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All Journal Medicina Buletin Udayana Mengabdi E-Jurnal Medika Udayana Jurnal Veteriner Majalah Ilmiah Fisioterapi Indonesia JURNAL BIOMEDIK E-Jurnal Udayana Medica Jurnal Kesehatan Andalas MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Jurnal Ners Bali Anatomy Journal Oryza : Jurnal Pendidikan Biologi eJournal Kedokteran Indonesia Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan

I Wayan Sugiritama

Departemen Histologi Fakultas Kedokteran Universitas Udayana

Author-ID : 388906

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Topical application of purple cabbage (Brassica oleracea L. var. capitata f. rubra) ethanol cream extract of dermic collagen on male Wistar rats (Rattus norvegicus) exposed to ultraviolet B Komang Jegek Triangga Apsari; I Gusti Ayu Dewi Ratnayanti; I Gusti Komang Nyoman Arijana; I Wayan Sugiritama
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Purple cabbage or also known as red cabbage (Brassica oleracea L. var. capitata f. rubra) contains polyphenols, especially anthocyanin (cyanidin-3-diglucoside-5-glucoside). Anthocyanin has a protective effect against radical oxidative superoxide (ROS). Thus it can prevent skin damage caused by ultraviolet (UV)-B radiation.Aim: The research aims to prove the effectivity of distribution of purple cabbage ethanol cream extract prevented the decrease of dermal collagens on Wistar rats (Rattus norvegicus) exposed to UV-B rays.Method: This research was arranged with the randomize post-test only control group design. 30 rats were divided into 6 groups containing 5 rats each, there are control group (P1) without distribution of any cream, Treatment Group (P2) with a distribution of base cream (placebo), (P3) sunblock 33 SPF, (P4) 5%, (P5) 10 %, and (P6) 20 % smeared by purple cabbage ethanol cream extract. All groups exposed to UV-B with a total dose of 840 mJ/cm2 for 4 weeks. Then a sampling rats skin was done for examining the level of collagen skin with Sirius red staining. The level of collagen was calculated by the percentage of the area of the pixel of collagen and was compared with the pixels of entire dermal tissues.Result: The result demonstrated that the mean of collagens in The First Group/P1 (57.74%) and P2 (60.84%) decreased more significantly than P3 (82.17%), P4 (68.23%), P5 (76.93%), and P6 (84.54%) following UV-B exposure. The Post Hoc result showed that there was no significant difference in the level of collagen in the control group and placebo group and the sunblock group with the purple cabbageâ€™s ethanol cream extract group of 20% (p>0.05).Conclusion: the distribution of purple cabbage ethanol cream extract prevented the decrease of dermal collagens on male Wistar rats skin exposed to UV-B.

Ethanolic extract cream of red cabbage (Brassica oleracea L. var. capitata f.rubra) on the epidermal thickness in Wistar rats (Rattus norvegicus) after ultraviolet-B exposure Yogarani V.C Rajappan; I Gusti Kamasan Arijana; I Wayan Sugiritama; IGA Dewi Ratnayanti
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Background: UV exposure is related to oxidative stress and also as an essential factor in skin photoaging. Several antioxidants are widely used in preventing skin photoaging by influencing epidermal skin layer. High concentrations of antioxidant properties in red cabbage are known to have these effects. This study aims to determine the role of ethanolic extract cream of red cabbage on the epidermal thickness in Wistar rats after UV-B exposure.Methods: An experimental study was carried out among 25 Wistar rats which divided into 5 groups as follows: P1 as control (only exposed to UB-B), P2 (placebo and UV-B), P3 (5% ethanolic extract cream and UV-B), P4 (10% ethanolic extract cream and UV-B), and P5 (20% ethanolic extract cream and UVB). The UV-B dosage applied for each group was 65 mJ/cm2. The thickness of epidermis is calculated by direct measurement using Image Raster software from basal membrane to stratum corneum. The statistical analyses were performed using SPSS ver. 20.0.Results: There was a significantly different in the epidermal thickness among groups (P < 0.05). The mean of epidermal thickness in the control group (P1) was 36.00Â±1.08 Âµm, followed by 27.66Â±0.87 Âµm in the treatment group I (P2), 26.76Â±1.02 Âµm in the treatment group II (P3), 24.94Â±1.25 Âµm in the treatment group III (P4), and 20.24Â±1.47 Âµm in the treatment group IV (P5).Conclusion: The ethanolic extract cream of red cabbage (Brassica oleracea L.Var. capitata f. rubra) in different doses have a statistically significant impact on the epidermal thickness in Wistar rats after UV-B exposure.

