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A Recent Update: Molecular Mechanism of Kombucha as A Probiotic for Obesity Management Nisa, Zulfia Rosyidatun; Jusup, Sinu Andhi; Yudhani, Ratih Dewi
Proceedings of the International Conference on Nursing and Health Sciences Vol 5 No 1 (2024): January-June 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v5i1.3820

The prevalence of obesity has continued to increase in the past decade which has an impact on several metabolic disorders in the body. Various efforts are made to reduce and overcome the effects of obesity such as pharmacological therapy. In addition, using natural ingredients such as probiotics is optimized to minimize the effects caused. The balance of gut microbiota has an important role in helping to improve dysbiosis, inflammation, and fatty liver in obesity. Method: This review used the scoping review necessary to collect and summarize scientific data as well as guide future investigations with the provision that articles are up to the last 10 years (2014) for kombucha as a drink rich in probiotics that could have potential as a natural therapy for obesity management. Results: A total of 244 articles were collected and 11 articles met the inclusion criteria. Conclusion: kombucha has beneficial effects and has the potential to improve obesity conditions from a variety of mechanisms.

Curcumin compounds and total microorganisms in turmeric kombucha as a potential therapy in rats obesity model Nisa', Zulfia Rosyidatun; Jusuf, Sinu Andhi; Yudhani, Ratih Dewi
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 13 ISSUE 2, 2025
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2025.13(2).114-124

ABSTRAKLatar belakang: Prevalensi obesitas meningkat signifikan dalam satu dekade terakhir dan berisiko menimbulkan berbagai komplikasi seperti diabetes melitus tipe 2, kardiovaskular, bahkan kanker. Terapi farmakologi obesitas seperti liraglutide dan orlistat dapat memberikan efek negatif pada tubuh seperti gangguan saluran pencernaan. Hal ini mendorong pengembangan terapi berbahan alami untuk obesitas. Kombucha dan kunyit kuning secara tunggal dilaporkan bersifat antioksidan dan mampu memperbaiki obesitas. Kombinasi kombucha kunyit kuning berpotensi dikembangkan sebagai minuman probiotik untuk obesitas karena senyawa bioaktif yang dikandungnya. Namun, eksplorasi fitokimia dan mikroorganisme pada turmeric kombucha masih sangat terbatas dan penelitian kombinasi kombucha kunyit kuning untuk obesitas belum pernah dilakukan sebelumnya.Tujuan: Mengeksplorasi kandungan fitokimia dan total mikroorganisme kombucha kunyit kuning dan kemampuannya untuk memperbaiki obesitas. Metode: Eksperimental laboratorik dengan rancangan pre-post control group dan deskriptif observasional. Analisis kurkumin menggunakan KLT Densitometri. Mikroorganisme dianalisis dengan metode pour plate kemudian dihitung berdasarkan total plate count. Tikus model obesitas diberikan tiga variasi dosis kombucha kunyit kuning selama 28 hari dan dilakukan penilaian perubahan indeks Lee yang diuji statistik menggunakan Kruskal Wallis (p<0.05) dan Post hoc Dunn Test. Hasil: Hasil penelitian menunjukkan kandungan kurkumin pada kombucha kunyit kuning sebesar 0,73 mg/L dan total mikroorganisme sebesar 2,60 x 107 CFU/ml. Kombucha kunyit kuning memperbaiki indeks Lee tikus model obesitas dibanding kontrol negatif (p<0.05) dengan dosis paling efektif sebesar 4,4 ml/200 g/hari (dosis tertinggi di penelitian ini). Kesimpulan: Kombucha kunyit kuning memiliki kandungan kurkumin dan manfaat mikoorganisme yang dapat memperbaiki indeks Lee pada tikus model obesitas. Kata Kunci: kombucha kunyit kuning; kurkumin; mikroorganisme; obesitas ABSTRACT Background: The prevalence of obesity has increased significantly in the last decade, raising the risk of complications such as type 2 diabetes, cardiovascular diseases, and even cancer. Pharmacological therapies for obesity, such as liraglutide and orlistat, can have negative effects on the body, including gastrointestinal disorders. This drives interest in the development of natural-based therapies for obesity. Kombucha and turmeric individually are known for their antioxidant properties and their ability to address obesity. The combination of turmeric kombucha has the potential to be developed as a probiotic drink for obesity due to the bioactive compounds it contains. However, research into the phytochemical profile and microorganisms in turmeric kombucha is still limited, and no studies have been conducted on the combination of turmeric kombucha for obesity treatment.Objectives: To explore the phytochemical content and total microorganisms in turmeric kombucha and to evaluate its potential in improving obesity treatment.Methods: Laboratory experiments were conducted with pre-post control group design and descriptive observational analysis. Curcumin levels were analysed using KLT Densitometry, while microorganisms were identified through the pour plate method and quantified via total plate count. Obese model rats received three different doses of turmeric kombucha over 28 days, and changes in their Lee index value were assessed and statistically analysed using Kruskal Wallis (p<0.05) and Post hoc Dunn Test. Results: The findings revealed that the curcumin concentration in turmeric kombucha was 0.73 mg/L and the total microorganisms were 2,60 x 107 CFU/ml. Kombucha yellow turmeric improved the Lee index of obese model rat compared to negative control (p<0.05) with the most effective dose being 4.4 ml/200 g/day (the highest dose in this study).Conclusions: Turmeric kombucha contains curcumin and beneficial microorganisms, which can improve the Lee index in obese model rats.Keywords: curcumin; obesity; microorganisms; turmeric kombucha Received: 17 Jan 2025; Revised: 20 Sep 2024; Accepted: 26 Jan 2025; Available online: 30 Mar 2025; Published: 30 Mar 2025

