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Journal : Jurnal Ilmu Kesehatan dan Gizi

Penentuan Kadar Ketoprofen Generik Dan Nama Dagang Dengan Metode Spektrofotometri-UV Rahmi Ayusasmita Gultom; Anny Sartika Daulay
Jurnal Ilmu Kesehatan dan Gizi Vol. 1 No. 3 (2023): Juli: Jurnal Imu Kesehatan dan Gizi
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikg.v1i3.1504

Abstract

Ketoprofen is a non-steroidal anti-inflammatory drug that is used to reduce pain due to inflammation in various rheumatic conditions and degenerative disorders of the skeletal muscle system. In the manufacture of drugs, the examination of the levels of active substances is a requirement that must be met to ensure the quality of the drug. One of the quality requirements is that the content contained must meet the level requirements listed in the Indonesian Pharmacopoeia. The purpose of this study was to determine whether the levels of generic and trade name ketoprofen tablets on the market meet the requirements of the Indonesian Pharmacopoeia levels.This research is descriptive using UV-spectrophotometric method, with 0.1NN NaOH as solvent. The samples used in this study were 4 generic ketoprofen tablets and trade names. The test parameters of this research include Preparation of Standard Parent Solution I (LIB I), Preparation of Solution (LIB II). Determination of maximum wavelength, Determination of linearity of the Calibration Curve and Determination of Ketoprofen levels in tablet preparations. From the test results on samples obtained generic ketoprofen tablets (PT. Hexpharm jaya) of 103.70% ± 0.4280%, ketoprofen tablets with the trade name Kaltropen (PT. Kalbe Farma) of 106.38% ± 0.4879%, tablets Generic ketoprofen (PT. Bernofarm) 102.10%±1.9450%, and generic ketoprofen tablets (PT.Novell) 100.22%±0.8754%. All tablets found met the requirements for the general content, namely the content of the active substance was not less than 99% and not more than 110% of the amount stated on the label.
Co-Authors Afrizani, Afrizani Akbar, Windi Hari Ali Djamhuri Alviana, Liya Anugrah, Bayu Asep Trizaldi Asparyzha, Rhyzha Azri, Atika Cici Andriani Daeng Elysa Putri Mambang Dalimunnthe, Gabena Indrayani Dalimunthe, Gabena Indriyani Dikki Miswanda Dina Agustia Parlin Dina Suciati Saragih Eva Fransiska Fadillah, Nike Fathur Rahman Fatur Rahman fatur Rahman, fatur Fithri Pulungan, Ainil Fitri Mulyani, Fitri Gabena Indrayani Dalimunthe Hafizha, Putri Harahap, Siti Salimah Haris Munandar Nasution Hasanah, Qori Hasrul Abdi Hasibuan Hindri Syahputri Ihsan Fadhilah Leni Handayani Lubis, Minda Sari M. Naufal Rifqi M. Pandapotan Nasution Makhfirah Manik, Umi Chairani Mardhatillah, Wulan Maya Syafira Mayang Sari Ritonga Merani Phaustina Lumban Gaol Miranza, Nona Muhammad Amin Nasution Muhammad Hizbullah Muhammad Wahyudi Munthe, Ariska Nabilla, Alfira nasution, Alfina Tri Utami Nasution, Kartika Zsaskia Nasution, Nur Sahadah Nia Novranda Pertiwi Nst, Haris Munandar Nur Hanifah Nur'ain Harahap Nurhayati Nurhayati Nurul Salsa Abya Ritonga Pasaribu, Mesi Wilia Afrima Pasaribu, Mesi Willia Afrima Putri Intan Sari Putri Theresia Harianja Rafita Yuniarti Rahayu Rahayu Rahmadani Rahmadani Rahmah, Ruhiya Rahmasari, Siti Rahmi Ayusasmita Gultom Retno Sekarini Rezky , Deswita Ina Ricky Andi Syahputra Ridwanto Ridwanto Ridwanto Ridwanto Ridwanto Rika Yuliana, Rika Risma Fauziah Pasaribu Rizki, Rahmad Rosaldi, Hikmah Rossa, Aliffa Sagita Marina Simatupang Sandika, M Teguh Sasnita, Merida Sekarini, Retno Shilvia, Fatin Siagian , Anggi Yani Sinaga, Novita Yulianti Sri Murni Supiyani, Supiyani Syahfitri , Adelya Syahputra, Ricky Andi Syalsabila Putri Tuzzahra, Safira Yayuk Putri Rahayu Yayuk Putri Rahayu Yuniarti , Rafita Yuniarti, Rafita Zulmai Rani