The ethanolic extract of red cabbage (Brassica oleracea l. var,capitata f. rubra) in cream preparation to the dermal-thickness of male Wistar mice (Rattus norvegicus) after Ultraviolet-B exposure Gayathiri Mohana Krishnan; IG Kamasan Arijana; I Wayan Sugiritama
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Background: Photoaging effect in dermal layer of skin was commonly caused by Ultraviolet B (UV-B) rays exposure This study aims to assess the histological features of the dermis layer in the male Wistar mice after applied with the ethanolic extract of red cabbage following UV-B exposure.Methods: About 25 male Wistar rats were enrolled in this study by using post-test only control group design during 2 weeks. They were divided into 5 groups as follows: control group (P1), basic cream (P2), 5% ethanolic extract of red cabbage cream (P3), 10% ethanolic extract of red cabbage cream (P4), and 20% ethanolic extract of red cabbage cream (P5). The UV-B dosage used are 325 mJ/cm2 among groups prior to study. The dermis-elastic fiber thickness was assessed by Image Raster software. Statistical analysis was carried out using SPSS version 20 in measuring normality test, mean, and ANOVAResults: There was no statistically significant difference in the thickness of dermal layer among groups (P = 0.3). The mean of dermis thickness was 666.60Â±143.15Âµm in P5 group, followed by 651.19Â±189.18Âµm in P4 group, and 547.43Â±188.41Âµm, 544.76Â±100.67Âµm, and 504.10Â±129.40 Âµm in P3, P2, and P1 group respectively.Conclusion: There was no a significant difference among different dosage of the ethanolic extract cream of red cabbage to the thickness of dermal layer after UV-B exposure.

The effect of red-cabbage (Brassica oleracea L. var. capitata f. rubra) ethanolic extract in cream preparation on dermis-elastic fibre thickness in male Wistar rats after ultraviolet-B rays exposure Intan Syahirah Bt Abdul Rauap; I Wayan Sugiritama; Ni Made Linawati; I Gusti Kamasan Arijana
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Background: Ultraviolet B (UV-B) rays exposure is a leading cause of sunburn, skin dryness and skin aging by influencing the dermal elastic fibers. This photoaging effect was caused by damage of fibrillin-1 as a microfibrillar network. This study aims to evaluate the effect of red-cabbage (Brassica oleracea L. var. capitata f. rubra) ethanolic extract in cream preparation on dermis-elastic fibers thickness in male Wistar rats after UV-B exposure.Methods: A randomized post-test only control group design was conducted among 25 male Wistar rats during 2 weeks. They were divided into 5 groups as follows: control group (P1), basic cream (P2), 5% ethanolic extract of red cabbage cream (P3), 10% ethanolic extract of red cabbage cream (P4), and 20% ethanolic extract of red cabbage cream (P5). The UV-B dosage used are 325 mJ/cm2 among groups prior to study. The dermis-elastic fiber thickness was assessed by Image Raster software. Statistical analysis was carried out using SPSS version 20 in measuring normality test, mean, and ANOVAResults: There was a statistically significant difference of dermal-elastic fibers thickness among groups (P < 0.05). The mean of dermis-elastic fiber thickness was 6.125Â±0.376 Âµm in P5 group, followed by 4.075Â±0.266 Âµm in P4 group, and 3.114Â±0.290 Âµm, 2.109Â±0.420 Âµm, and 1.907Â±0.454 Âµm in P3, P2, and P1 group respectively.Conclusion: Ethanolic extract of red-cabbage in a different dose of cream preparation have a statistically significant difference on the dermis-elastic fibers thickness after UV-B exposure

