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Adrian Umboh
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Jurnal Kedokteran Klinik

 1 
PERBANDINGAN JENIS KONSUMSI AIR MINUM DENGAN KRISTALURIA PADA ANAK Umboh, Adrian; Umboh, Valentine
JKK (Jurnal Kedokteran Klinik) Vol 1, No 2 (2017): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

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The sources of  drinking water should be qualified both in chemistry, physics, radioactive or bacteriological. One of the parameters in terms of the quality of water is the amount of deposits of minerals such as calcium and magnesium ions. Water consumption of high calcium can increase urine calcium excretion and the process of early occurrence of kidney stones. This research aims to analyze the difference of urinary calcium excretion in children based on the consumption of well water, bottled water and water from a drinking water company and there is not kristaluria. The design of the study was observational, analytic approach to cut the latitude. This research was conducted in three places, on the island of Gangga, Manado and Bitung in April until the month of November 2016. Urinary calcium excretion was measured by calculating the ratio of urine calcium against creatinin urine. And measured also levels of calcium in drinking water. Data were analyzed with Anova test followed by the Fisher test is meaningful and logistical regression. The result p 0.05 was considered meaningful <. On this research obtained 112 children met the criteria of inclusion, the mean excretion of urinary calcium is obtained from the overall sample is 0.143 mg/dl. There is a very meaningful distinction between samples mengkonsumi water Company drinking water and bottled water as well as samples that consume water Company drinking water and well water with a value of p < 0.0001. In the sample who consume bottled water and well water not obtained urine calcium excretion that difference means p = 0.073. In this study also brings about the relationship between calcium excretion meaning apparent urine hiperkalsiuria of events. These relationships meet the logistical regression equations p = 1/1 + e (0,722-+4, 55x). From this research it can be concluded that calcium levels from each different drinking water and may cause a difference in calcium excretion of urine as well as related events kristaluria. Key words: water, kristaluria, kidney stones
HUBUNGAN MATRIXMETALLOPROTEINASES-9 DAN THROMBOSPONDIN-1 DENGAN TEKANAN DARAH PADA ANAKDENGAN RIWAYAT BERAT LAHIR RENDAH Umboh, Adrian; Wilar, Rocky; Bernadus, Janno B. B.
JKK (Jurnal Kedokteran Klinik) Vol 3, No 1 (2019): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

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AbstractDisorders of endothelial function that occur in low-weight infants can result in increased levels of Metallo proteinases-9 (MMP-9) and Thrombospondin-1 (TSP-1) and are associated with increased blood pressure. MMP-9 is a family of endopeptidaseszinc-dependent that is responsible for tissue remodeling, both physiological and pathophysiological. The purpose of this study was to see the relationship between MMP-9 and TSP-1 with birth weight and blood pressure in children with a history of low birth weight. This study was a correlational observational analytic with cross sectional approach, namely by looking at the relationship between MMP-9 and TSP-1 levels with birth weight and blood pressure. This research was conducted from April to October 2018 at RSUP Prof. Dr. R. D Kandou Manado, North Sulawesi in children aged 7-9 years with a history of low birth weight. Blood pressure is measured by sfigmano meter. Inclusion criteria are children in good health with good nutritional status, having birth weight records in medical records, and parents willing to sign informed consent. Exclusion criteria were children in sick condition, taking drugs in 2 weeks before the study, obesity and suffering from kidney disease. MMP-9 levels measured by the enzyme-linked Quantikine Human MMP-9 method and TSP-1 levels were measured by the R & D System human thrombospondin-1 immunosorbent assay method.Keywords: Metallo proteinases-9 Matrix, Thrombospondin-1, low birth weight, blood pressure AbstrakGangguan fungsi endotel yang terjadi pada bayi berat lahi rrendah dapat mengakibatkan  terjadinya  meningkatnya  kadar  Matrix  Metallo  proteinases-9 (MMP-9) dan Thrombospondin-1(TSP-1) serta berhubungan dengan   peningkatan tekanan  darah.  