The Role of Interleukin 1β, Fibroblast Growth Factor, Fibroblasts, Keratinocytes, Granulation Tissue and Collagen Density in the Wound Healing Phase (Study of Wound Healing in the Inflammation, Proliferation, and Remodeling Phases) Christanto, Antonius; Cilmiaty, Risya; Setiamika, Made; Yudhani, Ratih Dewi; Dirgahayu, Paramasari; Pamungkasari, Eti Poncorini; Nurwati, Ida
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.399

This scoping review explores the roles of interleukin 1β, fibroblast growth factor, fibroblasts, keratinocytes, granulation tissue, and collagen density in the wound healing process, focusing on inflammation, proliferation, and remodeling phases. A systematic literature search identified studies investigating molecular and cellular mechanisms involved in wound repair. Findings reveal that fibroblast-derived exosomes carrying miR-93-5p inhibit autophagy, delaying diabetic wound healing. Controlled growth factor delivery enhances angiogenesis, fibroblast proliferation, and collagen deposition, accelerating tissue regeneration. SPRR1B+ keratinocytes facilitate rapid re-epithelialization, while granulation tissue provides essential scaffolding for cell migration and neovascularization. Elevated IL-1β impairs healing by increasing matrix metalloproteinases, degrading collagen. Natural compounds like red fruit oil and Binahong leaf extract promote angiogenesis and collagen synthesis. Genetic variations in inflammatory cytokines influence healing outcomes, indicating potential for personalized therapies. This review consolidates current evidence, providing insights into cellular and molecular interactions critical for effective wound repair and guiding future regenerative medicine strategies.

ANALYSIS OF BIOACTIVE COMPOUNDS POTENTIAL IN ETHANOL EXTRACT OF WATERMELONS (Citrullus lanatus) MESOCARP Fauziah, Melinda; Susanto, Agung; Yudhani, Ratih Dewi
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.3252

Semangka (Citrullus lanatus) merupakan buah tropis yang banyak dibudidayakan dan dikonsumsi di Indonesia. Namun, konsumsi masyarakat umumnya terbatas pada bagian daging buah, sedangkan mesokarp (lapisan putih antara kulit dan daging buah) sering kali dibuang sebagai limbah. Kondisi ini turut menyumbang peningkatan limbah organik dari sektor hortikultura yang belum dimanfaatkan secara optimal. Selain itu, mesokarp semangka diketahui mengandung senyawa bioaktif seperti flavonoid, fenolik, dan alkaloid yang memiliki aktivitas antioksidan, antiinflamasi, dan antidiabetik. Meskipun potensinya telah banyak dilaporkan, namun pemanfaatannya secara optimal dalam pengembangan agen terapi alami masih terbatas. Penelitian ini bertujuan untuk mengeksplorasi kandungan senyawa bioaktif dari ekstrak etanol mesokarp semangka dengan dua konsentrasi pelarut berbeda, yaitu etanol 70% dan etanol 96%, menggunakan metode maserasi. Desain penelitian yang digunakan berupa eksperimental laboratorik. Simplisia mesokarp semangka diekstraksi, kemudian dianalisis kadar total flavonoid, fenolik, dan alkaloid menggunakan metode spektrofotometri UV-Vis. Hasil menunjukkan rendemen pada etanol 70% sebesar 51.7%, lebih tinggi dibandingkan etanol 96% sebesar 44.65%. Kandungan flavonoid dan alkaloid lebih tinggi ditemukan pada ekstrak etanol 70% (masing-masing 4,01% dan 1438,03 µg/g), sementara kandungan fenolik lebih tinggi ditemukan pada etanol 96% (5,92%). Penelitian ini mengindikasikan bahwa pemilihan konsentrasi pelarut yang tepat sangat menentukan keberhasilan ekstraksi senyawa bioaktif dari mesokarp semangka, sehingga berpotensi dimanfaatkan sebagai bahan dasar dalam pengembangan agen antioksidan alami.

