Skin aging is a natural process that manifests prominently in facial skin. Key indicators of facial skin aging include sagging skin, wrinkles, hyperpigmentation, and decreased hydration. Understanding these signs is crucial for both clinical and cosmetic applications. This review focuses on the skin microbiome, with a particular emphasis on Staphylococcus hominis, a commensal bacterium that plays a significant role in the skin aging process. The objective of this article is to consolidate scientific evidence from various studies to elucidate the relationship between the skin microbiome, especially S. hominis, and the manifestations of skin aging. Through this comprehensive review, we aim to provide insights into the potential of targeting the skin microbiome for anti-aging interventions and enhance our understanding of the complex interactions between skin health and its microbial inhabitants.