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All Journal PROSIDING SEMINAR NASIONAL Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Human Nutrition Indonesian Journal of Biotechnology Sari Pediatri Paediatrica Indonesiana Media Ilmu Kesehatan Jurnal Kesehatan Madani Medika

Yati Soenarto

Department Of Child Health, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada, Yogyakarta, Central Java

Author-ID : 422551

Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Severity and treatment level of acute gastroenteritis with rotavirus in children under 5 years in INDONESIA Fatma Othman Gdara; Jarir At Thobari; Yati Soenarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Rotavirus diarrhea causing gastroenteritis in children under five years is an importantissue that urgently needs to be addressed globally. Delay in management of rotavirusdiarrhea can be fatal. Diagnostic tool for detecting rotavirus is, therefore, needed.However, until now the gold standard diagnostic tools are expensive, often not availableand affordable in health care settings. The aim of the study was to compare the Vesikariclinical severity score of rotavirus-positive with rotavirus-negative in hospitalized childrenwith acute gastroenteritis. Furthermore, the difference of the level of treatment betweenrotavirus-positive with rotavirus-negative was also evaluated. This was a cross sectionalstudy that using secondary data from medical records of five general teaching hospital inIndonesia. Subjects were children aged <5 years with acute watery diarrhea admitted tothe hospital. Statistical analysis used was chi square test, U-Mann Whitney, and KruskalWallis. The results showed that the patient with rotavirus positive have higher dehydration(80.2%) compared to rotavirus negative (70%). The severity level of clinical feature washigher in diarrhea due to rotavirus positive than non rotavirus (11.47± 2.89 vs 10.41± 2.70; p<0.000). The level of treatment was higher in rotavirus positive. The majorityhad treatment plan C (47.7%) higher than plan B and A (45.6% and 30.9%; p<0.050).This was opposite with patient with rotavirus negative that majority had treatment inplan A (69.1%) higher than plan B and C (54.4% and 52.3%) (p<0.001). In conclusion,the severity of gastroentrities in children under 5 years using vesikari score are higher indiarrhea due to rotavirus positive than non rotavirus. The treatment level plan C is higherthan plan B and A in diarrhea due to rotavirus. This is opposite with non rotavirus majorityhave treatment in plan A higher than plan B and C.

Trends of Rotavirus Diarrhea in Hospitalized Children in Yogyakarta Year 2013 –2015 Nenny Sri Mulyani; Dian Anggraini; Retno Palupi Baroto; Asal Wahyuni Erlin Mulyadi; Rizki Anindita; Yati Soenarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Diarrhea, together with pneumonia, is accountable for 25% death of children under five globally (IVAC, 2017). In Indonesia, diarrhea is also among the top ten diseases of cause of death in children under five (WHO, 2015). Rotavirus diarrhea is responsible for 60% in 2006 (Soenarto et al, 2009) of children diarrhea in Indonesia. Rotavirus vaccine in Indonesia was introduced commercially in 2011, nonetheless its use was reportedly low. Despite the declining rate of rotavirus incidence, surveillance is important to show the burden of rotavirus diarrhea in children. Thus, this study aims to describe the incidence of rotavirus diarrhea in hospitalized children under five in Yogyakarta province. This was a prospective study, conducted in two participating hospitals in Yogyakarta: RSUP Sardjito Yogyakarta and RSUD Wates from January 2013 – December 2015. This study is a part of the Indonesia surveilance entitled “Hospital-based surveillance of rotavirus diarrhea in children in Indonesia”, enrolling children under five hospitalized due to acute watery diarrhea. The questionare was modified from the WHO generic protocol of rotavirus surveillance (WHO, 2002). Data collection was perfomed after informed consent was signed by parent or guardian. The stool samples were tested for rotavirus with the EIA test and tested for genotyping with RT-PCR. The data were analysed and presented using descriptive analytic method. Of 684 eligible patients hospitalized with acute watery diarrhea, 557 subjects were enrolled with 518 feces were tested for rotavirus. The percentage of rotavirus incidence in year 2013, 2014, and 2015 were 37%, 41% and 61 % respectively. The predominant rotavirus genotyping was G3P [8]. Rotavirus mostly found in children age 6 – 23 months (55 %), and was identified more in male than female (62 % vs 38%). During the 3 years study period, rotavirus occurred all year round, and showed to reach its peak on January 2015. Rotavirus positive diarrhea commonly presented with dehydration (79%) compare to negative rotavirus diarrhea (55%). It indicated that the incidence rate of rotavirus diarrhea in Yogyakarta is quite high and rotavirus diarrhea remains as significant contributor to hospitalized children with diarrhea. The trend of rotavirus diarrhea in children under 5 years increased over the years’ period. The rotavirus diarrhea mostly presented with dehydration, thus rotavirus diarrhea remains as significant contributor to hospitalized children with diarrhea. This shows an evidence that the burden of rotavirus diarrhea in children under 5 years remains prominent.

Co-Authors Abdul Wahab Abu Tholib Aman Achirul Bakrie Achmad Suryono Agus Firmansyah Anak Agung Gede Sugianthara Anis Fuad Ari Dwi Ratna Kusumaningrum Asal Wahyuni Erlin Mulyadi Badriul Hegar Budi Susatyo Chatidjah Alaydrus Dian Anggraini Dwi Prasetyo Endy Paryanto Prawirohartono, Endy Paryanto Eva Putri Arfiani Fatma Othman Gdara Fitri Haryanti Hafni Soesilo Hafni Z. Soesilo Hamam Hadi Hannah Hannah Hera Nirwati Herman Herman Huryati, Emy Hutasoit, Masta I Nyoman Budi Hartawan I Putu Gede Karyana I wayan Sukardi I. K. G. Suandi Iesje Martiza Ignasia Nila Siwi Imanuel Y. Malino indah kartika Ismangoen Ismangoen Ismangoen Ismangoen Ismangoen Ismangoen Jarir At Thobari Karmini M Karyadi D Laksono Trisnantoro M Hakimi M P Damanik M. Juffrie M. P. Damanik Made Gede Dwi Lingga Utama Made Ratna Dewi Marlina, Yessi Moenginah P. A. Mohammad Juffrie Muhammad Suryanto Musta ida Muzal Kadim Nenny S Mulyani Nenny Sri Mulyani Ova Emilia Palupi, Astya Patricia Suti Lasmani Ramzi Ramzi Renny Hariati Retno Palupi Baroto Ristanto Ristanto Rizki Anindita Siswanto Marudut Soelistyowati S. Soelistyowati Soelistyowati Soetjiningsih Soetjiningsih Sudigbia I Suharyanto Supardi Sulistyowati Sulistyowati Sumadiono Sumadiono Sunartini Iman Sunartini Sunartini Susetyowati Thermiany Anggri Sundari Titis Widowati Titis Widowati Tri Wibawa Wasaraka, Yulia Nuradha Kartosiana Wayan Sukardi Wayan Sulaksmana Sandhi Parwata Widiarto Widiarto Widiatmodjo Widiatmodjo Widiatmodjo Widiatmodjo Widiyandana Widiyandana, Widiyandana Wiliam Jayadi Iskandar Yundari, Yundari

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