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All Journal Jurnal Gizi dan Pangan Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Nexus Biomedika Nexus Kedokteran Translasional Jurnal Media Gizi Indonesia (MGI) MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Jurnal Gizi dan Kesehatan Universa Medicina Paediatrica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Ilmu Gizi Indonesia Indonesian Journal of Medicine Jurnal Aisyah : Jurnal Ilmu Kesehatan Nusantara Science and Technology Proceedings PROFESI (Profesional Islam): Media Publikasi Penelitian Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Prosiding University Research Colloquium The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Advanced Technology and Multidiscipline (JATM)
Brian Wasita
Fakultas Kedokteran, Universitas Sebelas Maret
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Jurnal Aisyah : Jurnal Ilmu Kesehatan

 1 
Clinical Manifestations and Behavior Changes in Rats Treated with Jamaican Cherries Extract (Muntingia calabura) Afdhaliya, Noor Khalwati; Indarto, Dono; Wasita, Brian
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (680.65 KB) | DOI: 10.30604/jika.v7i1.878

Abstract

Iron deficiency anemia (IDA) in female adolescents is one of the health problems, which occupied 8th position as a cause of global disability and is the main cause of anemia in reproductive women. Iron tablet supplementation is the government program to reduce IDA prevalence in Indonesia but often results in gastrointestinal side effects. Jamaican cherries fruits contain vitamin C, iron and flavonoids, which play essential roles in iron metabolism. This study aimed to investigate the effects of Jamaican cherries fruits ethanol extract on clinical manifestations and behavior changes in female Wistar rats. This randomized controlled trial with pre-posttest control group design used 24 female Wistar rats, aged 10 -12 weeks and were randomly divided into 6 groups: N, positive control (PC: AIN-93M low iron food + elemental iron) and treatments (T1-4: AIN-93M low iron food + 0.26, 0.35, 0,5 or 0.75g/ 100g Body Weight (BW) Jamaican cherries fruits extract respectively for 28 days). Clinical manifestations, reflexes and behavior changes were observed at day 0, 14 and 28 interventions. BW data were analyzed using one way ANOVA and repeated measures ANOVA tests. All rats had normal reflexes and did not show clinical manifestations and behavior changes. The average of rat BW in T1-4 groups did not significantly differ before (p=0.896), during (p=0.884) and after treatment (p=0.775) but the average of rat BW in the T1 group increased significantly (p=0.012). In conclusion, administering Jamaican cherries fruits ethanol extracts up to 0.75g/100g BW has no toxic effects in female Wistar rats.  Abstrak: Anemia defisiensi besi (ADB) pada remaja putri merupakan salah satu masalah kesehatan yang menempati posisi ke-8 sebagai penyebab disabilitas tingkat global dan penyebab utama anemia pada ibu hamil. Suplementasi tablet besi merupakan program pemerintah untuk mengurangi prevalensi ADB di Indonesia tetapi sering menimbulkan efek samping di saluran percernaan. Buah kersen mengandung vitamin C, zat besi dan flavonoids yang berperan penting dalam metabolisme besi. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak buah kersen terhadap manifestasi klinis dan perubahan perilaku tikus Wistar betina. Penelitian randomized controlled trial ini dengan pre-posttest control group design dengan menggunakan 24 ekor tikus Wistar betina umur 10 -12 minggu dan dibagi secara acak menjadi 6 kelompok: normal, kontrol posistif (KP) dan perlakuan (P1-4). Tikus di KP diberi pakan AIN-93M dengan besi rendah + besi elemental sedangkan P1-4 diberi pakan yang sama ditambah 0.26, 0.35g, 0,5g atau 0.75g/100g berat badan (BB) secara berturut-turut ekstrak buah kersen selama 28 hari. Manifestasi klinis, reflek dan perubahan perilaku tikus diamati pada hari ke-0, 14 dan 28. Data BB dianalisis menggunakan uji one way ANOVA dan uji repeated measures ANOVA. Semua tikus memiliki reflek yang normal dan tidak menunjukkan manifestasi klinis dan perubahan perilaku. Rerata BB tikus pada P1-4 tidak berbeda signifikan sebelum (p=0,896), selama (p=0,884), maupun setelah perlakuan (p=0,775) tetapi rerata BB tikus P1 meningkat secara signifikan (p=0,012). Kesimpulan, pemberian ekstrak buah kersen hingga 0,75g/100g BB tidak menyebabkan toksisistas tikus Wistar betina.
Effects of Ambon Banana Juice on Glucose Levels and Lipid Profile in Diabetic Rats Herviana, Herviana; Indarto, Dono; Wasita, Brian
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1192.219 KB) | DOI: 10.30604/jika.v7i1.844

