Article Per Year (5 Year)
p-Index From 2020 - 2025
4.266
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Lingkungan Majalah Geografi Indonesia JURNAL PEMULIAAN TANAMAN HUTAN Journal of Degraded and Mining Lands Management Indonesian Journal of Pharmaceutical Science and Technology Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Journal of Tropical Biodiversity and Biotechnology EnviroScienteae Biosaintifika: Journal of Biology & Biology Education Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) Jurnal Surya Masyarakat Surya Abdimas ACROPORA: Jurnal Ilmu Kelautan dan Perikanan Papua East Asian Journal of Multidisciplinary Research (EAJMR) Jurnal Pengabdian Papua JURNAL BIOLOGI PAPUA Jurnal Manusia dan Lingkungan Bakti Hayati
Rosye H.R. Tanjung
Univeristas Cenderawasih
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

Published : 53 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Cytotoxic Activity and Phytochemical Analysis of Breynia cernua from Papua Dirgantara, Septriyanto; Tanjung, Rosye H.R.; Maury, Hendra K.; Meiyanto, Edy
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (421.159 KB) | DOI: 10.15416/ijpst.v1i1.16121

Abstract

Breynia cernua (local name Katuk Hutan) is an Indonesian medicinal plant (family: Euphorbiace- ae) originated from Papua which have been used traditionally as alternative treatment for breast and cervical cancer. The objectives of this research were to investigate potential cytotoxic activity and phytochemical aspect test of B. cernua extract and its fractions. Extraction was performed by macera- tion using ethanol 96%, followed by successive fractionations. Phytochemical screening and in vitro cytotoxic activity test were obtained for extract and active fraction with Brine Shrimp Lethality Test (BSLT) method and MCF-7 tumor cell lines were assessed by 3-(4-5-dimethylthiazol-2yl)-2,5-diphe- nyl tetrazolium bromide (MTT) assay. The results from cytotoxic activity test of breast cancer MCF-7 cell line from ethanolic 96% extract and three fractions: n-hexane, ethylacetate and water fractions showed 246.841 ppm, 165.65 ppm, 562.57 ppm dan 713.78 ppm respectively meanwhile the IC50 value of doxorubicin as the positive control was 6 μM. TLC and phytochemical screening showed the pres- ence of alkaloids, terpenoid, avonoids and tannins compounds in this active plant. Keywords: Antitumor, Breynia cernua, BSLT, MCF-7
Co-Authors Agamawan, Lalu Panji I. Agnes Kabelen Agnes Kabelen, Agnes Akrom, Akrom Alfred A Antoh Ali Djamhuri Alianto , Baigo Hamuna Baigo Hamuna Baigo Hamuna Baigo Hamuna Baigo Hamuna Basa T Rumahorbo Cahyaningsih, Ayu Daniel Lantang Dewi Sulistiowati Dwi Haryanto Dwi Haryanto Edy Meiyanto Efray Wanimbo Elsye Gunawan Eni Miton Busup Erni Unenor Erni Unenor, Erni Ervina Indrayani Fali Sembori Fali Sembori Floriana Kabelen Hanna E. Samosir Helena G Burok Helena G. Burok Henderina J. Keiluhu Henderina J. Keiluhu Hendra Kurniawan Maury Ign. Joko Suyono Irma A. Resmol Irma Rahayu Irma Rahayu, Irma Jane T. Sada Jane T. Sada Jhon D. Kalor Jhon D. Kalor John D Kalor Juwita Juwita Kabes, Wetty Queenisa Kalvin Paiki Komari Komari Konstantina M.B. Kameubun Konstantina M.B. Kameubun Kristopholus Rumbiak Lantang , Daniel Lisiard Dimara Lisye I. Zebua Lisye I. Zebua Lisye I. Zebua Lisye Iriana Zebua Lisye Iriana Zebua Lucia Runggeari Lucia Runggeari Mahmudi Mahmudi Maklon Warpur Manalu, Khristhoper Aris A. Manwan, Sri Wahyuni Marcelino N. Yonas Marthen L.R. Bartholomeus Mathen L.R. Bartholomeus Meidy J. Imbiri Mesak Kamarea Mesak Kamarea Mesak Kamarea Nelince Fakdawer Nurtanti Handono Nurtanti HAndono Parjan Parjan Pulle, Yosevin H. Purwanto Purwanto Purwanto Purwanto R. Rijanta Rejauw, Korinus Rini Patandungan Rini Patandungan Runtuboi, Dirk Yanes Saebu, Yusuf Sammaria J. Karma Septriyanto Dirgantara Sipriana Dogomo Siregar, Martha D. Suharno Suharno Suharno Suharno Suharno Suharno Suharno Suharno Suharno, _ Supeni Sufaati Supeni Sufaati Supeni Sufaati Supeni Sufaati Supeni Sufaati Supeni Sufaati Suriani B.R. Surbakti Suriani Br. Surbakti Suwito Suwito Suwito Suwito Suwito Suwito Totok A. Mushid Tri Gunaedi Verena Agustini Verena Agustini Verena Agustini Verena Agustini Wahyu Dwi Nugroho Wigati Yektiningtyas Wigati Yektiningtyas Yan P. Yepese Yan Piet Yepese Yayan Sopian Yemeus Helakombo Yuliana Ruth Yabansabra Yuliana Yuliana Yulius Sarungu Yunus Pajanjan Paulangan Ziyadatun Ni'mah