Pengaruh ekstrak kulit buah naga merah (Hylocereus polyrhizus) terhadap kadar malondialdehyde liver pada tikus yang diberi paparan asap rokok Melita Soares Cristovao; IGN Sri Wiryawan; I Wayan Sugiritama
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Peel of red dragon fruit (Hylocereus Polyrhizus) is rarely utilized which is usually just thrown away, even though it contains such high antioxidants such as phenols, flavonoids and also anthocyanins.Methods: This study aims to determine the effect of red dragon fruit skin extract (Hylocereus Polyrhizus) on MDA levels of the liver in rats exposed to cigarette smoke. This research is an experimental study with Post-Test Only Control Group Design. The sample consisted of 30 rats aged 3-4 months which were divided into 5 groups each amounting to 6 rats, namely 1 negative control group was not given exposure to cigarette smoke, 1 group of negative cock was exposed to cigarette smoke, 3 treatment groups were given exposure cigarette smoke and administration of red dragon fruit skin extract with doses of 20mg, 40mh, and 80mg for 14 days. The parameters measured were MDA levels of the liver.Results: mean liver MDA level of control group 1 was 3.14 Â± 0.15nmol / ml, mean control group 2 was 3.84 Â± 0.88 nmol / ml, mean treatment group 1 was 3.78 Â± 0.28nmol / ml, group treatment 2 was 3.37 Â± 0.69nmol / ml, and treatment group 3 was 3.05 Â± 0.50nmol / ml. Significance analysis with One Way ANOVA test shows that the value of F = 2.127 and the value of p = 0.107, where the value of p> 0.05Conclusion: There was no effect of red dragon fruit skin extract (Hylocereus Polyrhizus) on MDA levels in the liver exposed to cigarette smoke.Latar Belakang: Kulit buah naga merah (Hylocereus Polyrhizus) merupakan limbah yang sangat jarang dimanfatkaan, biasanya kulit buah naga merah hanya dibuang begitu saja, padalah mengandung antioksidan yang begitu tinggi seperti fenol, flavonoid dan juga antiosianin.Metode: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak kulit buah naga merah (Hylocereus Polyrhizus) terhadap kadar MDA liver pada tikus yang dipaparkan asap rokok. Penelitian ini merupakan penelitian eksperimental dengan Post-Test Only Control Group Design. Sampel terdiri dari 30 ekor tikus yang berumur 3-4 bulan yang dibagi menjadi 5 kelompok masing-masing berjumlah 6 ekor tikus, yaitu 1 kelompok kontrol negative tidak diberikan paparan asap rokok, 1 kelompok kontol negative diberikan paparan asap rokok, 3 kelompok perlakuan diberikan paparan asap rokok dan pemberian ekstrak kulit buah naga merah dengan dosis 20mg, 40mg dan 80mg selama 14 hari. Parameter yang diukur adalah kadar MDA liver.Â Hasil: rerata kadar MDA liver kelompok kontrol 1 adalah 3,14 Â± 0,15nmol/ml, rerata kelompok kontrol 2 adalah 3,84 Â± 0,88 nmol/ml, rerata kelompok perlakuan 1 adalah 3,78 Â± 0,28nmol/ml, kelompok perlakuan 2 adalah 3,37 Â± 0,69nmol/ml, dan kelompok perlakuan 3 adalah 3,05 Â± 0,50nmol/ml. Analisis kemaknaan dengan uji One Way Anova menunjukan bahwa nilai F= 2,127 dan nilai p= 0,107, dimana nilai p>0,05Simpulan: Tidak ada pengaruh ekstrak kulit buah naga merah (Hylocereus Polyrhizus) terhadap kadar MDA liver pada tikus yang dipaparkan asap rokok.

