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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia An-Nisbah: Jurnal Ekonomi Syariah INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Pembelajaran Fisika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Journal of Pharmacopolium JURNAL EKONOMI PENDIDIKAN DAN KEWIRAUSAHAAN Martabe : Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Riset Terapan Akuntansi Bali Medika Jurnal Journal of Management - Small and Medium Enterprises (SME's) ABDI MASSA: Jurnal Pengabdian Nasional Indonesian Journal of Networking and Security - IJNS Makara Journal of Health Research Prosiding University Research Colloquium Jurnal Multidisiplin West Science Jurnal Pengabdian kepada Masyarakat Journal of Managerial Sciences and Studies An-Nisbah: Jurnal Ekonomi Syariah Jurnal Kefarmasian Indonesia Neraca: Jurnal Ekonomi, Manajemen dan Akuntansi
Didik Setiawan
Universitas Muhammadiyah Purwokerto
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Journal : Jurnal Kefarmasian Indonesia

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Penggunaan Deksametason pada Pasien COVID-19: Systematic Review dan Meta-analisis Mardhiyyah, Cut Ainul; Setiawan, Didik; Dhiani, Binar Asrining
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.5455

Abstract

COVID-19 is associated with disseminated lung damage in patients, Dexamethasone can reduce lung injury caused by inflammation and there reduce the progression to respiratory failure and prevent death. This systematic review aimed to determine the benefits and safety of Dexamethasone in COVID-19 treatment. The study was performed by a comprehensive literature search which were published in several databases i.e., PubMed, Science Direct, VHL Regional Portal, and ClinicalTrials.gov within the search time of 28 November 2020. Inclusion criteria were articles on the study on COVID-19 patients who received Dexamethasone, observational and experimental studies on the outcomes use evaluation of Dexamethasone. Exclusion criteria are the articles that do not provide control in controlled studies and do not show clear research results on the use of Dexamethasone. An initial search from four databases by entering keywords resulted in 1,046 articles. After screening articles duplication we obtained 835 studies. Finally, 6 articles were obtained after we screened for the article that it can be obtained its full text and 5 articles joined in articles included in the meta-analysis. The analysis showed that Dexamethasone in Covid-19 patients could reduce the incidence of death within 28 days with RR of 0.78 (95% CI 0.57–0.97 P=0.13) compared with Methylprednisolone, Dexamethasone was compared without corticosteroids with RR 0.89 (95% CI 0.82-0.97 P=0.01). Dexamethasone also reduced mechanical ventilator use during treatment with RR 0.95 (95% CI = 0.86-1.05 P = 0.28) compared without corticosteroids. The conclusion from these results: the use of Dexamethasone can reduce the number of deaths in COVID-19 patients, especially severe and critically ill category patients.
Co-Authors . SUSANTI Achmad Saiful Ulum AGUS PRIYANTO Ahmad Syaichoni, Ahmad Amol, Apriance L. Amol, Febriyanti Andi Suhendi Annas, Rafi Nur Antoro, Deny Yudi Arrista, Bella Basleman, Balqis Hisyam Saleh Bella Arrista Binar Asrining Dhiani Bustanuddin As Suaidy Desta Kurniawan, Desta Dharmawan, Putu Oka Dwi Harningsih, Dwi Dwi Lestari Dyah Aryani Perwitasari Eliyanti, Uzma Ellianawati, Ellianawati Febrianti, Fira Rosmaliana Frisky Almuksiti, Frisky Ghulam Asrofi Buntoro Gigih Iryoto, Gigih Hadi, Ismanurrahman Hanafi, Afip Choirul Hasani Siti Alfiyah Heni Lutfiyati, Heni Hidajah Rachmawati Ida Dzikriyani Ika Yuni Astuti Ilone, Stella Indri Hapsari Joko Priyanto Wibowo Juwita, Dina Ratna kartono, Teguh hari Laeli Mustajabah, Laeli Lianawati Lianawati Mahatir, Ashief Mahatir, Ashief Mardhiyyah, Cut Ainul Maulani, Putri Melike Christiani, Melike Michelia Prastika Sugiri Moeslich Hasanmihardja Muamala, Anisa Much Ilham Novalisa Aji Wibowo Muharudin, Eko Nasution , Ahmad Yani Ningrum, Dewi Puspita Nur Ida Dwi Retnani Nur Khoiri Nurhaliza, Inta NURUL AZIZAH Nyoman Sudarma Pradana, Dominicus W Prasuma, Galar Sigit Pri Iswati Utami Purnamasari, Rizky Purnamasari, Rizky Purnamasari, Tri Julia Purnomo, Dwi Kristian Purnomo, Dwi Kristian Ramadhan, Rizal Furqan Ria Utami, Primanitha Riska Octaviana, Riska Rosini, Iin Safitri, Angelia Yuliana Saiful Ulum, Achmad Saputro, Arfindo Adimas Eko Savitri Primasari, Niken Septyana, Dinda Singgih, Aditya Siska Anggita Listiana, Siska Anggita Siti Patonah Soedarso - Soedarso, . Soedarso, . Sri Idayani, Sri Sudarso Sudarso Sugesti Hayuning Tyas, Sugesti Hayuning Sugiantoro, Ergia Andang Sugiri, Michelia Prastika Sukirno Sukirno Supriyadi Supriyadi Suripto Suripto Susanti Susanti Susiyadi, Susiyadi Sutheeraprasert, Praewthip Suwandi S. Sangadji Tyas, Rafi Setyoning Wahyunita Yulia Sari, Wahyunita Yulia Waluyo Budi Atmoko, Waluyo Budi Wasik, Zainul Widya Prilansari, Widya Windu Rujianto, Windu WULAN PURNAMASARI, WULAN Yahya, Muhammad Fachrul Yhoni Agus Setya Mahendra Yudiantoro, Deny Zainul Wasik Zumrotul Anisah, Zumrotul