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All Journal PHARMACON Pharmaciana: Jurnal Kefarmasian BAHASA DAN SASTRA Jurnal Farmasi Klinik Indonesia English Review: Journal of English Education Syntax Literate: Jurnal Ilmiah Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JELL (Journal of English Language and Literature) STIBA-IEC Jakarta Silampari Bisa: Jurnal Penelitian Pendidikan Bahasa Indonesia, Daerah, dan Asing Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ JTP - Jurnal Teknologi Pendidikan Jurnal Teknik JURNAL FARMASI GALENIKA Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Dinamika UMT Lingua Rima: Jurnal Pendidikan Bahasa dan Sastra Indonesia Jurnal Insan Farmasi Indonesia Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Locus Penelitian dan Pengabdian Jurnal Talenta Sipil Jurnal Pembelajaran Sastra The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Jurnal Farmasi Indonesia Edukasi Masyarakat Sehat Sejahtera (EMaSS) Guruku: Jurnal Pendidikan dan Sosial Humaniora Jurnal Sadewa: Publikasi Ilmu Pendidikan, Pembelajaran dan Ilmu Sosial Jurnal Gizi dan Dietetik Jurnal Medika Farmaka Inaba of Community Services Journal The Indonesian Journal of Computer Science Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat Jurnal Teknik Sipil Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Agus Sulaeman
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Journal : Jurnal Farmasi Indonesia

 1 
Efek Pemberian Ekstrak Etanol Bunga Rosella (Hibiscus sabdariffa L.) terhadap Inflamasi dan Disfungsi Endotel Kaniawati, Marita; Sulaeman, Agus; Nurfazri, Aulia; Susilawati, Elis; Auliyaa, Millata; Maia de Fatima Freitas, Floriana
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 1 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i1.238

Abstract

Obesitas dapat menyebabkan terjadinya pembesaran dan penambahan jumlah sel adiposa dalam tubuh serta penurunan kadar adiponektin. Adiponektin merupakan salah satu sitokin antiinflamasi. Obesitas juga berhubungan dengan disfungsi endotel vaskular, yang disebabkan oleh berkurangnya ketersediaan nitrit oksida (NO), sebagai akibat dari adanya peningkatan produksi stress oksidatif. Penelitian ini bertujuan untuk mengetahui pengaruh dari ekstrak etanol bunga rosella (Hibiscus sabdariffa Linn) terhadap kadar adiponektin dan kadar NO serum pada model hewan obes yang diinduksi fruktosa. Metode penelitian disusun dengan Post Test Only Control Group Design menggunakan hewan uji tikus jantan Galur Wistar selama 60 hari. Penelitian ini menggunakan 6 kelompok perlakuan yaitu kelompok normal (diet normal), kelompok induksi (diet normal + fruktosa 60%), kelompok pembanding (diet normal + fruktosa 60% + orlistat), dan 3 kelompok uji (diet normal + fruktosa 60% + esktrak etanol bunga rosella 125 mg/kgBB, 250 mg/kgBB dan 500 mg/kgBB). Hasil penelitian menunjukkan bahwa ekstrak etanol bunga rosella memiliki efek menurunkan bobot badan dan meningkatkan kadar adiponektin dan NO serum. Sebagai kesimpulan ekstrak etanol bunga rosella dengan dosis 250 mg/kgBB dapat meningkatkan kadar adiponektin dan dosis 500 mg/kgBB merupakan dosis terbaik dalam memperbaiki disfungsi endotel.
Aktivitas Antidislipidemia Rebusan Daun Mangga Kultivar Manalagi (Mangifera indica L. Var. Manalagi) Sulaeman, Agus; Susilawati, Elis; Aolina, Shelin
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1046.04 KB) | DOI: 10.35617/jfionline.v14i2.104

Abstract

Abstract: Dyslipidemia is characterized by changes in lipid levels in plasma, a common indicator that is prone to the risk of cardiovascular disease. Plants that are suspected to have antidislipidemia activity, one of which is mango leaves. This study aimed to determine the effective dose in a decoction of mango manalagi leaves (Mangifera indica L. var. Manalagi) in decreasing levels of total cholesterol, triglycerides, LDL, and increasing HDL levels in high-fat feed-induced rats and propylthiouracil for 28 days. This research method was carried out preventively using 30 Wistar strain male rats which were grouped into 6 groups, namely negative control, positive control, comparison control (simvastatin 1.8mg/Kg BW), and a decoction test of manalagi mango leaves at a dose of 200, 400, 800 mg/kg BW. The parameters of the observed lipid profile are determined enzymatically using the micro lab. The results of the study on total cholesterol levels, showed the largest decreasing in the 200mg/kg BW dose group by 31.29%, in triglyceride levels the largest decreasing was found in the 400mg/kg BW dose group by 40.59%, in LDL levels the largest decreasing was found in the 200 mg/kg BW dose group by 48.03%, and in HDL levels there was the largest increasing in dose 800mg /kg BW of 97.40%. This study concludes that manalagi mango leaf decoction can be an antidyslipidemia in decreasing total cholesterol, triglyceride, and LDL levels as well as increasing HDL levels, with an effective dose of 200mg/ kg BW.
Potensi Penghambatan Enzim Αlfa-Glukosidase dan Tes Toleransi Glukosa Oral (TTGO) Ektrak Daun Dadap Serep (Erythrina subumbrans (Hassk) Merr.): Susilawati, Elis; Astuti, Ayu Dwi; Sulaeman, Agus
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.773 KB) | DOI: 10.35617/jfionline.v15i1.135