MMP-9  adalah keluarga dari endopeptidaseszinc-dependent  yang bertanggungjawab untuk remodeling jaringan, baik fisiologis maupun patofisiologis. Tujuan penelitian ini untuk Melihat hubungan MMP-9 danTSP-1 dengan berat badan lahir dan tekanan darah pada anak dengan riwayat berat lahir rendah. Penelitian ini bersifat observasional analitik korelatif dengan pendekatan potong lintang yaitu dengan melihat hubungan kadar MMP-9 dan TSP- 1 dengasn berat lahir dan tekanan darah. Penelitian ini dilakukan mulai bulan April sampai  Oktober  2018  pada RSUP Prof. Dr. R. D Kandou Manado, Sulawesi Utara pada anak usia7-9 tahun dengan riwayat  berat  lahir rendah. Tekanan darah diukur dengan sfigmano meter. Kriteria inklusi adalah anak dalam keadaan sehat dengan status gizi baik, memiliki catatan berat lahir dalam rekam medis, dan orang tua bersedia untuk menanda tangani informed consent. Kriteria eksklusi adalah anak dalam kondisi sakit, mengkonsumsi obat- obatan dalam 2 minggu sebelum penelitian, obesitas dan menderita penyakit ginjal. Kadar MMP-9 diukur dengan metode Human MMP-9 enzyme-linked Quantikine dan kadar TSP-1   diukur   dengan   metode   R&D   System   human   thrombospondin- 1immunosorbent assay kit.Katakunci: Matrix Metallo proteinases-9,Thrombospondin-1, berat lahir rendah,tekanan darah
Analisis Hubungan Angka Kejadian, Gambaran Klinik Dan Laboratorium Anak Dengan Sindrom Nefrotik Resisten Steroid Di RSUP Prof. Dr. R. D. Kandou Manado Suwontopo, Marvin Leonardo; Umboh, Adrian; Wilar, Rocky
JKK (Jurnal Kedokteran Klinik) Vol 4, No 1 (2020): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

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ABSTRAKSindrom Nefrotik (SN) adalah penyakit Ginjal paling sering pada anak yang ditandai dengan Edema beserta Proteinuria, Hipoalbuminemia dan Hiperkolesterolemia. Menurut Respon Pengobatan, SN dibagi menjadi Sindrom Nefrotik Resisten Steroid (SNRS), dan Sindrom Nefrotik Sensitif Steroid (SNSS). Penelitian ini bertujuan untuk mengetahui hubungan Angka Kejadian, Gambaran Klinik dan Hasil Laboratorium pasien anak dengan Sindrom Nefrotik Resisten Steroid. Penelitian ini adalah penelitian Retrospektif Analitik yang dilaksanakan di  Bagian Ilmu Kesehatan Anak RSUP Prof Dr. R. D. Kandou Manado dengan mengambil data Rekam Medik dari periode Juli 2016 – Juni 2019. Perhitungan angka kejadian dengan menggunakan Period Prevalence dan variabel yang diteliti yaitu: Umur, Jenis Kelamin, Edema, Hipertensi, Hematuria, kadar Protein Urin, kadar Albumin Serum, kadar Kolesterol Serum, kadar Ureum Serum, dan kadar Creatinine Serum. Analisis Statistik dilakukan dengan menggunakan Uji Chi Square dan Uji Korelasi Spearman. Hasil Penelitian menunjukkan terdapat 35 pasien SN terdiri dari 21 pasien (60%) SNRS dan 14 pasien (40%) SNSS. Angka Kejadian SNRS dalam penelitian ini sebanyak 18,1%. Tidak didapatkan hubungan pada Variabel Umur (p=0.568), Edema (p=1.000), Hipertensi (p=0.392), Hematuria (p=0.058), Albumin Serum (p=0.324), Kolesterol Serum (p=0.234), Ureum Serum (p=0.445), Creatinine Serum (p=0.445). Hubungan didapatkan pada Variabel Jenis Kelamin (p=0.028) (r=0.371), dan Protein Urin (p=0.001) (r=0.557). Kesimpulan Jenis Kelamin Laki – laki dan Protein Urin ≥ +3 berpengaruh terhadap terjadinya Resistensi Steroid pada pasien anak dengan SN.Kata Kunci: Sindrom Nefrotik, SNSS, SNRS, Jenis