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All Journal HAYATI Journal of Biosciences Natural Science: Journal of Science and Technology Media Eksakta Indonesian Journal of Pharmaceutical Science and Technology Biocelebes Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Jurnal Health Sains Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Journal of Noncommunicable Diseases (JOND) Dedication : Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Medika: Medika Jurnal Pengabdian Farmasi dan Sains Journal of Tropical Pharmacy and Chemistry Jurnal Dedikatif Kesehatan Masyarakat Poltekita: Jurnal Pengabdian Masyarakat
Yuliet Yuliet
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Tadulako University, Jl. Sukarno-Hatta Km 9, Palu 94148, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
In Vitro And in Vivo Antidiabetic Activity of Ethanol Extract and Fractions of Hibiscus surattensis L Leaves Yuliet, Yuliet; Sukandar, Elin Yulinah; Adnyana, I Ketut
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.099 KB) | DOI: 10.15416/ijpst.v1i1.16120

Abstract

Hisbiscus surattensis L the local name “tamoenju” is utilized by ethnic Sumari (Central Sulawesi) as an antidiabetic herbal, but de nitive studies on ef cacy and safety are lacking. Therefore, this study was aimed to investigate the antidiabetic activity of ethanolic extract of the leaves and fractions using in vitro and in vivo models. Ethanol extract (EE) of the leaves of H. surattensis L was prepared by maceration. The ethanol extract was separated into three fractions by liquid/liquid extractions to yield n-hexane (HF), ethyl acetate (EAF) and water fraction (WF). Firstly, the extract and fractions were tested for its inhibitory activity on α-glucosidase in vitro. The results showed IC50 EE, HF and WF more than 5000 ppm while the IC50 fraction of EAF 3888.34 ppm. Then, oral glucose tolerance test (OGTT) of the extract/fractions were carried out in normal mice. On OGTT, the ethanol extract, EAF, and WF at doses of 150 and 300 mg/kg BW were able to inhibit increasing the level of glucose in the blood. The results showed that the extract and fraction of H. surattensis L leaves in vitro had no effect as α-glucosidase inhibitor but in vivo had the hypoglycemic effect especially on the fraction of ethyl acetate and the water fraction. Key words: α-glucosidase, antidiabetic, Hibiscus suratttensis, glucose tolerance.
In Vitro And in Vivo Antidiabetic Activity of Ethanol Extract and Fractions of Hibiscus surattensis L Leaves Yuliet Yuliet; Elin Yulinah Sukandar; I Ketut Adnyana
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.099 KB) | DOI: 10.24198/ijpst.v1i1.16120

Abstract

Hisbiscus surattensis L the local name “tamoenju” is utilized by ethnic Sumari (Central Sulawesi) as an antidiabetic herbal, but de nitive studies on ef cacy and safety are lacking. Therefore, this study was aimed to investigate the antidiabetic activity of ethanolic extract of the leaves and fractions using in vitro and in vivo models. Ethanol extract (EE) of the leaves of H. surattensis L was prepared by maceration. The ethanol extract was separated into three fractions by liquid/liquid extractions to yield n-hexane (HF), ethyl acetate (EAF) and water fraction (WF). Firstly, the extract and fractions were tested for its inhibitory activity on α-glucosidase in vitro. The results showed IC50 EE, HF and WF more than 5000 ppm while the IC50 fraction of EAF 3888.34 ppm. Then, oral glucose tolerance test (OGTT) of the extract/fractions were carried out in normal mice. On OGTT, the ethanol extract, EAF, and WF at doses of 150 and 300 mg/kg BW were able to inhibit increasing the level of glucose in the blood. The results showed that the extract and fraction of H. surattensis L leaves in vitro had no effect as α-glucosidase inhibitor but in vivo had the hypoglycemic effect especially on the fraction of ethyl acetate and the water fraction. Key words: α-glucosidase, antidiabetic, Hibiscus suratttensis, glucose tolerance.
Gastroprotective Effect of Ethanol Stem Bark Extract of Pepolo (Bischofia javanica Blume) Against Aspirin-Induced in Wistar Rat Yuliet Susanto; Rini Saputri; Khildah Khaerati
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 3 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i3.35452

Abstract

Prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) can trigger ulcers and bleed in the gastric mucosa. Pepolo stem bark (Bischofia javanica Blume) was a traditional plant that has been empirically used to treat gastric ulcers. This plant contains secondary metabolites such as alkaloids, flavonoids, tannins, saponins, and triterpenoids with gastroprotective potential. This study aims to determine the gastroprotective effect of pepolo stem bark extract (PSBE) against gastric ulcers of Wistar rat induced by Aspirin. The study used 24 rats grouped into six groups. Aspirin (150 mg/kg BW) was administered orally to all the groups except normal control. After 4 h of induction, normal and negative control received Na CMC 0.5%, while the positive group received Omeprazole (3.6 mg/kg BW). The remaining low, middle, and high dose groups received PSBE (100, 200, and 300 mg/kg BW). The treatment was given orally for eight days. On the 9th day, the rats were dissected and tested on the stomach organs. The parameters measured were scores based on the severity of rat peptic ulcers, ulceration index, and percentage protection ratio. The scoring data were analyzed using the Kruskal-Wallis non-parametric test and post hoc the Mann-Whitney test. The administration of PSBE showed the ability to reduce the ulcer index and increase the percentage of ulcer inhibition significantly compared to the negative control (p<0.05). This study showed that PSBE could be a promising gastroprotective herbal medicine.Key words: Aspirin, pepolo stem bark, gastric ulcer
Cytotoxic Effects of Hibiscus surattensis L. Leaves Extracts on BSLT, MCF-7 and Hela Cells Susanto, Yuliet -
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.41525

