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All Journal Journal of Food and Pharmaceutical Science Jurnal Informatika Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Abdimas Dewantara Media Farmasi WIDYA LAKSANA Aplikasia: Jurnal Aplikasi Ilmu-Ilmu Agama PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journals of Ners Community Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Cendekia Eksakta Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Indonesia Berdaya Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Mitra Masyarakat (JPMM) Journal of Food and Pharmaceutical Sciences Jurnal Pengabdian Masyarakat Panacea Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

Iis Wahyuningsih

Fakultas Farmasi, Universitas Ahmad Dahlan

Author-ID : 411469

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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FORMULASI TABLET SERBUK PISANG RAJA (Musa xparadisia AAB) SEBAGAI PENUTUP TUKAK LAMBUNG PADA TIKUS Wahyuningsih, Iis
PHARMACIANA Vol 2, No 1: Mei 2012
Publisher : PHARMACIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB)

Dari kajian empiris maupun beberapa penelitian terbukti pisang raja (Musa xparadisia AAB) mempunyai potensi untuk dikembangkan menjadi sediaan gastroprotektor melalui mekanisme efek mukoadhesif. Sehingga diperlukan penelitian lanjutan untuk dibuat sediaan yang lebih praktis, stabil dan mempunyai dosis yang lebih seragam. Pada penelitian ini dipilih bentuk sediaan tablet yang mempunyai beberapa kelebihan seperti : praktis, aman dan relatif mudah pembagian dosisnya. Penelitian yang dilakukan meliputi : identifikasi buah pisang raja, pembuatan serbuk pisang raja, pembuatan tablet serbuk pisang raja, uji sifat fisik tablet serbuk pisang raja, uji mukoadhesif tablet serbuk pisang raja secara in vivo dengan menggunakan lambung tikus.Tablet serbuk pisang raja yang dihasilkan memenuhi kriteria tablet yang baik. Tablet serbuk pisang raja yang dihasilkan mempunyai kemampuan menutup tukak lambung tikus yang diinduksi dengan alkohol. Efektivitas efek mukoadhesif tablet serbuk pisang raja yang dihasilkan tidak berbeda bermakna dibandingkan dengan sukralfat (p > 0,05).

BIOAVAILABILITAS TABLET IBUPROFEN PADA PEMBERIAN BERSAMAAN DENGAN EKSTRAK AIR HERBA PEGAGAN (Centella asiatica (L) Urban) PADA KELINCI JANTAN Wahyuningsih, Iis; Sutanti, Depprelia Wahyu
PHARMACIANA Vol 3, No 1: Mei 2013
Publisher : PHARMACIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB)

Kecenderungan masyarakat menggunakan obat herbal bersamaan dengan obat sintetik dapat mengakibatkan terjadi interaksi. Penelitian ini dimaksudkan untuk mengetahui pengaruh ekstrak air herba pegagan (Centella asiatica (L) Urban) terhadap bioavailabilitas tablet ibuprofen pada kelinci jantan, dimana ibuprofen dan ekstrak air herba pegagan dimetabolisme oleh enzim CYP450 yang sama denganmekanisme yang berbeda. Penelitian ini menggunakan rancangan sama subyek dengan design Cross Over menggunakan subyek uji 5 ekor kelinci jantan. Setiap kelincimendapatkan perlakuan yang sama. Sampel kontrol diberi tablet ibuprofen 400 mg, sedangkan sampel perlakuan diberi tablet ibuprofen 400 mg bersamaan dengan ekstrak air herba pegagan dengan konsentrasi 25 %b/v, 50 %b/v dan 100 %b/v.Kemudian diambil darahnya pada jam ke 0; 0,5; 1; 1,5; 2; 2,5; 3; 3,5; 4; 6; 8; 10. Konsentrasi ibuprofen dalam plasma diukur menggunakan spektrofotometri. Konsentrasi ibuprofen yang diperoleh digunakan untuk mengukur parameterbioavailabilitas ibuprofen meliputi : tmaks, Cpmaks, and AUC. Data parameter bioavailabilitas yang dihasilkan dianalisis dengan uji ANOVA satu jalan dengan taraf kepercayaan 95 %. Hasil penelitian menunjukkan, penggunaan tablet ibuprofenbersama ekstrak air herba pegagan dapat meningkatkan nilai Cpmaks dan AUC, tetapi tidak ada pengaruh terhadap nilai tmaks. Penggunaan ibuprofen bersama ekstrak airherba pegagan 50 %b/v dan 100%b/v secara signifikan mempengaruhi bioavailabilitas ibuprofen dalam darah.