Kelamin, Proteinuria. ABSTRACTNephrotic Syndrome (SN) is the most common Kidney Diseases in children characterized by Edema with Proteinuria, Hypoalbuminemia and Hypercholesterolemia. Based on Treatment Response, SN is divided into Steroid Resistant Nephrotic Syndrome (SRNS), and Steroid Sensitive Nephrotic Syndrome (SSNS). This study aims to determine the relationship of Prevalence, Clinical and laboratory features of Children with Steroid Resistant Nephrotic Syndrome. This is an Analytical Retrospective study carried out in the Department of Pediatric Medicine in Prof. Dr. R. D. Kandou General Hospital Manado by taking Medical Record data from the period of July 2016 - June 2019. Period Prevalence is used to calculate the Prevalence of SRNS. Studied Variables are: Age, Gender, Edema, Hypertension, Hematuria, Urine Protein level, Serum Albumin level, Serum Cholesterol level, Serum Ureum level, and Serum Creatinine level. Statistical analysis was performed using the Chi Square Test and the Spearman Correlation Test. Results showed there were 35 NS patients consisting of 21 SRNS patients (60%) and 14 SSNS patients (40%) SNSS. The Period Prevalence of SRNS  in this study was 18.1%. No Significant Correlation was found in Age (p = 0.568), Edema (p = 1,000), Hypertension (p = 0.392), Hematuria (p = 0.058), Albumin (p = 0.324), Cholesterol (p = 0.234) Ureum (p = 0.445), Creatinine  (p = 0.445). Significant Correlation were found in Gender (p = 0.028) (r = 0.371), and Urine Protein (p = 0.001) (r = 0.557). Conclusion. Male Gender and Urine Protein ≥ + 3 are associated with Steroid Resistance in NS patients.Keywords= Nephrotic Syndrome, SSNS, SRNS, Gender, Urine Protein.
Analisis laboratorium Anak Glomerulus Nefrotik Akut Paska Streptokokus di Bangsal Anak Prof.DR. R.D. Kandou Hospital Sanusi, Holly; Umboh, Adrian; Umboh, Valetine
JKK (Jurnal Kedokteran Klinik) Vol 3, No 2 (2019): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

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ABSTRACTBackground: Acute post-streptococcal acute glomerulonephritis (GNAPS) is the most common type of glomerulonephritis in childhood. Acute glomerulonephritis (GNA) is characterized by acute onset of edema, hematuria, and hypertension, and is usually associated with oliguria and azotemia. Method: This research is a retrospective study by taking data from the medical records of children's ward Prof. Dr. RD Kandou Manado with a diagnosis of Acute Glomerulonephritis after Streptococcus with an interval of 5 years. By looking at laboratory values. Results: From the results of a complete blood test, there were 40 children (78%) with Hb levels above normal, 36 children (70%) leukocytes increased, 37 children (72%) LEDs above normal, 41 children (80%) ASTO > 200 IU, 6 children (11%) CRP increased, 27 children (52%) C3 decreased, 32 children (62%) creatinine urea increased. Potassium is below normal for 9 children (19%), Potassium is more than normal for 4 children (9.8%), serum sodium is below normal for 18 children (37%). Microscopic erythocytes are positive in 100% of children, macroscopic 42% of children. Conclusion: Microscopic haematuria is a sign found in all GNA sufferers, followed by increased ASTO, increased LEDs, increased leukocytes, and increased creatinine urea.Keyword : GNAPS, GNA, Laboratory Analysis,Post Streptococal Infection ABSTRAKLatar belakang: Glomerulonefritis akut pasca streptokokus (GNAPS) adalah jenis glomerulonefritis yang paling umum  pada masa kanak-kanak. Glomerulonefritis akut (GNA) ditandai oleh onset akut edema, hematuria, dan hipertensi, dan biasanya berhubungan dengan oliguria dan azotemia. Metode: Penilitian ini merupakan studi retrospektif dengan mengambil data dari rekam medis bangsal anak RSUP Prof dr. RD Kandou Manado dengan diagnosa Glomerulonephritis Akut Paska Streptococcus dengan selang waktu 5 tahun. Dengan melihat nilai laboratorium. Hasil: dari hasil pemeriksaan darah lengkap