The Liver histopathology structure of Wistar rats on the acute toxicity test of Kapulaga Seeds extract (Amomum cardamomum) Ratih Dewi Yudhani; Rizka Hendriyani; Riza Novierta Pesik
Indonesian Journal of Pharmacology and Therapy Vol 1 No 2 (2020)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.717

One-third of the Indonesian population uses herbs for alternative medicine empirically. One of them is Kapulaga (Amomum cardamomum) which known as a spice and traditionally used for the treatment of rheumatic, fever, cough, sore throat, and mouth odor. The clinical use of herbs must be supported by scientific evidenced-based and its safety profile. The risk of exposure to a substance in humans can be identified through the toxicity tests on animals. The liver histopathological structure is one of the parameters of the acute toxicity test. This study to determine the acute toxicity of Kapulaga seeds extract (Amomum cardamomum) based on the liver histopathological structure of Wistar rats. The sample selection based on inclusion and exclusion criteria in the OECD 420 guideline. The research consisted of a preliminary and the main test. One rat was used in the preliminary test with an initial dose of cardamom seed extract 300 mg/kg BW and followed by a maximum dose of 2000 mg/kg BW after 48 hours. The main test used 10 rats that were randomly divided into control and treatment groups. Based on the result of the preliminary test, the treatment group was given a single dose of cardamom seed extract 2000mg /kg BW, whilst the control group was given distilled water. Observations of any toxic signs or dead were conducted every 30 minutes in the first 4 hours and continued once per day until 14thday. Assessment of the degree of liver damage was done using the liver damaged scoring and compared using the Mann Whitney test (α = 0.05). The average liver damage score of control and treatment groups is 0.96 ± 0,856 and 0.96 ± 0,604, respectively, and did not show any statistically significant differences (p>0,05). Kapulagaseeds (Amomum cardamomum) had no acute toxic effect based on the liver histopathological structure of Wistar rats.

Systematic Review: Peran Sel, Jaringan, dan Kolagen dalam Penyembuhan Perforasi Membran Timpani Antonius Christanto; Risya Cilmiaty; Made Setiamika; Ratih Dewi Yudhani; Paramasari Dirgahayu
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 4 No. 4 (2025): November 2025
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v4i4.5771

Tympanic membrane perforation is a significant clinical concern that can lead to hearing impairment and recurrent ear infections. This study aims to review the roles of Interleukin-1 beta (IL-1β), Fibroblast Growth Factor (FGF), fibroblasts, keratinocytes, granulation tissue, and collagen density during the wound-healing phases of the tympanic membrane.A Systematic Journal Review was conducted by analyzing studies retrieved from PubMed, Scopus, ScienceDirect, and Google Scholar databases published between 2020 and 2025. Of the 400 records screened,, 10 studies met the inclusion criteria. The findings revealed that IL-1β plays a key role in the inflammatory phase by modulating immune responses and recruiting healing cells. FGF stimulates fibroblast and keratinocyte proliferation, which are essential for extracellular matrix (ECM) remodeling and re-epithelialization. Moreover, granulation tissue formation and collagen deposition are critical determinants of structural integrity and healing quality. Overall, tympanic membrane repair requires synergistic interactions among molecular mediators, cellular components, and biomaterial support to optimize tissue regeneration. These findings provide a scientific basis for developing more effective regenerative and tissue-engineering strategies for middle ear therapy.

Curcumin compounds and total microorganisms in turmeric kombucha as a potential therapy in rats obesity model Nisa', Zulfia Rosyidatun; Jusuf, Sinu Andhi; Yudhani, Ratih Dewi
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 13 ISSUE 2, 2025
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2025.13(2).114-124