Pengaruh ekstrak kulit buah naga merah (Hylocereus polyrhizus) terhadap kadar malondialdehyde (MDA) Paru pada tikus yang diberi paparan asap rokok Raditya Pradipta; IGN Sri Wiryawan; I Wayan Sugiritama
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Peel of a red dragon fruit (Hylocereus Polyrhizus) is rarely utilized which is usually just thrown way, even though it contains such high antioxidants such as phenols, flavonoids and also anthocyanins.Methods: This study aims to determine the effect of red dragon fruit skin extract (Hylocereus Polyrhizus) on MDA levels of lung in rats exposed to cigarette smoke. This research is an experimental study with Post-Test Only Control Group Design. The sample consisted of 30 rats aged 2-3 months which were divided into 5 groups each amounting to 6 rats, namely 1 negative control group was not given exposure to cigarette smoke, 1 group of positive cock was exposed to cigarette smoke, 3 treatment groups were given exposure cigarette smoke and administration of red dragon fruit skin extract with doses of 20mg, 40mh and 80mg for 14 days. The parameters measured were MDA levels of the lung.Results: The mean MDA level of lung control group 1 was 0.146 Â± 0.02 nmol / ml, the mean of control group 2 was 0.166 Â± 0.01 nmol / ml, the mean of treatment group 1 was 0.168 Â± 0.03 nmol / ml, treatment group 2 was 0.153 Â± 0.02 nmol / ml, and treatment group 3 was 0.776 Â± 0.09 nmol / ml. The significance analysis with the One Way Anova test shows that the value of F = 1.34 and the value of p = 0.282, where the value of p> 0.05Conclusion: There was no significant difference between the control group and the treatment group or between treatment group 1, treatment 2 and treatment 3.Â Latar Belakang: Kulit buah naga merah (Hylocereus Polyrhizus) merupakan limbah yang sangat jarang dimanfaatkan, biasanya kulit buah naga merah hanya dibuang begitu saja, padalah mengandung antioksidan yang begitu tinggi seperti fenol, flavonoid dan juga antiosianin.Metode: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak kulit buah naga merah (Hylocereus Polyrhizus) terhadap kadar MDA paru pada tikus yang dipaparkan asap rokok. Penelitian ini merupakan penelitian eksperimental dengan Post-Test Only Control Group Design. Sampel terdiri dari 30 ekor tikus yang berumur 2-3 bulan yang dibagi menjadi 5 kelompok masing-masing berjumlah 6 ekor tikus, yaitu 1 kelompok kontrol negative tidak diberikan paparan asap rokok, 1 kelompok kontrol positif diberikan paparan asap rokok, 3 kelompok perlakuan diberikan paparan asap rokok dan pemberian ekstrak kulit buah naga merah dengan dosis 20mg, 40mg dan 80mg selama 14 hari. Parameter yang diukur adalah kadar MDA paru.Hasil: Rerata kadar MDA paru kelompok kontrol 1 adalah 0,146 Â± 0,02 nmol/ml, rerata kelompok kontrol 2 adalah 0,166 Â± 0,01 nmol/ml, rerata kelompok perlakuan 1 adalah 0,168 Â± 0,03 nmol/ml, kelompok perlakuan 2 adalah 0,153 Â± 0,02 nmol/ml, dan kelompok perlakuan 3 adalah 0,776 Â± 0,09 nmol/ml. Analisis kemaknaan dengan uji One Way Anova menunjukan bahwa nilai F= 1,34 dan nilai p= 0,282, dimana nilai p>0,05Simpulan: Tidak ada perbedaan yang bermakna antara kelompok kontrol dengan kelompok perlakuan maupun antara kelompok perlakuan 1, perlakuan 2 dan perlakuan 3.

