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All Journal Jurnal Veteriner Jurnal Biosains Pascasarjana Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Kedokteran dan Kesehatan JAIM (Jurnal Abdi Masyarakat)
Elfred Rinaldo Kasimo
Fakultas Ilmu Kesehatan Universitas Kadiri
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Ilmiah Universitas Batanghari Jambi

 1 
Uji Potensi Epigallocatechin Gallate Kulit Pisang Raja (Musa paradisiaca var. Raja) terhadap Caspase 3 melalui Granzyme B Pathway pada Mencit (Mus musculus) Model Sepsis Berbasis in Silico Lisa Savitri; Elfred Rinaldo Kasimo; Lian Pandu Farendra; Iza Dwi Muslikha
Jurnal Ilmiah Universitas Batanghari Jambi Vol 20, No 3 (2020): Oktober
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v20i3.1023

Abstract

Yellow ripe banana skin is rich in flavonoid compounds, and contains other phenolic compounds. The presence of flavonoids and other phenolic compounds in banana peels needs to be identified and tested for their activities, so as to increase the utilization of banana waste more optimally. Besides bananas also contain high epigallocatechin gallate (EGCG). EGCG is well known for its wide spectrum of biological activity as an anti-oxidative, anti-inflammatory and anti-tumor agent. The purpose of this study was to determine the potential of EGCG of plantain (Musa paradisiaca var. Raja) peel against caspase 3 through granzyme B pathway in mice (Mus musculus) sepsis model based on silico. Analysis of the potential of EGCG on mice was carried out using the application http://stitch.embl.de/. STITCH is a database of known and predicted interactions between chemicals and proteins. Interactions include direct (physical) and indirect (functional) associations, STITCH data derived from computational predictions, from the transfer of knowledge between organisms, and from interactions collected from other (primary) databases. Analysis of the mechanism of epigallocatechin gallate of plantain peel against capase 3 in sepsis mice using bioinformatics application https://www.kegg.jp/. Based on the results of the analysis it can be seen that EGCG can be used as a promising target agent candidate for plasma membrane proteins, such as epidermal growth factor receptors. In addition, action mechanisms have been demonstrated that rely on inhibition of ERK1 / 2, p38 MAPK, NF-κB, and vascular endothelial growth factors. Furthermore, EGCG and its derivatives are used in proteasome inhibition and they are involved in epigenetic mechanisms.
Uji Potensi Triterpenoid dari Kulit Batang Waru Jawa (Hibiscus tiliaceus L.) sebagai Kandidat Antiinflamasi pada Mencit (Mus musculus) Model Rheumatoid Arthritis Berbasis in Silico Lisa Savitri; Elfred Rinaldo Kasimo; Datin An Nisa Sukmawati; Syntia Tanu Juwita; Eka Wahyuningtiyas; Ana Retnowati
Jurnal Ilmiah Universitas Batanghari Jambi Vol 21, No 3 (2021): Oktober
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v21i3.1619

Abstract

Waru jawa (Hibiscus tiliaceus L.) is a plant that functions as an anti-inflammatory. Compounds from the waru jawa plant, especially the bark can be grouped into alkaloids, flavonoids, triterpenoids, and steroids. The content of triterpenoids from the waru jawa stem bark was tested for their biochemical activity, so that it is expected that the bark of Javanese waru stems can be used optimally. This study aims to determine the potential of triterpenoids from waru jawa stem bark as anti-inflammatory candidates in mice (Mus musculus) rheumatoid arthritis model in silico-based. Potential analysis of triterpenoids in mice was carried out using the STITCH, which is a database of known and predicted interactions between chemicals and proteins found in living things. Interactions in question are physical and functional associations, the data contained in STITCH comes from computational predictions, transfer of knowledge between organisms, and from interactions collected from other databases. Analysis of the triterpenoid mechanism of waru jawa stem bark against rheumatoid arthritis model mice in silico-based using the bioinformatics application Kegg. Based on the results of the analysis, it can be seen that triterpenoids derived from waru jawa stem bark sources play an important role in reducing inflammation. The triterpenoids target NF-κB, leading to its downregulation. Triterpenoids have been found to have many functions, although their effective concentrations for various cellular effects may vary widely. Depending upon the dose administered, triterpenoids can induce anti-inflammatory, proliferation-arresting, apoptotic effects, cytoprotective, and tumor-differentiating.
Co-Authors Akbar Nur Kholis Ana Retnowati Arif Nurma Etika Bella Ainun Eka Wardani Datin An Nisa Sukmawati Datin An Nisa Sukmawati Eka Wahyuningtiyas Erik Irham Lutfi Ester Lianawati Antoro Evi Husniati Sya'idah Evi Husniati Sya'idah Ida Septika Wulansari Iza Dwi Muslikha Lian Pandu Farendra Lisa Savitri Moh Alimansyur Mujtahid Bin Abd. Kadir savitri, Lisa Stanislaus Rachel Pringgadani Syntia Tanu Juwita Syntia Tanu Juwita Tontowi Jauhari