ABSTRAKLatar belakang: Prevalensi obesitas meningkat signifikan dalam satu dekade terakhir dan berisiko menimbulkan berbagai komplikasi seperti diabetes melitus tipe 2, kardiovaskular, bahkan kanker. Terapi farmakologi obesitas seperti liraglutide dan orlistat dapat memberikan efek negatif pada tubuh seperti gangguan saluran pencernaan. Hal ini mendorong pengembangan terapi berbahan alami untuk obesitas. Kombucha dan kunyit kuning secara tunggal dilaporkan bersifat antioksidan dan mampu memperbaiki obesitas. Kombinasi kombucha kunyit kuning berpotensi dikembangkan sebagai minuman probiotik untuk obesitas karena senyawa bioaktif yang dikandungnya. Namun, eksplorasi fitokimia dan mikroorganisme pada turmeric kombucha masih sangat terbatas dan penelitian kombinasi kombucha kunyit kuning untuk obesitas belum pernah dilakukan sebelumnya.Tujuan: Mengeksplorasi kandungan fitokimia dan total mikroorganisme kombucha kunyit kuning dan kemampuannya untuk memperbaiki obesitas. Metode: Eksperimental laboratorik dengan rancangan pre-post control group dan deskriptif observasional. Analisis kurkumin menggunakan KLT Densitometri. Mikroorganisme dianalisis dengan metode pour plate kemudian dihitung berdasarkan total plate count. Tikus model obesitas diberikan tiga variasi dosis kombucha kunyit kuning selama 28 hari dan dilakukan penilaian perubahan indeks Lee yang diuji statistik menggunakan Kruskal Wallis (p<0.05) dan Post hoc Dunn Test. Hasil: Hasil penelitian menunjukkan kandungan kurkumin pada kombucha kunyit kuning sebesar 0,73 mg/L dan total mikroorganisme sebesar 2,60 x 107 CFU/ml. Kombucha kunyit kuning memperbaiki indeks Lee tikus model obesitas dibanding kontrol negatif (p<0.05) dengan dosis paling efektif sebesar 4,4 ml/200 g/hari (dosis tertinggi di penelitian ini). Kesimpulan: Kombucha kunyit kuning memiliki kandungan kurkumin dan manfaat mikoorganisme yang dapat memperbaiki indeks Lee pada tikus model obesitas. Kata Kunci: kombucha kunyit kuning; kurkumin; mikroorganisme; obesitas ABSTRACT Background: The prevalence of obesity has increased significantly in the last decade, raising the risk of complications such as type 2 diabetes, cardiovascular diseases, and even cancer. Pharmacological therapies for obesity, such as liraglutide and orlistat, can have negative effects on the body, including gastrointestinal disorders. This drives interest in the development of natural-based therapies for obesity. Kombucha and turmeric individually are known for their antioxidant properties and their ability to address obesity. The combination of turmeric kombucha has the potential to be developed as a probiotic drink for obesity due to the bioactive compounds it contains. However, research into the phytochemical profile and microorganisms in turmeric kombucha is still limited, and no studies have been conducted on the combination of turmeric kombucha for obesity treatment.Objectives: To explore the phytochemical content and total microorganisms in turmeric kombucha and to evaluate its potential in improving obesity treatment.Methods: Laboratory experiments were conducted with pre-post control group design and descriptive observational analysis. Curcumin levels were analysed using KLT Densitometry, while microorganisms were identified through the pour plate method and quantified via total plate count. Obese model rats received three different doses of turmeric kombucha over 28 days, and changes in their Lee index value were assessed and statistically analysed using Kruskal Wallis (p<0.05) and Post hoc Dunn Test. Results: The findings revealed that the curcumin concentration in turmeric kombucha was 0.73 mg/L and the total microorganisms were 2,60 x 107 CFU/ml. Kombucha yellow turmeric improved the Lee index of obese model rat compared to negative control (p<0.05) with the most effective dose being 4.4 ml/200 g/day (the highest dose in this study).Conclusions: Turmeric kombucha contains curcumin and beneficial microorganisms, which can improve the Lee index in obese model rats.Keywords: curcumin; obesity; microorganisms; turmeric kombucha Received: 17 Jan 2025; Revised: 20 Sep 2024; Accepted: 26 Jan 2025; Available online: 30 Mar 2025; Published: 30 Mar 2025

Red Rice Bran Ethanol Extract Reduces IL-1β as the Risk of Pancreas Fibrogenesis in Type 2 Diabetic Rat Model Brian Wasita; Ratih Dewi Yudhani; Dyonisa Nasirochmi Pakha; Diana Nurrohima; Muthmainah Muthmainah; Nanang Wiyono; Shariza Fakurazi
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3410