didapatkan, terdapat 40 anak (78%)  dengan kadar Hb di atas normal, 36 anak (70%) leukosit meningkat,  37 anak (72%) LED di atas normal, 41 anak (80%) ASTO > 200IU , 6 anak (11%) CRP meningkat, 27 anak (52%) C3 menurun, 32 anak (62%) ureum kreatinin meningkat. Kalium di bawah normal 9 anak (19%), Kalium lebih dari normal  4 anak (9,8%), natrium serum dibawah normal 18 anak (37%). Eritosit mikroskopik positif pada 100% anak, makroskopik 42% anak. Kesimpulan: Hematuria mikroskopik merupakan tanda yang ditemukan pada semua penderita GNA, diikuti oleh ASTO meningkat, LED meningkat, leukosit meningkat, dan ureum kreatinin meningkat.Kata kunci : GNAPS, GNA, Analisis Laboratorium,Post infeksi Streptococus
Luaran Pada Anak-Anak Dengan Sindroma Nefrotik Sensitif Steroid Di RSUP PROF. Dr. R. D. Kandou Manado Umboh, Valentine; Tandiawan, Ledy; Umboh, Adrian
JKK (Jurnal Kedokteran Klinik) Vol 3, No 2 (2019): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

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ABSTRACTBackground : Nephrotic Syndrolme (NS) is the most common kidney disorder in children. Based on therapy, NS consist of steroid sensitive nephotic syndrome (SSNS) ans steroid resistant nephrotic syndrome (SRNS). Nearly 50% of children with SSNS have a frequently relapsing (FR) or steroid dependent (SD) course, experiencing steroid toxicities. Objective :To examine the outcome in childrens with SSNS at Prof. DR. R.D.Kandou Manado Hospital  Methods : A retrospective study of patients from January 2013 to December 2017. 123 of patients diagnosed SSNS, from 6 month to 18 years of age admitted in the Pediatric Nephrology clinic of Prof. DR. R.D.Kandou Manado Hospital. We record the clinical and laboratory presentation of these patients from medical records. Result : Sample (n=123) children with SSNS. 62 children  include inclusi criteria. There are 36(58%) children experience FRNS, and 26(42%) children experience SDNS. The median age of onset was 36 months. The median time to the first relapse was 3 months in FRgroup, and 14 day in SD group. There are 9(25%) children with FR and 6(23%) with SD,  experiences SRNS. Conclusion : Treatment in the first periode and shorter median time in SSNS is a predictor of FRNS or SDNS.Keywords : Nephrotic syndrome, sensitive steroid, steroid resistant, steroid dependent, frequent relap.ABSTRAKLatar Belakang : Sindroma Nefrotik (SN) merupakan kelainan ginjal tersering pada anak. Berdasarkan respon terhadap terapi, SN dibagi menjadi Sindrom Nefrotik Sensitif Steroid (SNSS) dan Sindrom Nefrotik Resisten Steroid (SNSR). Sebagian besar anak dengan SNSS memiliki kemungkinan terjadi sindrom nefrotik relaps sering (SNSR) atau sindrom nefrotik tergantung steroid (SNDS), dikarenakan mengalami toksisitas steroid Tujuan : Untuk melihat luaran dari anak-anak dengan SNSS di RSUP Prof. Dr. R. D. Kandou Manado. Metode : Penelitian retrospektif, yang dilakukan pada anak-anak dengan diagnosa SNSS dari Januari 2013 sampai dengan Desember 2017, yang dirawat di unit rawat jalan Nefrologi anak bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado. Data pemeriksaan dan hasil laboratorium diambil dari rekam medis  Hasil : Sample (n=123) anak dengan SNSS. 62 anak yang termasuk kriteria inklusi. Didapatkan 36 (58%) anak menfalami SN relap sering, dan 26 (42%) anak mengalami SN dependen steroid. Dengan rata-rata umur onset yaitu 36 bulan.  Dan rata-rata waktu kambuh pertama kali adalah 3 bulan pada relaps sering dan 14 hari pada kelompok dependen steroid. Dan didapatkan 9 (25%) anak dengan relaps sering dan 6 (23%) anak dengan dependen steroid mengalami sindrome nefrotik resisten steroid. Kesimpulan : Pengobatan adekuat pada episode pertama dan waktu paruh yang singkat pada pengobatan SNSS merupakan prediktor terjadinya SN relaps sering atau SN dependen steriod.Kata kunci     : Sindroma nefrotik, steroid sensitif, resisten steroid, dependen steroid, relaps sering.        