BIOAVAILABILITAS TABLET IBUPROFEN PADA PEMBERIAN BERSAMAAN DENGAN EKSTRAK AIR HERBA PEGAGAN (Centella asiatica (L) Urban) PADA KELINCI JANTAN Sutanti, Depprelia Wahyu; Wahyuningsih, Iis
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The tendency to use herbal drug simultaneously with synthetic drug may result inan interaction. Based on research, aqueous extract of Centella asiatica (L) Urbancontains saponin (asiaticoside and madecassoside) compounds that inhibit CYP450and is a safe herbal alternative that is used for anti-inflammatory treatment. The aim ofthis study was to investigate the effect of aqueous extract of Centella asiatica (L) Urbanto the ibuprofen tablet bioavailability in male rabbits. Both compounds are metabolizedby CYP450 enzymes in the same way with different mechanism. The cross over designwith the same subject was used in this study. The samples consisted of 400 mg ibuprofenwith 0%b/v, 25%b/v, 50%b/v dan 100%b/v aqueous extract of Centella asiatica (L)Urban respectively. The blood were taken after 0; 0,5; 1; 1,5; 2; 2,5; 3; 3,5; 4; 6; 8; 10hours after samples treatment, then the ibuprofen plasma concentration weredetermined spectrophotometrically. The results then were used to evaluat thebioavailability parameters: tmaks, Cpmaks, and AUC and were analyzed using ANOVAtest in the same way as well as the 95% trust standart. The results showed, the use ofibuprofen tablet stimultaneously with aqueous extract of Centella asiatica (L) Urbanincreased Cpmaks dan AUC, but there were no influence to the tmaks value. The use ofibuprofen tablet stimultaneously with 50 %b/v and 100 %b/v aqueous extract ofCentella asiatica (L) Urban had a significant influence to the bioavailability ofibuprofen.

EFEK ULCEROGENIC DISPERSI PADAT IBUPROFEN-POLIVINILPIROLIDON (PVP) PADA TIKUS PUTIH JANTAN Febrianti, Ririt Vita; Wahyuningsih, Iis
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ibuprofen is an anti inflammatory, analgesic, and antipyretic agent. It has low solubility and bioavailability.The administration of ibuprofen in a long time and high dose can increased of side effect at gastrointestinal (pepticulcer). This study was aimed to determine the influence its solid dispersions formation on ulcerogenic effect ofibuprofen buprofenis compared with ibuprofen alone and physical mixture. Solid dispersion of Ibuprofen-PVP(1:1) was prepared by solvent method. The ulcerogenic test was conducted by observing is white rat, dividedrandomly into 5 groups are healthy group (aquadest), suspending agent control (PVP 1%), drug (ibuprofen) at adose of 360 mg/kg body weight, group solid dispersion (ibuprofen-PVP) and group physical mixture(ibuprofen-PVP). Rats gastric was observed of formation ulcer and evaluated by scoring then followed thecalculation by the index ulcer. The results showed that the number of ulcer index of ibuprofen is 6,67. Number ofulcer index of solid dispersion was 4,00 and physical mixture was 3,34. The ulcerogenic effect of solid dispersionand physical mixture difference was significant (p<0,05) compared with ibuprofen alone. Ulcerogenic effectadministration of solid dispersion was smaller than ibuprofen alone and statistically no different (p>0,05)compared with physical mixture.

FORMULASI TABLET SERBUK PISANG RAJA (Musa xparadisiaca AAB) SEBAGAI PENUTUP TUKAK LAMBUNG PADA TIKUS Wahyuningsih, Iis
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Mucoadhesive is a topic of current interest in the design of drug delivery systemand treatment of peptic ulcers. This concept is based on the strength of adhesion of aprotective material to the mucosa. King Banana (Musa xparadisiaca AAB) is oftenused in the treatment of abdominal pain. It has been suspected having muchoadhesivestrength to cover peptic ulcer. The study was armed to formulate king banana tabletwhich has muchoadhesive ability to protect gastric mucosa become ulcer. The aim ofpeptic ulcer cover test was to see the ability of king banana tablet to covered ulcer at thegroups test that received different treatment of the negative control group (solvent), thebanana tablet suspension group, and sucralfate group. The ulcer severity wasdetermined by scoring method. All experimental data were tested by SPSS analyticalstatistics. The result showed that king banana tablet has similar strength to peptic ulcercover of sucralfat and not significantly different.

