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All Journal Pharmaciana: Jurnal Kefarmasian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Belitung Nursing Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Respirologi Indonesia Jurnal Ilmu Kefarmasian Indonesia Indonesian Journal of Cancer Eduvest - Journal of Universal Studies Jurnal Farmasi Indonesia Holistik Jurnal Kesehatan Jurnal Info Kesehatan Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Nadia Farhanah Syafhan
Division Of Clinical Pharmacy, Faculty Of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia | Universitas Indonesia Hospital, Jl. Prof. DR. Bahder Djohan, Pondok Cina, Beji, Depok, West Java 16424, Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Pharmaciana: Jurnal Kefarmasian

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Assessment of medication-related liver and kidney impairment in admitted patients in Depok, Indonesia: an observational study employing the Naranjo algorithm Syafhan, Nadia Farhanah; Aldora, Ghea Shafa; Kamila, Shinta
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.29012

Abstract

Liver and kidney impairment caused by medications represents serious side effects that may extend hospital stays and increase the risk of patient death. Implementing strategies to recognize, document, and analyze cases of patient harm related to drug use is crucial for medicines optimization. This study aimed to evaluate the prevalence of medication-related liver and kidney impairment among hospitalized patients, while also identifying the specific medication categories implicated. A retrospective review of patient records was conducted at Universitas Indonesia Hospital (Depok, Indonesia), focusing on adult patients diagnosed with liver or kidney impairment during their 2021 hospital admission. The Naranjo algorithm was applied to assess the likelihood that these injuries were caused by medications. Among the 4,273 admitted patients, it was found that 1.01% experienced medication-related liver impairment (MRLI), while 0.77% experienced medication-related kidney impairment (MRKI). The most common medications associated with liver impairment were antibiotics (31.58%), cardiovascular medications (24.21%), pain relievers (14.74%), anti-ulcer medications (11.58%), antiviral medications (8.42%), antiemetics (8.42%), and antidiabetic medications (1.05%). In contrast, kidney disease was primarily linked to diuretics (29.76%), antibiotics (21.43%), ACE inhibitors/ARBs (21.43%), antiviral medications (9.52%), and NSAIDs (7.14%). Importantly, there was no statistically significant correlation between the occurrence of MRLI or MRKI and factors such as gender, age, body mass index (BMI), or the presence of other health conditions (p > 0.05). These findings underscore the need for heightened awareness regarding the potential for medication-related impairments in hospitalized patients and suggest that careful monitoring of medication use is essential to mitigate these risks.
Co-Authors Abu Rachman Adil khan, Muhammad Aditya Wirawan Adityo Susilo, Adityo AGUSDINI BANUN SAPTANINGSIH Aldora, Ghea Shafa Amarila Malik Andi Utari Prasetya Ningrum Andrajati, Retnosari Ariesa Oktamauri Aziz, Muhammad Luthfi Azizahwati Bambang Karsono Bambang Wispriyono Candra, Tifany Maulida Chairunnisa, Dian Fitri Deli Marteka Delila Eliza DENNI JOKO PURWANTO, DENNI JOKO Dinda Bestari Sutantoputri Djuria, Rachmawati Felani Eliza, Delila Elsa Vera Denida Purba Farmasita Budiastuti, Rizky Fauzi, Muhamad Andhika Fauziyyah, Afina Nur Habibie, Taufan Harun Hadijah Tahir Hadiwati, Rangkay Hindun Wilda Risni Imaniar, Rania Imanuel Sianipar Ingrid Faustine July Kamila, Shinta Kartika Citra Dewi Permata Sari Kurniasih, Fransisca Dhani Kusumawardani, Larasati Arrum Maria, Nisa Meiliani Shara Suria L MUTIARA JEANY RAHAYU PERTIWI Nadhila Hasna Hanifah Nasution, Izza Aulia Rizqika Noor, Sidra Permata Sari, Kartika Citra Dewi Prasetyaningrum, Marchen Pukovisa Prawiroharjo Pukovisa Prawiroharjo, Pukovisa Purnama Putri, Raden Jacinda Yasmin Rachman, Abu Rachmawati Felani Djuria Rani Sauriasari Rani Sauriasari Rani Sauriasari, Rani Retnosari Andrajati Retnosari Andrajati Retnosari Andrajati Retnosari Andrajati Retnosari Andrajati Retnosari Andrajati Risni, Hindun Wilda Salsabila, Azzahra Fahira Santi Purna Sari Sri Wulandah Fitriani Sri Wulandah Fitriani Sri Wulandah Fitriani, Sri Wulandah Thoriq, Syahrul Fath Vriona Ade Maenkar Wahono, Dwi Edi Yahdiana Harahap