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Journal : The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

Helicobacter pylori Antral Density More Valuable than Corporal Density in Chronic Gastritis Patients Bernadetta Jonan; Willy Sandhika; Ummi Maimunah; Muhammad Miftahussurur
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 2 (2019): VOLUME 20, NUMBER 2, August 2019
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (513.789 KB) | DOI: 10.24871/202201973-77

Abstract

Background: Helicobacter pylori has the capacity to colonize in stomach. In countries with a high prevalence of H. pylori, biopsy specimens must be obtained from corpus and antrum to elevate the accuracy. However, in a country with low prevalence of H. pylori such as Indonesia, the sensitivity of antrum specimen only is still questionable. We compared the density of H. pylori in the antrum and corpus of Indonesian gastric biopsy.Method: We conducted a prospective, cross-sectional, and observational study in thirty-two samples of corpus and antrum biopsy tissues from Pathology Anatomy Laboratory. The samples were stained by Modified Giemsa or Diff Quik. Updated Sydney System is utilized to classify the density of H. pylori.Results: Among 32 biopsy specimens from corpus and antrum, it has been statistically proven that H. pylori density in antrum and in corpus has a significant difference (65.5% vs. 15.6%, p 0.001). The density of H. pylori in antrum is mild predominant (43.8%), while the density in corpus is normal predominant (87.5%). Thus, the antral H. pylori infection was the predominant site. In 53.12% case, H. pylori was found in antrum but was not found in the corpus. In 6.24% case, H. pylori was found in both sites, but the density was higher in antrum. Importantly, no case with H. pylori infection in corpus only was found.Conclusion:  H. pylori density in antrum is higher than in corpus. Only a small advantage to use additional biopsy from corpus to detect H. pylori in Indonesia.
Gastric Mucosa Plasma Cells is Unspecific for Diagnosing Helicobacter pylori Infection Gilda Hartecia; Willy Sandhika; Ummi Maimunah; Muhammad Miftahussurur
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 2 (2019): VOLUME 20, NUMBER 2, August 2019
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (585.981 KB) | DOI: 10.24871/202201982-86

Abstract

Background: A high density of Helicobacter pylori is believed to trigger an accumulation of plasma cells in the gastric mucosa. This accumulation stimulated the production of antibodies, causing high antibodies titer being circulated in the blood. The aims of this study is to identify the correlation between the number of plasma cells and H. pylori density in gastric mucosa.Method: This observational analytic study was performed with cross-sectional approach. The samples were the paraffin blocks which consisted of endoscopic gastric biopsy tissues of chronic gastritis patient in Anatomic Pathology Laboratory Dr. Soetomo General Hospital Surabaya in 2017 period. A total of 30 samples were purposively collected. Endoscopic gastric biopsy tissues were stained by two stains, Haematoxylin-Eosin and Modified Giemsa. The examination was performed by experienced pathologist. The correlation between total plasma cells and H. pylori density in gastric mucosa and the difference of total plasma cells between gastric mucosae with different density of H. pylori were determined.Results: There was no significant correlation between total plasma cells and H. pylori density in gastric mucosa. And there was no significant difference of the number of plasma cells found with different density of H. pylori.Conclusion: The number of plasma cells in the gastric mucosa is unspecific for diagnosing H. pylori infection. Other causes associated with plasma cells need to be assessed in further studies.
Co-Authors A.A. Ketut Agung Cahyawan W Afif Nurul Hidayati, Afif Nurul Agung Dwi Wahyu Widodo Agustin Nurliani Aisha Grayli Cahyani Alief Yudo Astuti Alphania Rahniayu Anny Setijo Rahaju, Anny Setijo Ariani, Grace Aries Sasongko Astindari Astindari Astindari Astindari, Astindari Ayu Tyasmara Bagus Haryo Kusumaputra, Bagus Haryo Baiq Ratna Kumaladewi Bernadetta Jonan Betty Agustina Tambunan Brama Rachmantyo Budiono Budipramana, Vicky Sumarki Cita Rosita Sigit Prakoeswa Densy Violina Harnanti Dian Eskaningrum Djoni Susanto Dwi Murtiastutik DYAH FAUZIAH, DYAH Endi Prilansa Mahadi Erlina Erlina Faizah, Zakiyatul Fanny Gunawan Fertilita, Soilia Firda Azizah Gatut Hardianto, Gatut Gilda Hartecia Gondo Mastutik Grace Ariani Hartanto, Felix Hartecia, Gilda Heny Arwati Heriyawati, Heriyawati Heryawati Heryawati I Wayan Yudiana Ibrahim, Azarya Ida Septika Wulansari Ilmiah, Khafidhotul Imam Susilo INDROPO AGUSNI Irene Lingkan Parengkuan Irmadita Citrashanty, Irmadita Isnin Anang Marhana Iswinarno Doso Saputro iwan Syarif Jimmy Hadi Widjaja Jonan, Bernadetta Junita Jeanne Paliman Kartika Arum Wardani Kholida Nur Aini Kiki Apnita Sari Kintan Putri KUSUMASTUTI, ETTY HARY LaleMaulin Prihatina Linda Astari, Linda M. Yulianto Listiawan Mappamasing, Hasnikmah Marina Rimadhani Marina Rimadhani Martha Kurnia Kusumawardani Maylita Sari Maylita Sari, Maylita Meita Ardini Pratamasari, Meita Ardini Muhammad Miftahussurur Nanda Amalia Ramadhanti Navisa, Claudia Clary Nidya Ulfana Tsania Nila Kurniasari Novia Indriyani Adisty Nurina Hasanatuludhhiyah Nurul Wiqoyah, Nurul Poernomo, Adinda Sandya PUNGKY MULAWARDHANA, PUNGKY Purwati Purwati Purwati Puteri, Agnes Ilene Suprapto Qonitatillah, Ana R. Heru Prasetyo R.A. Astrid Putri Wandhita Rahel Yuana Sadikim Ratna Darjanti Haryadi Regina Martina Cilik Ridholia, Ridholia Rizaldi, Fikri Rulisiana Widodo Rusdamayanti Rusdamayanti Rwahita Satyawati Dharmanta Ryski Meilia Novarina Ryski Meilia Novarina, Ryski Meilia S.Pd. M Kes I Ketut Sudiana . Sabilal Alif Sari, Aditya Sita Sari, Festi Artika savitri, Lisa Sawitri Sawitri Sawitri Sawitri Sawitri Sjahjenny Mustokoweni, Sjahjenny Soilia Fertilita Sunarso Suyoso Sunaryo Hardjowijoto Suprabawati, Desak Gede Agung Tessy Badriyah, Tessy Theresia Fifi Judikristiani Tri Hartini Yuliawati Trisniartami Setyaningrum Tyasmara, Ayu Umi Choviva, Farida Ummi Maimunah Vinna Chrisdianti Widati Fatmaningrum Wilda Fitria Rachmadina Windya Tri Hapsari Winona May Hendrata Wiratama, Priangga Adi yasmin, dzakiyah Yusfita Evi Rosdiana