REDUCED ULCEROGENECITY FROM SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM OF PIROXICAM Wahyuningsih,M.Si., Apt, Iis; Widyaningsih, Wahyu; Wulandari, Silviana
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Piroxicam is antiinflammatory non-steroidal (AINS) drug group that has anti-inflammatory, analgesic and antipyretic effects. Like most other AINS drugs, piroxicam has low solubility and has gastrointestinal (ulcerogenic) side effects on long-term use. The nano-emulsifying drug delivery system (SNEDDS) is one of the technologies that can be used to overcome it. This study aims to determine the effect of ulcerogenic SNEDDS piroxicam compared with piroxicam formulas instead of SNEDDS. This study uses white rats male strain SD age 2-3 months and weight 100-200 grams of 40 rats. Rats divided into 5 groups. Group I was a normal control group, the test animals were given only water. Group II was a suspending control group treated with a 1% polyvinylpyrrolidone (PVP) solution, group III is a carrier control group treated with SNEDDS carrier which is a mixture of tween 80, virgin coconut oil (VCO) and polyethylene glycol (PEG) 400, group IV was a group of piroxicam drugs suspended with piroxicam 1.08 mg/kg in 1% PVP, group V was treated with SNEDDS piroxicam.Treatment was done for 28 days. After treatment, the gastric of rats were taken to be observed for ulcerogenic effects. Observations were made macroscopically by looking at ulcer scores followed by histopathological observations of tissue. The ulcer score data from each group were analyzed using one-way ANOVAand LSD test. The results showed that the normal control group, 1% PVP suspension and carrier group had a ulcer index of 0.0, 0.0 and 0.0, while the piroxicam suspension group and the SNEDDS group had an ulcer index of 0.88 and 0.0. These results were confirmed by histopathologic results of SNEDDS piroxicam to decrease the effect of pyroxicam ulcerogenic with results in the piroxicam suspension group has ulcer with necrosis by neutrophil infiltration, lymphocytes and mast cells in the mucosal tunica to submucosa. In the SNEDDS piroxicam group there is erosion with necrosis of the mucosal tunica epithelium with infiltration of lymphocytes and mast cells in submucosal tunica. It can be concluded the SNEDDS piroxicam can decrease the ulcerogenic effect.

Self-nanoemulsifying drug delivery system (SNEDDS) of piroxicam: evaluation on anti-inflammantory activity in wistar rats Yudha Rizky Nuari; Iis Wahyuningsih; Sekar Prabawati
Pharmaciana Vol 11, No 2 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used for arthritis, gout, and other musculoskeletal disorders. Piroxicam is poorly soluble in water and according to the biopharmaceutical drug classification system (BCS) is classified as a Class II drug with good permeability but poor dissolution. The self-nanoemulsifying drug delivery system (SNEDDS) has been extensively employed to improve the dissolution and absorption of water-insoluble drugs within the gastrointestinal tract, leading to enhanced oral bioavailability and increased therapeutic effect of the loaded drugs. Therefore, the present study aims to evaluate the anti-inflammatory activity of piroxicam-loaded SNEDDS as compared to conventional piroxicam suspension that was observed in male Wistar strain rats. The SNEDDS was tailored from a mixture of oleic acid, tween 80, and propylene glycol. Twenty male Wistar strain rats (aged 2-3 months, weighed 150-250g) were selected and were divided equally into 4 different groups receiving 1% PVP, SNEDDS carrier, piroxicam suspension (1.8 mg/Kg BW), and SNEDDS piroxicam (1.8 mg/Kg BW). Acute inflammation was induced by a carrageenan-induced paw edema model where the carrageenan was injected sub plantar in the hind paw of the rats to induce edema. Several parameters including paw edema volume, AUC0-6, and percent anti-inflammatory effect, were measured to evaluate the anti-inflammatory activity experienced in each group. At the end of this study, the piroxicam SNEDDS group significantly demonstrated better protection from paw edema compared to the piroxicam suspension group (Ï<0.05), suggesting that SNEDDS may enhance the anti-inflammatory activity of piroxicam.

Development of black cumin seed oil (Nigella sativa L.) SNEDDS into solid-SNEDDS and its characterization Rodhia Ulfa; Dwi Utami; Iis Wahyuningsih
Pharmaciana Vol 11, No 2 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Black cumin seed oil (MBJH) (Nigella sativa L.) is a well-known herb with pharmacology activities such as anticancer and anti-thrombocytopenia. The limitation of MBJH has poor absorption when using oral dosage form. The liquid SNEDDS (Self-nanoemulsifying drug delivery system) of MBJH as an alternative formulation. However, the disadvantage of liquid-SNEDDS of MJBH was the interaction between the active ingredients with soft gelatin capsules. Hence, this study proposed to develop solid-SNEDDS as a new formulation of MBJH. Solid-SNEDDS of MBJH was prepared from liquid-SEDDS of MBJH by adsorption to solid carrier method, consisting of aerosil and crospovidone as the adsorbent. The characterization of S-SNEDDS was determined by emulsification time and percentÂ transmittance. MicromeriticsÂ properties of S-SNEDDS such as the angle of repose, bulk and tap density parameter, compressibility index, and Hausner ratio were measured Â before and after stored in stress condition (40 ÌŠ C Â± 2 ÌŠ C and relative humidity of 75% Â± 5% for 14 days). The result showed S-SNEDDS of MBJH with aerosil absorbent had better S-SNEDDS performance in both characteristics and micromeritics properties under stress conditions than crospovidone absorbent. In conclusion, the s-SNEDDS of black cumin oil by solid aerosil carrier method is promising for future research development of S-SNEDDS dosage form.

