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Journal : Berkala Ilmu Kesehatan Kulit dan Kelamin

Terapi Cairan dan Elektrolit pada Keadaan Gawat Darurat Penyakit Kulit Oki Suwarsa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 2 (2018): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (19.456 KB) | DOI: 10.20473/bikk.V30.2.2018.162-170

Abstract

Latar Belakang: Kulit berfungi untuk melindungi tubuh dari kehilangan cairan dan elektrolit berlebihan. Pada penyakit nekrolisis epidermal toksik, sindrom Stevens-Johnson, Staphylococcal scalded skin syndrome, dan pemfigus vulgaris terjadi kegawatdaruratan disebabkan oleh terbentuknya bula yang luas, sehingga cairan hilang berlebihan melalui kulit. Tujuan: Terapi cairan dan elektrolit intravena bertujuan mengganti kekurangan air, elektrolit, dan zat makanan yang diperlukan tubuh. Telaah Kepustakaan: Pemberian cairan dan elektrolit harus berdasarkan penyebab, kemudian menentukan jenis, jumlah, serta kecepatan pemberian. Penatalaksanaan meliputi evaluasi status hemodinamik, memeriksa kadar elektrolit, analisis gas darah, memasang tekanan vena sentral, dan kateter urine untuk menghitung kehilangan cairan sehingga dapat diberikan cairan dan elektrolit yang tepat. Terapi suportif pada kegawatdaruratan penyakit kulit sama dengan pasien luka bakar, yaitu menggunakan ‘rule of nine’ untuk bula >10% total area permukaan tubuh.Cairan yang dianjurkan adalah NaCl 0,9%, Ringer laktat, dan dextrosa 5%.Simpulan: Prognosis terapi cairan dan elektrolit pada keadaan gawat darurat penyakit kulit tergantung terapi yang adekuat, kelengkapan unit luka bakar, pemberian cairan yang tepat, dan nutrisi tambahan.
The Positive Skin Prick Test not Correlate with Disease Severity and Quality of Life in Atopic Dermatitis Patients Oki Suwarsa; Erfina Rohana Sormin; Endang Sutedja; Hartati Purbo Dharmaji
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (385.549 KB) | DOI: 10.20473/bikk.V29.3.2017.229-233

Abstract

Background: Atopic dermatitis (AD) is a skin disease which cause stress to the patients. The chronic process of AD can cause physical, social, and psychological impairments. The severity of AD can also be affected by allergen exposures, which in turn will affect the quality of life of the patient. Skin prick test (SPT) can be used to evaluate allergen sensitization. Purpose: To evaluate correlation between SPT positivity to severity and quality of life of AD patients. Methods: The study was an observational cross-sectional study. Twenty five AD patients were recruited based on inclusion and exclusion criteria. Questionnaire was used to measure the quality of life of patients, and Scoring of Atopic Dermatitis (SCORAD) to measure the disease severity. Most of participants were women (80%), with median of age 26.84±13.71. Results: Positive SPT was obtained in 68% of patients, most of them were caused by house dust mites (55.2%). Seventy six percent of patients experienced mild AD, 12% moderate AD, and also 12% patients experienced severe AD. Significant correlation was observed between the severity and quality of life (p=0.001;r=0.617), while the SPT positivity has no correlation with the severity (p=0.912;r=-0.023) and quality of life (p=0.959;r=0.011). Conclusion: This study revealed that the severity of the disease has a correlation with quality of life, but SPT positivity has no significant correlation with severity and quality of life.
The Effect of Systemic Methotrexate and Cyclosporine Combination Therapy inPsoriasis Vulgaris Patients in Bandung, Indonesia Oki Suwarsa; Fatima Aulia Khairani; Syawalika Ulya Isneny; Erda Avriyanti; Hartati Purbo Dharmadji; Miranti Pangastuti; Endang Sutedja; Hendra Gunawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 3 (2021): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.3.2021.200-204