Abstract

Consumption of fruit juice is an alternative for diabetic patients who cannot consume fresh. Banana is one of the recommended fruits for diabetic patients because it has flavonoid content. This study aims to evaluate the effect of Ambon banana juice on fasting blood glucose (FBG), triglycerides, and total cholesterol levels in diabetic Wistar rats. The type of research is an experimental laboratory study with a pre-posttest design. The research sample was 21 male Wistar rats divided into 3 groups, T1 (control), T2 (10% fructose), and T3 (4 ml of Ambon banana juice) which were administered for 21 days. The FBG, triglycerides, and total cholesterol levels were examined using the colourimetric enzymatic method. The data were analyzed using one-way ANOVA, and post hoc tests. Ambon banana juice can improve FBG levels compared to control (p less than 0.01). Ambon banana juice can increase triglyceride levels but is significantly different from T2 (p less than 0.01). Ambon banana juice did not significantly increase total cholesterol levels compared to T2 (p less than 0.01). In conclusion, Ambon banana juice was demonstrated to decrease FBG and did not increase triglyceride and total cholesterol levels.Konsumsi jus buah merupakan alternatif bagi penderita diabetes yang tidak dapat mengkonsumsi buah segar. Pisang termasuk jenis buah yang direkomendasikan penderita diabetes, karena memiliki senyawa flavonoid. Tujuan penelitian ini untuk mengevaluasi efek jus pisang Ambon terhadap glukosa darah puasa (GDP), kadar trigliserida dan kolesterol total pada tikus diabetes. Jenis penelitian yaitu eksperimental laboratorik dengan desain pre-post test. Sampel penelitian berjumlah 21 ekor wistar jantan yang dibagi dalam 3 kelompok, T1 (kontrol), T2 (10% fruktosa), dan T3 (4ml jus pisang Ambon) yang diberikan selama 21 hari. Kadar GDP, trigliserida dan kolesterol total diukur menggunakan metode kolorimetri enzimatik. Data dianalisis menggunakan one-way ANOVA dan tes post hoc. Jus pisang ambon dapat membantu menurunkan kadar GDP dibanding kontrol (p kurang dari 0,01). Jus pisang Ambon dapat meningkatkan kadar trigliserida tetapi signifikan berbeda dibanding T2 (p kurang dari 0,01). Jus pisang ambon tidak signifikan meningkatkan kadar kolesterol total dibanding T2 (p kurang dari 0,01). Oleh karena itu, jus pisang ambon dapat membantu menurunkan kadar GDP dan tidak meningkatkan kadar trigliserida dan kolesterol total.
Co-Authors Adi Magna, Adi Adi Prayitno Afdhaliya, Noor Khalwati Agus Kristiyanto Amarduan, Tince Bety Amilia Yuni Damayanti Ana Rima Asrial, An A. Bambang Purwanto Binti Maulina Budiningsih, Fatichati Budiyanti Wiboworini Cindikya Saftiari Dewi Cr. Siti Utari Cr. SitiUtari Darmayani, Aritantri David Perdana Dentiko Wasis Aulia Dewi Okta Anggraini Diana Nurrohima Didik Prasetyo Diffah Hanim Dono Indarto Dyonisa Nasirochmi Pakha ernawati, ammik Eti Poncorini Pamungkasari Fadila, F Fakurazi, Shariza Gardjito, Fajar Baskoro Gunawan, Timotheus A. Hari Wujoso Harsono Salimo Hermansyah, Muhamad Lukman Herviana, Herviana Ida Nurwati Idulhaq, Mujaddid Irma Suryani Jati, Agus Kusumaningrum, Sulistyani Laqif, Abdurrahman LAWEI, THARINA Marintan, Elita Muchamad Syamsulhadi, Muchamad Muhammad Riza Muthmainah Muthmainah Muthmainah Nanang Wiyono Nofia, Yasinta Nur Shani Meida Nursulistyo, Fajar Paramasari Dirgahayu Paulus Kusnanto Pesik, Riza N. Poncorini, Eti Pudjiastuti, Anggit puguh santoso, puguh Rachmi Fauziah Rahayu Rahayu, Rachmi F. Rahmah Rahmah Ratih Puspita Febrinasari Reviono Reviono Risya Cilmiaty, Risya Riza Deviana Riza Novierta Pesik Sabariyah, Lely Santi, Nur Saputra, Rhyan Darma Senyum Indrakila Setianto, Budi Y. Soestrisno, Soestrisno Soetrisno Soetrisno Soetrisno Suyatmi Suyatmi Tamaulina Br Sembiring Taufiqurrahman, Surya Tedjo Danudjo Tonang Dwi Ardyanto Tri Harsono Tri Nugraha Susilawati Triyanta Yuli Pramana Umi Mahmudah Vitri Widyaningsih Wardhani, Lusi O. Wayanshakty, Janur Wulandari, Eka T. Wulansari, Indry Yarsa, Kristanto Y. Yudhani, Ratih D. Yudhani, Ratih Dewi Yundari, Yundari yusari Yusup Subagio Yusup Subagio Sutanto Zahidah, Fairuz Zaidah, Lailatuz