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All Journal The Indonesian Biomedical Journal YARSI Medical Journal Jurnal Kefarmasian Indonesia
Putri Reno Intan
Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Public Health

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Journal : Jurnal Kefarmasian Indonesia

 1 
Ekstrak Daun Annona muricata Linn. sebagai Antiproliferasi terhadap Sel Hepar Tikus Terinduksi 7,12 Dimetilbenz [a] antracene (DMBA) Adelina, Rosa; Febriyanti, Rahmi; Oktoberia, Intan Sari; Intan, Putri Reno
Jurnal Kefarmasian Indonesia VOLUME 4. NOMOR 1 FEBRUARI 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v4i1.2896

Abstract

Annona muricata Linn. atau sirsak yang mengandung senyawa golongan acetogenin mampu menginduksi apoptosis pada secara in vitro dan bersifat sitotoksik. Telah dilakukan penelitian untuk membuktikan potensi ekstrak daun sirsak secara in vivo dalam menghambat perkembangan tumor hepar akibat induksi senyawa kimia 7,12 dimetilbenz [a] antracene (DMBA). Induksi dilakukan selama dua kali seminggu selama lima minggu, pada hewan coba tikus putih (Rattus novergicus) strain Sprague Dawley. Ekstrak daun sirsak diberikan dengan tiga peringkat dosis, yaitu 200, 400, dan 800 mg/kg BB, selama tujuh belas hari setelah dua minggu pemberian DMBA. Hasil pemeriksaan histopatologi dan penentuan aktivitas proliferasi sel hepar dengan AgNOR menunjukkan adanya penurunan aktivitas proliferasi sel hepar secara signifikan. Disimpulkan bahwa ekstrak daun sirsak berpotensi sebagai antiproliferasi pada tumor hepar secara in vivo.
Toksisitas Akut dan Subkronis Ramuan Ekstrak Kelor dan Klabet sebagai Pelancar ASI dan Penambah Gizi Widowati, Lucie; Winarno, M Wien; Intan, Putri Reno
Jurnal Kefarmasian Indonesia VOLUME 4, NOMOR 2, AGUSTUS 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Insufficient breast milk intake from a mother to their babies may cause a poor infant growth. We have conducted a research on mixture of klabet seed extracts (Trigonella foenum-graecum L.) and kelor leaf extract (Moringa oleifera Lamk.) (1:1) for increasing breast milk production in nursing mothers and nutritional supplement for infants. The study is a completely randomized design. We used white rats (Rattus novergicus), Wistar strain, as many as 50, that were divided into 5 dose groups for the acute toxicity testing and 40 rats in 4 dose groups for the sub-chronic toxicity testing.The acute toxicity testing of fenugreek seed extracts and moringa leaf extracts (1:1) results in a pseudo value LD50 >4,000 mg/200g bw, therefore we classified the materials to practically non-toxic (PNT). For the subchronic toxicity testing, the result showed a normal state on liver and kidney function.
Efek Ekstrak Campuran Kulit Batang Pulai (Alstonia scholaris) dan Meniran (Phyllanthus niruri) pada Mencit Swiss Webster yang Diinfeksi Plasmodium berghei Intan, Putri Reno; Winarno, M. Wien; Prihatini, Nita
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2949

Abstract

Pulai and meniran is one of the medicinal plants that have been studied as a possible antimalarial drugs. This study aims to evaluate the antimalarial activity of a mixture of pulai bark and meniran extracts as antimalarial drugs. Acute toxicity tests was performed using male and female Wistar rats each 25 animals with four doses of treatment. Antimalarial test using 72 mice were divided into six dose groups: group CMC, DHP, dose mixture of 1330; 443.34; 147.78 mg/kg bw and doses of pulai groups 1330 mg /kg bw. All the mice were infected with Plasmodium berghei (D0) and given the extracts orally for 14 days. Giemsa blood stainning taken on days D1-D7 and D14 were analyzed for percentage of parasitaemia, lymphocytes, monocytes and granulocytes. Results of acute toxicity test (LD50) values obtained from extract mixture was more than 14285 mg/kg bw, are classified as non-toxic materials. The most effective dose of the test antimalarial obtained from the percentage of parasites reducing and leukocytes differential, was 147.78 mg/kg. A mixture of pulai bark and meniran extract can be considered to be used as an alternative drug in the treatment of malaria. Further research is needed to isolate and characterized the active ingredients which have the effect of antimalarial to be recommended as an antimalarial drug in the future.
Pengaruh Pemberian Kombinasi Ekstrak Rumput Mutiara (Hedyotis corymbosa Lamk) dan Meniran (Phyllanthus Niruri L.) terhadap Jumlah AgNOR Jaringan Adenokarsinoma Mammae Mencit C3H Intan, Putri Reno; Winarno, M. Wien
Jurnal Kefarmasian Indonesia VOLUME 4. NOMOR 1 FEBRUARI 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Cancer is one of the non-communicable diseases that has become a health problem in the world, including in Indonesia. Data World Health Organization (WHO) data in 2010 showed that cancer is the second leading cause of death after cardiovascular disease. Mean while, result at Basic Health Research Riset Kesehatan Dasar (Riskesdas) 2007 showed that cancer ranks sixth in the leading cause of death in Indonesia. Number of cancer patients in Indonesia continues to increase and is expected to be the main cause of the increasing economic burden, for the patient, family, and also country. Types of cancer in Indonesia is dominated by breast cancer (30%) cervical cancer (24%). This study aims to determine the effect of a combination of rumput mutiara (Hedyotis corymbosa Lamk) and meniran (Phyllanthus niruri L) against mammary adenocarcinoma in strain C3H mice. This study is an experimental study. The study sample consisted of 20 strains of C3H mice that were divided into 4 groups: control group (K) and three dose groups ( P1 - P3 ), namely : dose 750 ; 1500; 2250 mg/kg BW. Extract of the test material were given after the tumor is palpable, It was given to the mice for 19 days, once a day orally using a stomach sonde. The results of this study indicate that based on the average number of AgNOR mammary adenocarcinoma, the extract at a dose of 2250 mg/kg BW can reduce the proliferation of mammary tumor cells.
Co-Authors Alfred Pakpahan, Alfred Ariffandi, Bagas Intan Sari Oktoberia Kusmardi Kusmardi Lestari, Tri Wahyuni Lubis, Nadar Sukri Lucie Widowati M Wien Winarno M. Wien Winarno Prihatini, Nita Rahmi Febriyanti Rosa Adelina