Abstract

Background: Methotrexate (MTX) and cyclosporine have been used as effective systemic mono-therapy for psoriasis. Several factors are considered to switch monotherapy to combination therapy because monotherapy is no longer effective and has higher side effects. Hence,clinicians have avoided systemic therapy combinations due to its toxicity. However, some studies showed that this combination therapy could be usedeffectively for psoriasis patients. Purpose: This study aimed to analyze the efficacy and adverse effects of systemic MTX and cyclosporine combination therapy in Indonesian psoriasis vulgaris patients. Methods: The retrospective study assessed the effectiveness of 3 monthsmono-therapyand combination therapy of systemic MTX and cyclosporine in psoriasisvulgaris patients from 2016–2017 in Dermatology Clinic, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia. Result: Psoriasis area and severity index (PASI) score 90 were achieved in the group MTX (50%) and cyclosporine group (50%), while none in the combination group.However, eight patients (50%) in group MTX and cyclosporine reached the primary endpoint of PASI 50. One patient in cyclosporine group had adverse effects on kidney profiles. Nonetheless, other patients had no biochemical changes. But, there was no significant difference in the change of PASI between each group (p=0.102). Conclusion: We propose that combination therapy of MTX and cyclosporine is relatively safe and efficacious in treating Indonesian psoriasis vulgaris patients. This combination treatment isas effective as MTX or cyclosporinemono-therapy.
Co-Authors - Sudigdoadi, - Achadiyani Achmad Yudha Pranata, Achmad Yudha Achmad, Fariz Andrew Citrawan Dany Hilmanto Deborah, Anita Dedi Rachmadi Sjambas Devi Nursjamsi, Nadilla Carissa Dian Indriyani Dida Akhmad Gurnida Dida Akhmad Gurnida Dimas Erlangga Effendi, Rendy Ariezal Endang Sutedja Endang Sutedja Endang Sutedja Endang Sutedja Endang Sutedja Erda Avriyanti Erfina Rohana Sormin Eva Sri Rahayu Farid Husin Fatima Aulia Khairani Fenny Dwiyatnaningrum Fenny Dwiyatnaningrum, Fenny Feriza, Vina Firman Fuad Wirakusumah Gaga Irawan Nugraha Hadi Susiarno Hadi Susiarno Hartati Purbo Dharmadji Hartati Purbo Dharmadji Hartati Purbo Dharmadji, Hartati Purbo Hartati Purbo Dharmaji Hartati Purbo Dharmaji, Hartati Purbo Hendra Gunawan Insi Farisa Desy Arya Intan Karlina Irna Sufiawati Jayawarsa, A.A. Ketut Karinna Dwi Purnama Keni Istasaputri M. Lasiyati Yuswo Yani Maryam Nissa Hazari Maulinda, Shinta Metha Solihati Rayuna Miranti Pangastuti Muhammad Akbar Wicaksana Nanan Nur'aeny Nizami Hamada Nur Atik Nur'aeny, Nanan Nurwinda Saputri Pangastuti, Miranti Pati Aji Achdiat Ponpon Idjradinata Pratiwi, Auria Ekanti Purnama, Karinna Dwi Puteri Nabilah Maharani Raden Mohamad Rendy Ariezal Effendi Raden Tina Dewi Judistiani Rasmia Rowawi Reiva Farah Dwiyana Reti Hindritiani Riri Aprianti Ronny Lesmana Ruchiatan, Kartika Saputri, Nurwinda Siti Nurjanah Sjambas, Dedi Rachmadi Sri Mulyati Sudigdo Adi Sudigdo Adi Sunarjati Sudigdoadi Sunaryati S. Adi Susantina Prodjosoewojo Susiarno, Hadi Syawalika Ulya Isneny Tenny Putri Tiara Rica Dayani Uni Gamayani Vita Murniati Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Wicaksana, Muhammad Akbar Yogi Faldian Yuli Kurniawati Yuni Susanti Pratiwi