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All Journal International Journal of Electrical and Computer Engineering Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences The Journal of Experimental Life Sciences (JELS) Biotropika Proceeding International Conference on Global Resource Conservation The Journal of Pure and Applied Chemistry Research Majalah Obat Tradisional Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences
Nashi Widodo
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : Majalah Obat Tradisional

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Determination of Anticancer from EtOAc Fraction of Spatholobus Littoralis Hassk and of Molecular Structure Prediction Iskandar, Dodi; Widodo, Nashi; Warsito, Warsito; Masruri, Masruri; Rollando, Rollando; Afthoni, Muhammad Hilmi; Ichsan, Ichsan; Hermansyah, Adi
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.88894

Abstract

In recent years, the search for new anticancer drugs from local plants in Indonesia has become an interesting topic for research. One of the typical Indonesian local plants that have been used by the community as an anticancer traditional medicine (jamu) is Spatholobus littoralis Hassk (SLH) or better known as Bajakah. The native Dayak people of Kalimantan have used it for years for the treatment of breast cancer. In this study, the separation of single compounds from the ethyl acetate fraction of SLH stems was carried out, their molecular structure was analyzed, and anticancer bioactivity was tested. The isolation used the preparative HPLC method. The elucidation of the isolates from the ethyl acetat fraction used LCMS-MS, FTIR, and NMR. Anticancer bioactivity was determined using the MTT bioassay. The result is the acquisition of two isolates; it has been predicted that both are pseudobaptinin. The anticancer IC50 of the pseudobaptinin was 62.85 ppm, and Pseudobaptinin with impurities was 145.60 ppm.
Co-Authors Achmad Ridok Adi Hermansyah, Adi Agatha Mia Puspitasari Agatha Mia Puspitasari Annisa, Yuslinda Aris Soewondo Azerlyn, Defiona Rensia Naomi Custer C. Deocaris Deocaris, Custer C. Dewi Mustikaningtyas Didik Priyandoko Didik Priyandoko Dinia Rizqi Dwijayanti Dodi Iskandar, Dodi Dwi Adi Nugroho Fairuz Sarah Kamila Fitria Eka Aprilia Grahadi, Rahmat Hafil Kusuma, Kavana Hermanto, Feri Eko Ichsan Ichsan Ika Christina, Yuyun Ikhtiarini, Nur Inggita Kusumastuty Johan Aloysius Kamila, Fairuz Sarah Kaul, Sunil C. Kesuma, Suryanata Kholilah, Tsaniyah Nur Kusuma, Kavana Hafil Listijani Suhargo, Listijani Mariyah Ulfa, Siti Marlita Marlita, Marlita Masruri Masruri Mifetika Lukitasari Moch Sasmito Djati Mohammad Saifur Rohman Nafisah, Wirdatun Nia Kurniawan Nur Ida Panca Nugrahini Oktavia Rahayu Adianingsih Puspitarini, Sapti raudatul jannah raudatul jannah Renu Wadhwa Rifa'i, Muhaimin Rifa’i, Muhaimin Rizqi Dwijayanti, Dinia Rohmah, Ilmiana Nurur Rollando, Rollando Rosyadah, Nuraini Roudlotul Jannah ROUDLOTUL JANNAH Salma Wahid Marseti Siti Fatiyatur Rahmah Siti Fatiyatur Rahmah Siti Mariyah Ulfa Siti Nurkasanah Sri Winarsih Sunil C. Kaul Sutiman B. Sumitro VALENTINA YURINA Wadhwa, Renu Warsito Warsito Wayan Firdaus Mahmudy Widekdo, Dwi purno Widyananda, Muhammad Hermawan YOGA DWI JATMIKO Yuslinda Annisa Yuyun Ika Christina