Abstract

Hibiscus surattensis L. leaves have been known as a folk medicine. Several previous reports have shown several potential therapeutic effects, including antidiabetic, antibacterial, anti-diarrheal, analgesic, hepatoprotective, and antioxidant, but no toxicity study is similar to the current one. Therefore, it is necessary to investigate the cytotoxic effect of these commonly consumed medicinal leaves. This study aimed to investigate the cytotoxicity of Hibiscus surattensis L. leaves extract (HSL). The cytotoxic effect was determined through brine shrimp lethality bioassay (BSLT) and in vitro Presto Blue assay of MCF-7 and Hela cell.  HSL extract was obtained by maceration using 96% ethanol. The BSLT results showed that the HSL has LC50 value of 224.814 μg/mL. MTT assay results showed the IC50 value of the HSL extract on MCF-7 cells was 1419.83 μg/mL, and Hela cells were 2050.50 μg/mL. Based on the LC50 value that has been analyzed against HSL extract shows an LC50 value of less than 1000 μg/mL which can be concluded while having potential cytotoxic activity against experimental animal larvae of A. salina Leach. The results of the cytotoxic test with Presto Blue assay on two cancer cells used showed that the HSL extract was not toxic.
Co-Authors Abd. Rahman Razak Adetya Maryani Adisaputra, Arya Dibyo Agus Ritna Agustinus Widodo Agustinus Widodo Akhmad Khumaidi Alfia, Dhara Ali Djamhuri Alkaff, Firas F. Alkaff, Sylmina D. Amelia Rumi Amelia Rumi Amelia Rumi Andi Athira Masyta Andi Atirah Masyita Andi Atirah Masyita Andi Fadya Andrya B Andrya B Apriyanti Anastasia Arisca, Windhy Nur Ariza Abu Bakar Putri Armini Syamsidi Arwinda Alitsia Hasyim Asriani Hasanuddin Atirah Atirah Bustanul Arifin Cahyani, Rezki Cornelia Ayu Putri Darmayanti Dermiati T Dermiati T Devi Saputri Bahman Devyayu Prabaningsih DEWI RISMAYANTI Djaleha, Helena Fransisca Dwicahya, Bambang Dwinthasari Meilinda Azhari Elin Yulinah Sukandar Elin Yulinah Sukandar Ersamukti Rahmatullah Achmad Evi Sulastri FIRMANITA DWIMURTI Fitri Anggun Solehah Gina N. Putri Hamdani, Silviana Hardani, Muhammad Fakhrul Heni Purwitasari I Ketut Adnyana Ihwam Ihwan Ihwan Ihwan Iklima Indriani, Meri Feki Inggrid Yuliana Ingrid Faustine Ismail, Ihwan Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Joni Tandi Joni Tandi, Joni Jusri Nilawati Karmini Karmini Khaerati Khildah - Khildah Khaerati Khildah Khaerati Khildah Khaerati Khusnul Diana Khusnul Diana Kurniawan, Muh D. Lokong, Gladies Melinda Lutfiana Kusumawati Mariyani Marzelany M Sombolinggi Masyita, Andi Atirah Meike Rachmawati Mia Audina Moh. Roem Mohamad Ikram Muhamad Rinaldhi Tandah Muhammad Anggriawan Muhammad F. Haq Muhammad Fahrul Hardani Muhammad Fahrul Hardani Muhammad Sulaiman Zubair Muthi’ah H Z Nasrah Said Nela Sharon Ni Luh Rindiani Ni Made Susilawati Ni Wayan Swintari Nifien Mokuna Niluh Puspita Dewi Novalina Serdiati Nur Hikmah Nur Ramadhani Nurihardiyanti Nurihardiyanti Nurul Awwaliyah P. Firman Oryza Sativa Padmawati, Retna S. Perwitasari, Dyah A. Postma, Maarten J. Putri A. Arta R. Rokhman, Muhammad Ramadhanil Ramadhanil Rasuane Noor Rauf, Saidah Recky Patala Revina Triani Rhizky S Auliana Rini Saputri Ririen Hardani Ririen Hardani Ririen Ririen Ririn Hardani Ritha Pratiwi S. Malasugi Salamah, Sovia Shella Desiana Sinta Amelia Siti B. Al-Amri Sitti Kholidah Sri Indrawati Steffi Liem Sugeng, Santoso Sukmawati, Sukmawati Syahna Shaldan Syamsul Lakahoro Syaputra, Gunawan Syariful Anam Tirza Retno Kinasih Baginda Triana Riandani Djamhuri Tricia Andini Tunreng, Muh. Fadil Usman Umar, Miranti Wa Ode S. Musnina Yonelian Yuyun Yusriadi Yusriadi Zulkarnain Zulkarnain