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All Journal Jurnal Matematika & Sains Acta Pharmaceutica Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Current Research on Biosciences and Biotechnology Jurnal Sains dan Kesehatan
Siti Kusmardiyani
Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, ITB
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology

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Journal : Jurnal Sains dan Kesehatan

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Aktivitas Antidiabetes Serbuk Semut Jepang (Tenebrio molitor Linn.) pada Mencit Swiss Webster Jantan yang Diinduksi Aloksan Erwin Samsul; Andreanus A. Soemardji; Siti Kusmardiyani
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.150

Abstract

Diabetes mellitus is a disease caused by metabolic disorders with hyperglycemia conditions that can occur due to impaired insulin secretion, insulin sensitivity or both. Semut Jepang (SJ) are used by people of Indonesians as a drug to reduce blood sugar levels, but have not been scientifically studied as antidiabetic. Therefore, this study aims to examine the antidiabetic activity of Japanese ant powder in mice. Method: The study was carried out using the antihyperglycemic method in mice induced by alloxan. In the antihyperglycemic method in alloxan induced mice, mice were divided into 6 groups, namely 1% normal Na CMC control group (not alloxan induced), 1% Na CMC pain control group (alloxan induced), glibenclamide 5 mg / kg bw comparison group, and 3 test groups were given Japanese ant powder with a dose of 9 mg / kg bw (SJ 9), 45 mg / kg bw (SJ 45), and 90 mg / kg bw (SJ 90). Blood glucose levels were measured on the first day, day 3, day 7, and day 14. Results: The use of SJ 45 and SJ 90 were better in lower blood glucose compared to the glibenclamide comparison group. Conclusion: Japanese ant powder at doses of 45 and 90 mg / kg bw give an antidiabetic effect that is better than glibenklamid 5 mg / kg bw in reducing blood glucose levels in mice induced by alloxan. Keyword : Semut jepang powder, diabetes mellitus, blood glucose level
Co-Authors Andreanus A. Soemardji Asri Dwijayanti Dwijayanti, Asri Erwin Samsul Ferlin Wandasari Irda Fidrianny Komar Ruslan Wirasutisna Muhamad Insanu Nurma Sabila Rizka Mulya Miranti Samsul, Erwin Sukrasno Sukrasno Wandasari, Ferlin Wirasutisna, Komar Ruslan Wirasutisna, Komar Ruslan Yohanes Andika Suharli