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SARONOM SILABAN
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Journal : Jurnal Bioteknologi

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ANTIDIABETIC ACTIVITY OF LEAF EXTRACT OF Clerodenrum fragrans Vent Willd IN Rattus novergicus INDUCED BY ALLOXAN Saronom Silaban
Jurnal Bioteknologi dan Biosains Indonesia Vol. 9 No. 1 (2022)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

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Abstract

Sarang banua plants are grown in Simalungun, North Sumatra, Indonesia, and have been used by the community as traditional medicinal plants. Sarang banua plant is a type of Clerodendrum fragrans Vent Willd, including the family Verbenaceae. This study aimed to determine the antidiabetic activity of the leaf extract of sarang banua (C. fragrans Vent Willd) in white male rats (Rattus novergicus) induced by alloxan. This study used a RAL design with seven treatments, namely (K0) standard feed, (K1) Na-CMC 0.5%), (K2) metformin, (K3) ethanol extract 100 mg/kg bw, 200 mg/kg bw (K4), 300 mg/kg bw (5), (K6) ethyl acetate extract 200 mg/kg bw and 300 mg/kg bw (K7). Groups K1 to K7 were induced by alloxan before being given treatment. Each treatment was replicated three times. The results showed that the application of leaf extract of the C. fragrans affected on reducing the blood glucose levels of alloxan-induced rats. The used of ethanolic extract of C. fragrans 100 mg/kg bw resulted in the highest percentage decrease in blood glucose (54.46 ± 5.60%) of hyperglycemic rats induced by alloxan, close to a positive control (56.63 ± 1.86%).
Co-Authors Adillah, Rani Albinus Silalahi Arfika, Nurul Asmi, Andalia Boangmanalu, Eka Putra Dairi Dede Ruslan DEDE RUSLAN Dodi Pramana Eddiyanto Eddiyanto Eka Putra Dairi Boangmanalu Ginting, Susanna Gurning, Biworo Frida Hariono Hariono Hesti Fibriasasi IMAN PERMANA MAKSUM IMAN PERMANA MAKSUM Juniastel Rajagukguk Khairani Islamiyah KHOMAINI HASAN Lenti Susanna Saragih Limbong, Rachel Wandira Lukman, Mena Fadillia Marudut Sinaga Murniaty Simorangkir Partomuan Simanjuntak Pohan, Ade Hermansyah Putri Novira Rajagukguk, Suryana Ramlan Silaban Ribu Surbakti, Ribu Saragih, Lenti Susanna Saragih, Martua Haojahan Setiawan, Mhd Arif SHABARNI GHAFFAR Siahaan, Sabda Dian Nurani Sibarani, Choms Gary Ganda Tua Siregar, Litani Siti Ulgari SOETIJOSO SOEMITRO Sriadhi Sriadhi, Sriadhi SUTARYA ENUS Tita Juwitaningsih Tonel Barus, Tonel Toto Subroto Ulgari, Siti Wirda Hayatina Lubis, Wirda Hayatina Yeni Purba, Fince Putri