Abstract

Abstract: Spare dadap plants contain flavonoids that can potentially lower glucose levels in the blood and reduce glucose absorption in the intestine. The purpose of the study was to determine the inhibitory activity of the α-glucosidase enzyme and the effect of giving Spare Dadap Leaf Ethanol Extract (EEDDS) on blood glucose levels of male white Wistar rats and its effective dose. The research method used the in vitro method with inhibition of α-glucosidase enzyme and the in vivo method Glucose Tolerance Test (TTGO) with amylum manihot induction using 25 rats divided into 5 groups with EEDDS doses of 100, 200, and 400 mg / kg BB, then measured blood glucose levels for 120 minutes. The results of the EEDDS α-glucosidase enzyme inhibition study showed the best % inhibition value of 41.81% at 100 ppm and the lowest % inhibition value at 10 ppm, which was 13.33% with an IC50 value of 146.30 ppm, which was included in the weak category in inhibiting α-glucosidase. The results of TTGO research induced amylum manihot, EEDDS 400 mg / KgBW have a significant effect on reducing blood glucose levels in the T60 to T120 range. The conclusion in this study is that spare dadap leaf ethanol extract has potential as an antihyperglycemic both in vitro and in vivo.
Co-Authors Adinda, Deistha Adzkia, Muhammad Fasya Ahmad Suherman Akbar Rulazi, Bagus Ali Sulaiman Ali Sulaiman Anne Yuliantini Aolina, Shelin Ardadinata, Raihan Arief, Mansur Ariyana Ariyana Ariyana, Ariyana Asherlia, Dwita Astuti, Ayu Dwi Aulia Nurfazri Istiqomah Aulia, Arsy Auliyaa, Millata Azhari, Swary Anistri Bachrudin, Panji Bayinah, Ai Nur Deni Iskandar Destianto, Anto Dewi, Nova Freena Dhiani, Yanni Dimas R. Pambudi Djoko Widodo Dwitantika, Bryan Eka Cahyani, Dhiana Eka Gumilang, Nurani Eka Wardatul Jannah eko putra, eko Embas Saraswati, Dewa Ayu Enawar, Enawar Ernawati Ernawati Fatmawati, Eva Fauziyah, Azkia Nurul Fauziyah, Roro Nur Garnadi Jafar, Garnadi Gatot Susilo Lawrence Ghassani, R Wulandari Goziyah Goziyah Goziyah, Goziyah gumilar, mulus Hanna Sundari Hapsari , Agustina Indri Haryanti, Reni Hasimun, Patonah Hastuti, Widi Heny Sulistyowati Herdiansah , Yudi Herdiansah, Yudi Hoon, Kim Dong Hossanti Ntobu, Febri Hun, Kim Dong Idar Ira Miranti, Ira Irawan, Farid Irman, Deni Irviansyah, Cepy Okta Isybillah Ahmad, Afifah Judiono Judiono Juli Yani Kamiri, Kamiri Larson Boling Sau, Barth Lindasari, Heni Lutfiyah, Fifih M Ramadhan Saputro Maia de Fatima Freitas, Floriana Malik Al Akbar, Ayatullah Mamat Rahmat Marita Kaniawati Marliani, Lia Maryati Dewi, Maryati Maulana, Didit Mia N. A. Fatin Mona Fitria Muhamad Agung Muhamad Iqbal mulus gumilar Mutoharoh Mutoharoh Nori Anggraini, Nori Novia Adiningsih, Arum Nurfadillah, Ilham Nurfazri Istiqomah, Aulia Nurfazri, Aulia Nurjaman, Jajang Patonah Prasasti, Tresna Dewi Purawinangun, Ira Anisa Pusparini Pusparini Putra, Hendra Mahakam Rafiansyah, Rafli Rizki Rahmat Santoso, Rahmat Rahmatullah, Muhammad Firdaus Rauda Ramdania, Diena Regi Fasya Septrian Resdiana, Rafli Aridzalrahman Reza Pratama Rizkyanto, Dheva Ferdinand Rofi’i, Agus Roni Farfian Roni Hidayat Rosmana, Dadang Rossa Rosefa Simanjuntak Royani, Ani Rum, Ira Adiyati Saleky, Yohannes Willihelm Salma Tia Salsabila Saputra, Nanda Saputro, M. Ramadhan SARI APRIYANI Sayeti, Ety Siti Supriyati Stiani, Sofi Nurmay Sumarjo, Dwi Nur Ida Islamiati Suri Darmawan, Ammar Susilawati, Elis Syaharuddin Kasim Syahrizal Syahrizal Syarifuddin Wahid Syarifuddin Wahid Tundreng, Syarifuddin Udayanto, Nugroho Sungkono Vallini, Lia Wati, Afifah Ashma Widartika Widartika Widianto, Asriadi Prihandika Winara, Zahra Winasari, Winasari Winda Dwihudhana Witri Priawantiputri Xbal Meiprasetyo Yani Mulyani Yayuk Febriyanthi , Anggita Yenny Moviana, Yenny Yermia Ademi Dedeo Yuliani, Rany Yunita, Dilla Zinan, Daula Zahra