Pengaruh ekstrak krim Morinda citrifolia terhadap jumlah fibroblas pada penyembuhan luka tikus Wistar Vania Lannisa Haestidyatami; I Wayan Sugiritama; Ni Made Linawati
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Introduction. Wound healing is a complex biological process involving four stages, i.e., hemostasis, inflammation, proliferation, and remodeling. In the proliferation phase, there is an increase in the number of fibroblas cells. Morinda citrifolia is a fruit that contains the antioxidant compound, Quercetin. These antioxidant properties are thought to be able to accelerate the process of wound healing through the process of modulating the oxidative process and improving skin microstructure. The relationship of Quercetin to fibroblas cells which plays an essential role in the proliferation phase is not yet fully known. This study was conducted to determine the effect of Morinda citrifolia extracts on the number of fibroblas cells during the process of wound healing in Wistar rats.Method. Experimental, post-test with control group study was conducted using 24 rats divided into four groups. In group I, rats were treated with incisions and given a Placebo cream, groups II, III and IV were given incisions and cream containing ethanol extract of Morinda citrifolia 5%, 10%, and 20% respectively. The number of fibroblass was calculated using the digital analysis method using Image Raster 3 Software. The number of fibroblas cells was calculated as the percentage of fibroblas cells seen in the field of view. Data analysis conducted with the One-Way ANOVA and Post-Hoc LSD test.Results. The control group had an average number of fibroblas cells 23.3% Â± 1.9%. The mean fibroblas cells in the intervention group with extracts of 5%, 10%, 20% were 27.6% Â± 6.7%, 38.3% Â± 8.8% and 22.3% Â± 2.7%, respectively. The ANOVA test results showed a significant difference in the number of fibroblass between treatment groups (p<0.001). Post-hoc LSD test shown that only the treatment group with 10% extract showed a difference in the average number of fibroblas cells compared to the other groups.Conclusion. The highest number of fibroblas cells was found in the treatment group with 10% extract.

The effect of Euphorbia milii tea and its combination with Propolis on number of glomeruli in M.tb-infected mice: a histopathology study Ruthirar Kalaichelvam; Ni Made Linawati; I Gusti Nyoman Sri Wiryawan; Gede Wirata; I Gusti Ayu Dewi Ratnayanti; I Wayan Sugiritama; Ida Ayu Ika Wahyuniari; I Gusti Kamasan Nyoman Arijana
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: The role of both Euphorbia milii and Propolis is to increase the effectiveness in pathological condition of the body part damaged, include renal function in maintaining the homeostasis. That combination into mice which are infected by Mycobacterium tuberculosis will change the total number of glomerulus in the kidney.Aim: The study aims to determine the effect of combination tea from Euphorbia milii and Propolis on the number of the glomerulus in mice infected by M. tb.Method: This study confirmed randomized post-test only control group design consisting of 24 mice divided into six groups (G1-G6). E. milli flowers are obtained from flower plantations, in Ketewel, Gianyar, Bali Province took in fresh and dark red sampling. M. tuberculosis used H37Rv strain (ATCC27294) grown on Middlebrook 7H9 liquid medium for two weeks.Result: It was found that Group 3 and Group 5 from the treatment group has the most significant average number of glomerulus which was 13, followed by Group 2 and Group 6 from the control group has the largest average number of glomerulus which was 12. The differences were not significant between groups with P = 0.463 (P <0.05).Conclusion: The Euphorbia milii tea and its combination with Propolis does not affect histological change on the total number of glomerulus in mice infected with M. tb.