EFEK ULCEROGENIC DISPERSI PADAT IBUPROFEN-POLIVINILPIROLIDON (PVP) PADA TIKUS PUTIH JANTAN Ririt Vita Febrianti; Iis Wahyuningsih
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

FORMULASI TABLET SERBUK PISANG RAJA (Musa xparadisiaca AAB) SEBAGAI PENUTUP TUKAK LAMBUNG PADA TIKUS Iis Wahyuningsih
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Co-Authors AA Sudharmawan, AA Adi Permadi Adi Permadi, Adi Ag. Yuswanto Aji Setya Bakti Alam, Samsul Anggreni, Nova Annas Binarjo Anwar, Shinta Desy Anwar, Shinta Desy Any Guntarti Any Guntarti Arif Budi Setianto Aty Widyawaruyanti Azis Ikhsanudin Bachri, Mochamad Saiful Bakti, Aji Setya Danang Prasetyaning Amukti Deasy Vanda Pertiwi Defita Sari Depprelia Wahyu Sutanti Depprelia Wahyu Sutanti Efiana, Nur Ari Ernidawati Erninda Ayu Hapsari Fadilah, Nur Aini Fauziyyah, Afifah Febrianika Ayu Kusumaningtyas Febrianti, Ririt Vita Fiftin Noviyanto Fiftin Noviyanto Firda Rahmadani Firda Rahmadani, Firda Fransisca, Indriyani Riski Fresiva, Urva Galang Pergiawan Ramadhan Gita Puspita Gustinanda, Rizky Handaningrum, Karunia Nining Hensi Setya Oktavia Hilma Putri Ibdal Satar Iin Narwanti Iin Narwanti Ikhsan Jaya Guntur Wicaksono Ilyas, Jenny Ima Dinny Rahmawaty Imam Riadi Indriyani Riski Fransisca Islamy, Muhammad Rido Islamy, Muhammad Rido Jenny Ilyas Kaffah, Silmi Khasnah, Nur khusnul khotimah Kurnia Ambarwati Kyllingga, Muhammad Rhapis Lasanudin, Rindi Ibrahim Lina Widiyastuti Magfirah Septiani Yusuf Maghfirah, Rahmayani Moch Saiful Bachri Muhammad Rido Islamy Muhammad Riski Pratama Muhammad Yusron Maulana El-Yunusi Narwanti, Iin Nazilah Shofi Risqina Nining Sugihartini Nining Sugihartini Nur Mahdi Nuri Ari Efiana Oci Widyastuti Oktavia, Hensi Setya Pelita, Putri Dina Pratama, Muhammad Riski Purwitasari, Neny Putri Dina Pelita Putri, Hilma Putri, Hilma Rahmawaty, Ima Dinny Rakhmawati, Kartika Rauhatun Napsah Reski Mulia Retno Widyowati Ririt Vita Febrianti Risqina, Nazilah Shofi Rodhia Ulfa Rohmiati Rohmiati Rohmiati, Rohmiati Rohmiati, Rohmiati Ronny Martien Ronny Martien Rustandi, Tedi Samsul Alam Sapto Yuliani Sapto Yuliani Sari, Defita Satar, Ibdal Sekar Prabawati Sembiring, Rinawati Shinta Desy Anwar Silviana Wulandari Sri Mulyaningsih Sri Mulyaningsih Sri Sulistyorini, Sri Srimuliani Arbie Sugiyanto - Sugiyanto Sugiyanto Sukardiman Sutanti, Depprelia Wahyu Tedy Setiadi Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wahyuningtyas, Winda Wicaksono, Ikhsan Jaya Guntur Widyasari Putranti Widyastuti, Oci Winda Wahyuningtyas Wiwied Ekasari Wulandari, Silviana Wulandari, Silviana Yenni Latief Yudha Rizky Nuari Yunda Maymanah Rahmadewi Yunda Maymanah Rahmadewi Yuswanto, Ag

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