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All Journal BERITA BIOLOGI Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology JSFK (Jurnal Sains Farmasi & Klinis) Annales Bogorienses
LINDA SUKMARINI
Research Center for Biotechnology, Indonesian Institute of Sciences (LIPI), Jl. Raya Bogor Km. 46 Cibinong 16911 Bogor.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : JSFK (Jurnal Sains Farmasi

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Metabolomic and Cytotoxicity Profiles of Ethanol Extract of Peronema canescens Jack on Human Non-small Lung Cancer Cell A549 Anjayani, Nuri; Amalia, Senya Putri; Sukmarini, Linda; Tamhid, Hady Anshory; Primahana, Gian; Triastuti, Asih
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.7-14.2025

Abstract

Cancer has a high prevalence and mortality in the world. Cancer treatment is still hampered by high levels of side effects, drug resistance and the lack of affordable prices for anticancer drugs. It is necessary to develop new anticancer drugs to help overcome this problem. One of the plants that has the potential to be developed as an anticancer drug is Sungkai (Peronema canescens Jack). This study aims to determine the cytotoxic activity of sungkai leaf and identify its metabolomic profile. The sungkai leaves were macerated for 24 hours with 96% ethanol. Metabolomic profiles were analyzed with Ultra High-Performance Liquid Chromatography-High Resolution Mass Spectrometry (UHPLC-HRMS). Chemical structure identification was performed by MS-DIAL and MS-FINDER platforms. The ethanol extract of sungkai leaves was analyzed for its cytotoxic activity using the MTT test on A549 lung cancer cells and its selectivity on normal HDFa fibroblast cells. The ethanol extract of sungkai showed IC50 105,21 µg/mL on A549 cells and no cytotoxic activity against normal HDFa cells. Based on the metabolomic analysis, 7 furano terpenoid compounds were detected in the ethanol extract, namely peronemin A2; A3; B1; B2; B3: C1; and D1 along with other compounds. In conclusion, the ethanol extract of P. canescens leaves has cytotoxic and selective activity against A549 lung cancer cells, and potential to be further developed as an anticancer drug candidate. Peronemins and other substances like flavonoids and polyphenols may be linked to the cytotoxic properties of sungkai leaves
Co-Authors Adi Santoso Amalia, Senya Putri Anjayani, Nuri Apon Zaenal Mustopa Asih Triastuti Atikana, Akhirta Desriani Desriani Dwi Wulandari Hasim - Kusharyoto, Wien Maulidia, Faiqoh Nur Neng Herawati, Neng Ni Luh Putu Vidya Paramita Prasetyoputri, Anggia Prayoga, Muhammad Bagas Primahana, Gian PUSPITA LISDIYANTI Putra, Masteria Yunovilsa Putri, Andini Setyanti Rifqiyah Nur Umami, Rifqiyah Nur Riyona Desvy Pratiwi, Riyona Desvy SHANTI RATNAKOMALA Tamhid, Hady Anshory Titik Nuryastuti Triana Hertiani Untari, Febriana Wibowo, Krisna Dwi Aria Yana Rubiyana, Yana