Prevalence of risk factors associated with hypertension at Sanglah General Hospital, Bali Mahen Isaac Pannir Chelvam; I Wayan Sugiritama; I Gusti Nyoman Kamasan Arijana
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: High blood pressure, also called "hypertension," is a serious medical condition. It happens when the force of the blood pumping through the arteries is too strong. The World Health Organization rates hypertension as one of the most important causes of premature death worldwide, and the problem is growing. This study aimed to determine the risk factors affecting Hypertension at Sanglah general hospital.Methods: This study was a descriptive study with a cross-sectional approach. The data used in this study is a secondary data collected from medical record of the patients with Hypertension at Sanglah general hospital, Denpasar, Bali in the year of 2015 until 2016. The data was categorized based on Body Mass Index (BMI), gender, age, alcohol consumption, and history of cardiovascular diseases.Results: There are 73(60.83%) males and 47(39.17%) females, the majority of patients were in the age group of 18 â€“ 70 years of age with the age group of 40 - 50 carrying a rather large quantity of 45.8% among the male gender and for the female gender the age group of 51 â€“ 60 showed the highest percentage of 38.2%, the sample consists of 60.83% of males and 39.17 of females from the total 120 samples taken from Sanglah general hospital. As for Body Mass Index (BMI), 25 â€“ 29.9 has the most significant value of 49 (40.83%) when compared to the other nutritional statuses present. The patients with the cardiovascular disease showed a very substantial amount of 69 (57.5%) among males and 41 (34.17%) among females. Patients with a history of alcohol consumption for the male gender had a value of 34 (28.30%), and for the female gender group, it carried an amount of 2 (1.70%).Conclusions: This study succeeded in identifying 120 samples of patients with hypertension and their contributing risk factors. The majority of the Samples were with body mass index (BMI) 25 â€“ 29.9 (40.83%). The samples with a history of cardiovascular disease showed a value of 69 (57.5%) among males and 41 (34.17%) among females. Patients with a history of alcohol consumption for the male gender had a value of 34 (28.30%), and for the female gender group, it carried an amount of 2 (1.70%)

Pemberian ekstrak kulit buah anggur (Vitis vinifera L.) mampu menurunkan kadar malondialdehid (MDA) plasma pada tikus dengan diet tinggi kolesterol Etik Nurhidayati; Ni Made Linawati; I Wayan Sugiritama
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Introduction: High cholesterol levels will cause disease, one of which is cardiovascular disorders or diseases. Based on WHO data in 2012 there were 17.5 million deaths in the world due to cardiovascular disease. Coronary heart occupies the highest position at 42% where one of the most common risk factors is dyslipidemia. This research aimed to evaluate the effect of grape skin extract on plasma MDA level.Methods: This study is an experimental study with a post-test only control group research design. Thirty male Wistar rats aged 2-3 months with a body weight of around 200 grams and healthy, classified into 4 treatment groups and a control group with a high cholesterol diet and administration of different dosages of grape skin extract, dose of 100 mg/175 gbw (gram body weight), 250 mg/175 gbw, and 500 mg/175 gbw. All blood samples were taken on day 30 and an MDA test was performed. Kruskal Wallis test was performed to analyze the correlation.Results: The test results obtained with p<0.05 in the group of rats given grape skin extract at a dose of 100 mg/175 gbw, 250 mg/175 gbw, and 500 mg/175 gbw, thus showing significantly lower MDA levels compared with control group.Conclusion: Administration of grape skin extract to rats given a high cholesterol diet may reduce plasma MDA levels.Â Latar belakang: Kolesterol yang tinggi di dalam darah akan mengakibatkan berbagai masalah kesehatan, salah satunya adalah gangguan atau penyakit kardiovaskular. Data tahun 2012 terdapat 17,5 juta kematian di dunia karena masalah kardiovaskular. Jantung koroner menduduki posisi tertinggi yaitu 42% dimana salah satu faktor risiko terseringnya adalah dislipidemia. Mengetahui dampak pemberian kulit buah anggur terhadap MDA plasma tikus adalah sasaran penelitian ini.Metode: Sebuah penelitian eksperimental menggunakan metode post-test only diterapkan pada penelitian ini. Tiga puluh tikus wistar jantan, umur 2-3 bulan, berat rerata 200 gram, dan sehat, dikelompokkan ke dalam 1 kelompok kontrol serta 4 kelompok perlakuan dengan diet tinggi kolesterol dan pemberian dosis ekstrak kulit anggur yang berbeda-beda, yaitu dosis 100 mg/175 gbb, 250 mg/175 gbb dan 500 mg/175 gbb. Pada akhir penelitian, yaitu hari ke- 30, semua sampel diambil darahnya kemudian dilakukan uji MDA.Hasil: Uji penelitian dengan Kruskal Wallis memperoleh hasil p=0,035 (p<0,05) pada kelompok tikus yang diberikan ekstrak kulit anggur dengan dosis 100 mg/175 gbb, 250 mg/175 gbb dan 500 mg/175 gbb, sehingga menunjukkan kadar MDA lebih rendah signifikan dibanding dengan kontrol.Simpulan: Pemberian ekstrak kulit buah anggur memiliki dampak penurunan MDA plasma pada tikus dengan diet tinggi kolesterol.

