khusna Fita Sari Fitri Rahmania Farikha Galuh Rista Putri Haafizah Dania Hestuning Winda Maharani, Hestuning Winda Humolungo, Dwi Tiva Widyanti Sidik Ichwan Ridwan Rais Imono Argo Donatus, Imono Argo Intan Dwi Rahmita Laela Hayu Nurani Ma'ruf, Muhammad Maghfirah, Rahmayani Maharani, Hestuning Winda Marini Marini Muhammad Ma'ruf Muhammad Reza Ramadhani Muhammad Yusron Maulana El-Yunusi Nadia Selvia Najini, Robby Nofa Risma Azis Nur Mahdi Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Risqika Y.T. Paramidhita Sapto Yuliani Sapto Yuliani Sofina Rahmadita Sri Mulyaningsih Subagus Wahyuono Suci Kurniati Suwijiyo Pramono Syarif, Yaumi Musfirah Vella Lailli Damarwati Vivi Sofia Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Widyasari Putranti Wiki Yuli Anita Wirawan Adikusuma

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