Co-Authors Aaltje E. Manampiring Aaltje Ellen Manapiring Aaltje Manampiring Abram Babakal Adi Suryadinata Krisetya Alan J. Jufri Algi Reafanny Batara Amatus Yudi Ismanto Andi Dwi Bahagia Febriani Andrian Aldo Rantung Angelya Lumoindong Angie G. Roring, Angie G. Ango, Putri C. Ari L. Runtunuwu Ari Runtunuwu Astrid A. Malonda Baksh, Aida K. Bernadus, Janno Berty Bradly Chensilya Kusumanarwasti Christien Gloria Tutu Corona, Fidel Damaris, Damaris David E Kaunang David Kaunang Drova Grano Manorek Eka Patandianan Elia A. P. Hutapea Erling D. Kaunang Fatimawali . Frecillia Regina Herwanto Herwanto Hesti Lestari Hesti Lestari Hidayani, Agung R.E Hosang, Kevin H. Irawan Yusuf Iwan P. Wawointana, Iwan P. Jane A. Kalangi Jeanette I. Ch. Manoppo Jeanette I. Ch. Manoppo, Jeanette I.Ch. Manoppo Jenifer Andalangi Johannes Edwin Johnny Rompis Jose M. Mandei Jose M. Mandei Jully Kasie Kartini W. Adam Kristellina Tirtamulia Kromo, Lucky Kurniawan Tan Lasidi, Oktifani Devi Liow, Jackli Eugene Lonto, Jesica S. Lumingkewas, Pitter Handry Lydia Tendean Maki, Frindi Manopo, Berry R. Manoppo, Jeanette Irene Christiene Mantali, Rizqa Mantik, Keren E.K. Maria Fitricilia Marianne C. Jacobus, Marianne C. Matthew, Febriano Max F. J. Mantik Max F.J Mantik, Max F.J Natharina Yolanda, Natharina Nilawati, . Novie H. Rampengan Novie Homenta Rampengan, Novie Homenta Nurhayati Masloman Oktavin Yollah Umboh Paulina N. Gunawan Phan, Sardito Pinaria, Anthoneta S. Polii, Evan G. Praevilia M. Salendu Queen Mandang Reifanli M. Pai, Reifanli M. Robin Samuel Mamesah, Robin Samuel Rocky Wilar Rompies, Ronald Ronald Chandra Sabriani, Jehan Sanusi, Holly Sarah M. Warouw Sarah Warouw smanto, Yudi Stefanus Gunawan Stefanus Gunawan Stevanus Gunawan, Stevanus Surya, Welong S. Suryani As’ad Suwontopo, Marvin Leonardo T. A. Sudjono Taliwongso, Fernando Ch. Tandiawan, Ledy Tatipang, Pirania Ch. Umboh, Indria M. Umboh, Valetine Valentine Umboh Valentine Umboh, Valentine Vicky M. Kalangie, Vicky M. Vini Maleke, Vini Vivekenanda Pateda Vivekenanda Pateda Waworuntu, David S. Yanni, Iloh Devi Yolanda B. Bataha