Co-Authors Agus Eka Darwinata Alifia Dwi Lestari Anak Agung Gede Eka Septian Utama Arcana N Ari Wibawa Ari Wibawa Aria Wibawa Arijana, I G Kamasan Nyoman Arijana, I Gusti Nyoman Kamasan Arijana, IGK Nyoman Bella Aulya Safitri Desak Ketut Ernawati Desak Putu Citra Udiyani Dewa Ayu Agus Sri Laksmi Dewi, Anak Ayu Nyoman Trisna Narta Dewi, Ni Made Gita Kusuma Dyta Putri Aryo Eswariy Chandramogan Etik Nurhidayati Eugenia Meidy Fedik Abdul Ratam Ferbian M. Siswanto, Ferbian M. Fitrotul Imaniyah Gabrielle, Gabrielle Gayathiri Mohana Krishnan Gede Parta Kinandana Gede Wirata Gusti Ngurah Mayun Hernowo, Elliana Freya I Dewa Ayu Eka Widiari Putri I Dewa Ayu Inten Primayanti I Dewa Gede Angga Triadi Nata I Gde Haryo Ganesha I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dwita Wahyu Laksmi I Gusti Kamasan I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Gusti Nyoman Sri Wiryawan I Made Jawi I Made Krisna Dinata I MADE MULIARTA . I Made Niko Winaya I Made Sudarmaja I Nyoman Adi Putra I Nyoman Gede Wardana I Nyoman Wande I Putu Adi Merta I Putu Adiartha Griadhi I Putu Bayu Mayura, I Putu Bayu I Putu Dema Prasetya I Wayan Juli Sumadi I. G. A. D. Ratnayanthi Ida Ayu Dewi Wiryanthini Ida Ayu Ika Wahyuniari IGN Iswarabhuwana WP Indira Vidiari Juhanna Intan Syahirah Bt Abdul Rauap Jessica Yuwono Joshua Ezra Ronaldo Bayak Kadek Ady Antara Kenjiro, Eduardo Komang Dhyanayuda P. Komang Jegek Triangga Apsari Linawati N.M Linawati, Ni M. Linawati, NM Luh Putu Ratna Sundari M Widnyana Made Dwi Indah Permatahati Gita Made Hendra Satria Nugraha Made Tami Budirejeki Mahen Isaac Pannir Chelvam Masnathasari, NM Ayu Maulidya, Maulidya Mayun G.N Melita Soares Cristovao N. M. Linawati Negara, Anak Agung Gede Angga Puspa Ni Kadek Mira Wirayani Ni Komang Tristiana Dewi Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Luh Nopi Andayani Ni Luh Nopi Andayani, Ni Luh Nopi Ni Made Deni Purnama Ni Made Linawati Ni Made Mertaniasih Ni Made Rininta Adi Putri Ni Nyoman Mekar Sari Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Ni Putu Junika Putri Ni Putu Sriwidyani Nila Wahyuni Norshazreen Nazri Nuril Hidayah Pangkahila, Elionardo Putra, I Putu Yudi Pramana Putri Miucin Raditya Pradipta Rahcmanita, Dhila Cahya Rastika, I Gede Agus Ratnayanthi, I Gusti Ayu Dewi Ratnayanti, Gusti Ayu Dewi Regina, Ni Kadek Pramesti Ruthirar Kalaichelvam Santoso, Natania Faustine Saraswati, Ni Luh Putu Gita Karunia Saraswati, Putu Ayu Sita Susilo, Yunike Trisna Damayanti Vania Lannisa Haestidyatami Widianti, I Gusti Ayu Widianti, IGA Wona, Yohana Virani Wong, Ferdinand Yogarani V.C Rajappan Zahra, Fahdia Fitrianti

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