BACKGROUND: Oxidative stress and inflammation contribute to pancreatic cell dysfunction that promote insulin resistance in type 2 diabetes (T2D). Red rice bran contains bioactive substances with anti-inflammatory and antioxidant properties which improved insulin resistance in obese mice. However, no studies have explored the potential of ethanol extract of red rice bran (EERRB) to prevent T2D progression, particularly pancreatic fibrosis complications. This study was conducted to investigate the effect of EERRB on inflammation measured with interleukin (IL)-1β and fibrosis of pancreatic tissue in a rat model of T2D. METHODS: Rats were induced with streptozotocin and nicotinamide to induce diabetes, and then separated into five groups. One group received no treatment, while the other four received 9 mg/kg/day acarbose, 165, 330, or 660 mg/kg/day EERRB orally for 21 days. Immunohistochemistry was conducted on pancreas tissues to measure the expression of IL-1β, while pancreatic fibrosis was assessed with Masson’s Trichrome staining.RESULTS: EERRB reduced the expression of pro-inflammatory cytokine, IL-1β, in pancreas tissue in a dose dependent manner. Significantly lower IL-1β expression were found in group receiving 660 mg/kg/day EERRB (10%) compared to diabetic with no treatment group (50%) (p<0.0001). Additionally, the IL-1β expression in the highest dose of EERRB group was comparable to the group receiving acarbose (10%). CONCLUSION: This finding suggests the beneficial effect of EERRB in the hyperglycemic condition that causes oxidative stress through blocking the IL-1β expression, hence alleviating the inflammation in pancreas tissue, and have a tendency in preventing pancreatic fibrosis progression, a process implicated in T2D pathogenesis. KEYWORDS: diabetes, inflammation, pancreatic fibrosis, red rice bran

Systematic Journal Review: Mechanical Durability Of L-PRF Organic Material At Body Temperature During The Wound Healing Phase (14 Days) Of Tympanic Membrane Perforation And Myringoplasty Surgery Christanto, Antonius; Cilmiaty, Risya; Setiamika, Made; Yudhani, Ratih Dewi; Dirgahayu, Paramasari; Pamungkasari, Eti Poncorini; Nurwati, Ida
PROMOTOR Vol. 9 No. 1 (2026): FEBRUARI
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/pro.v9i1.1741

The purpose of this study is to evaluate the viability and structural stability of L-PRF at 37°C over 14 days. It aims to determine its sustained growth factor release and potential effectiveness in regenerative clinical applications. This research employed a Systematic Journal Review (SJR) approach, surveying articles from databases such as PubMed, Scopus, and Google Scholar using specific keywords related to L-PRF. A total of 25 articles meeting the inclusion criteria were filtered for analysis. Furthermore, common experimental methods described in the literature include the preparation of L-PRF via blood centrifugation and viability testing over 14 days at 37°C, encompassing analysis of microscopic structure, mechanical properties, and biochemical and biological activities. Literature analysis indicates that L-PRF is an effective autologous biomaterial for regenerative applications, capable of continuously releasing growth factors such as PDGF, TGF-β, VEGF, and IGF for up to 14 days at body temperature. Cell viability within the fibrin matrix is maintained, positioning L-PRF as a promising active biological scaffold for accelerating tissue healing. Although challenges such as matrix degradation persist, modification strategies and optimized centrifugation protocols can enhance the effectiveness and durability of L-PRF in clinical applications.

Keunggulan L-PRF Dibandingkan P-PRF, PRFM, A-PRF, & I-PRF sebagai Cangkok pada Operasi Miringoplasti: Studi Penyembuhan Luka pada Perforasi Membran Timpani Antonius Christanto; Risya Cilmiaty; Made Setiamika; Ratih Dewi Yudhani; Paramasari Dirgahayu
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v5i1.6020

This study aims to analyze the advantages of Leukocyte-Platelet Rich Fibrin (L-PRF) application in myringoplasty surgery compared to other platelet concentrates such as Platelet-Rich Fibrin Membrane (PFRM), Advanced Platelet-Rich Fibrin (A-PRF), and Injectable Platelet-Rich Fibrin (I-PRF). The research method used is a qualitative literature review, collecting and analyzing data from recent scientific journals and clinical studies related to the use of L-PRF in tympanic membrane repair. The study finds that L-PRF, with its dense fibrin network and high content of leukocytes and growth factors, enhances tissue regeneration, angiogenesis, and epithelialization, which are critical for successful graft integration and faster healing after myringoplasty. Compared to other platelet concentrates, L-PRF offers better mechanical strength and a more sustained release of growth factors. Additionally, L-PRF reduces postoperative complications and improves hearing outcomes. Being an autologous biomaterial, it also reduces the risk of immune rejection. The findings suggest that L-PRF is a promising graft material in otologic surgery, though further clinical trials are needed to optimize its application protocols.

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