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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Jurnal Sistem Kesehatan Indonesian Journal of Rheumatology Pharmacology and Clinical Pharmacy Research Ina Kidney Indonesian Journal of Global Health research The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal MedScientiae Jurnal MedScientiae
Rudi Supriyadi
Division Of Nephrology And Hypertension, Department Of Internal Medicine, Faculty Of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Indonesian Journal of Global Health research

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Nutriepigenetic Modulation of Hypertension Risk: A Review of the Literature Iryaningrum, Maria Riastuti; Soetedjo, Nanny Natalia Mulyani; Indraswari, Noormarina; Supriyadi, Rudi
Indonesian Journal of Global Health Research Vol 7 No 2 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i2.4774

Abstract

This review aimed to investigate the interplay between dietary components and epigenetic modulation in the pathogenesis of hypertension. A comprehensive literature search encompassing all published primary and secondary research dating up to March 2024 was carried out on several electronic databases, including MEDLINE, EBSCO-Host, Science Direct, ProQuest, and Google Scholar. Individual genomes and dietary intake exhibit a bidirectional relationship, influencing the hypertension risk. Unhealthy dietary patterns can compromise DNA integrity through DNA methylation and histone acetylation, ultimately affecting both systolic and diastolic blood pressure. Dietary macronutrient composition (carbohydrates, lipids, and proteins) significantly alters the expression of specific microRNAs (miRNAs) known to regulate endothelial function and blood pressure homeostasis. Moreover, micronutrients (vitamin A, D, E, Zinc, Iodine, and Sodium) can exert epigenetic effects on blood pressure via receptor interactions, potentially modifying cardiovascular disease risk. Dietary imbalances in macro and micronutrients can epigenetically influence hypertension development. Addressing these deficiencies through targeted interventions may offer a complementary approach to hypertension treatment.
Co-Authors . SETIAWAN AJENG DIANTINI Ajeng Diantini, Ajeng Anthoni Anthoni Arto Y. Soeroto Bayu Laksono Budhi Prihartanto Christine Elizabeth Suryajaya David Kristianus David Paranoan Davin Takaryanto Davin Takaryanto Gaga Irawan Nugraha Herri S. Sastramihardja Hikmat Permana Hikmat Permana Ibrahim, Susannia Ivena Ivena Kartika Malahayati Kusumawati, Maya Laniyati Hamijoyo Laurensia Imelda Lazuardhi Dwipa Liza Karina Hauteas Lukman Pura Malahayati, Kartika Maria Riastuti Iryaningrum Muhammad Begawan Bestari Nanny N. M. Soetedjo Nanny N. M. Soetedjo Nanny Natalia Mulyani Soetedjo Nenny Agustanti Nenny Agustanti Nida Dwi Nafisah Nida Suraya Nida Suraya Noormarina Indraswari Nuraini Yasmin Kusumawardhani Rachmat Soelaeman Rakhima, Fauliza Ria Bandiara Ritonga, Ervita Rizka Putri Hamuktiono Rizka Putri Hamuktiono, Rizka Putri Siska Wiramihardja, Siska Siti Aminah Abdurachman Siti Nur Fatimah Susannia Ibrahim Susantina Prodjosoewojo Yenni Zuhairini Yenni Zuhairini Yulia Sofiatin