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All Journal Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Folia Medica Indonesiana Global Medical and Health Communication Medical Laboratory Technology Journal JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal Pengabdian Pada Masyarakat Majalah Patologi Indonesia Jurnal Neuroanestesi Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Eduvest - Journal of Universal Studies Media Dermato-Venereologica Indonesiana
Hermin Aminah Usman
Universitas Padjadjaran
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Majalah Patologi Indonesia

 1 
Analisis Imunoekspresi Programmed Death Ligand 1 (PD-L1) dan Indeks Proliferasi Ki-67 pada Tumor Astrositik Difus Billy Parulian Lubis; Hasrayanti Agustina; Hermin Aminah Usman; Bethy Surjawathy Hernowo; Sri Suryanti; Ahmad Faried; Hendrikus Bolly
Majalah Patologi Indonesia Vol 29 No 2 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.15 KB) | DOI: 10.55816/mpi.v29i2.418

Abstract

BackgroundDiffuse astrocytic tumours (DAT) is a diffuse infiltrative astrocytoma tumor accompanied by molecular parameters in the form or absence ofIsocitrate Dehydrogenase (IDH) gene mutations. The DAT category without the examination of the IDH gene mutation is classified as NotOtherwise Specified (NOS). Ki-67 is a marker for DAT proliferation so that it can assess the degree of DAT. Diffuse astrocytic tumoursbehavior is influenced by proliferative ability and the presence of a tumor microenvironment. The tumor microenvironment PD-L1 factorinfluences DAT behavior and allows the development of target therapy in DAT cases. This study aimed to analyze the relationship betweenPD-L1 and Ki-67 imunoexpression in the histopathological degree of DAT.MethodsCross-sectional study of 30 paraffin blocks of DAT NOS cases from 2014-2018 in the Department of Anatomical Pathology RSUP dr. HasanSadikin, Bandung. The sample consisted of 15 cases of grade II, 7 cases of grade III and 8 cases of grade IV, carried outimmunohistochemical staining with GFAP, PD-L1 and Ki-67. Assessment of PD-L1 immunoexpression was carried out by the histoscoremethod. The Ki-67 assessment was assessed based on its distribution, which was <10% and ≥10%. PD-L1 and Ki-67 immunoexpressionwith histopathological degrees in DAT were statistically analyzed by Kolmogorof Smirnov test, however association betweenimmunoexpression of PD-L1 and Ki-67 were analyzed by chi-square test.ResultsThere was a significant relationship between PD-L1 immunoexpression and histopathological degree in DAT (p=0.005). There was asignificant relationship between Ki-67 immunoexpression and DAT histopathology degree and with PD-L1 (p=0.001 and p=0.010).ConclusionPD-L1 immunoexpression and proliferation rates affect the degree of DAT. Proliferation rate of DAT is influenced by PD-L1 so that in thisstudy, PD-L1 and Ki-67 can be used as a marker of prognosis predictors.
Karakteristik klinikopatologikal Mucoepidermoid Carcinoma kelenjar liur di Rumah Sakit Umum Pusat dr Hasan Sadikin (RSHS) Bandung tahun 2013-2022: A 10 Year review Noor Fitriana, Maya; Usman, Hermin Aminah; Yantisetiasti, Anglita
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.596

Abstract

Background Primary salivary gland malignancy is rare and has limited reports. Mucoepidermoid Carcinoma (MEC) is the most common malignant tumor of the salivary glands. However, epidemiological reports on salivary gland MEC are still limited, particularly in Indonesia. This study aimed to report the clinicopathological characteristics of Salivary gland MEC in dr Hasan Sadikin Central Hospital (RSHS) from January 2013 to December 2022. Method: This study is a descriptive study with a cross-sectional method. Total cases of salivary glands MEC that were histopathologically diagnosed and recorded in the RSHS Hospital Information System (SIRS) medical records from 2013 to 2022 were collected. It is included demographic, clinical, and histopathological data. Result A total of 86 MEC cases were diagnosed histopathologically between 2013 and 2022. The cases involved 44 (51,2%) females and 42 (48,8%) males. The mean age is 46,4 years old. The most common site affected is a parotid gland (37,2%). According histopathological grade, 51,2% were high grade, 25,6% were intermediate grade, and 23,3% were low grade. The result of clinical stage is Stage III has the highest percentage (n=32, 37,2%). The majority of patients receive surgical combined with radiotherapy treatment (n=53; 61,6%). Conclusion There are 86 cases of Salivary MEC in RSHS period 2013-2022. MEC is common in females, mean age 46,4 years old. Parotid gland is the most common site. The most frequent histopathological grading and clinical staging are high grade and stage III. Keyword Mucoepidermoid carcinoma, salivary gland, clinicopathological, RSHS
Co-Authors . Afiati, . Abdul Hadi Hassan, Abdul Hadi Afiati Afiati Afiati Afiati Ahmad Faried Anglita Yantisetiasti Anjani, Gebby Reviana Apriliani, Ardhia Rizki Arif, Izhar Muhammad Arif, Izhar Muhammad Arima Kurnia Sari Dewi Nurcahyani Astrid Feinisa Khairani Atika Hana Ilyasa Bashari, Muhammad Hasan Bethy Surjawathy Hernowo Bethy Surjawathy Hernowo Bethy Suryawathy Hernowo Billy Parulian Lubis Defi Ardia Pramesti Dewayani, Birgitta Maria Dewi Yulianti Bisri Dika Widia Nur Azizah Dimas Erlangga Luftimas Dimas Erlangga Luftimas Dolvy Girawan Dwi Andini Edward Jaya Hadi Egie Rahmalaelani Eka Surya Nugraha Erida, Yulie Fauzan Ali Zainal Abidin Gian Nugraha Gurwinder Kaur a/p Gurcharan Singh Gurwinder Kaur a/p Gurcharan Singh Hasrayanti Agustina Hasrayati Agustina HENDRA GUNAWAN B11211055 Hendrikus Bolly Herry Yulianti Jessica Oktavianus Trisaputra Jono Hadi Agusni Jono Hadi Agusni, Jono Hadi Khafifah, Dinda Salsa Labibah, Salma Nur Lala Yuliani Laraswita, Sarah Meinarni, Retno Misuari Sabirin, Muhammad Syah Muhammad Begawan Bestari Nadiah, Zahra Nadifah Diana Zalia Naura Mardhiyah Nenny Agustanti Nita Novita Noor Fitriana, Maya Novi Vicahyani Utami Nugraha, Marwan Agung Nurhasanah Nurhasanah Nurhidayat, Ade Apon Putri Halleyana Rahmalaelani, Egie Rahman, Putri Halleyana A Ramdhani, Muhammad Farid Rani Septriana Rani Septrina Rania Azzahra Salsazayasya Parikesit Rasdianto, Devi Novianto Reti Hindritiani Rianty, Fathia Rika Mustika Risqi Dwi Putra Sholihah, Fitria Siska Dwiyantie Wahyuni Siti Aminah Abdurachman Sri Suryanti Sunardi, Mas Adi Titing Nurhayati Trisaputra, Jessica Oktavianus Yudi Wahyudi Yunnica Yunnica Zahra Nurusshofa