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Journal : El-Hayah : Jurnal Biologi

Predictive Pharmacological Activity of Galangal Rhizome (Alpinia galanga (L.) Willd.) Through in Silico Analysis as an Effort to Accelerate The Research of Indonesian Medicinal Plants Jamil, Ahmad Shobrun; Ahmad, Mujahidin
El-Hayah : Jurnal Biologi Vol 7, No 4 (2020): EL-HAYAH (VOL 7, NO 4 MARET 2020)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v7i4.10819

Abstract

Indonesia has high biodiversity, especially plant species. There are many benefits that can be Obtained from various plants that grow in Indonesia, one of which is as a health supplement or medicinal raw material. Fast researches are important in the use of these plants so that bio-based products can be widely accepted. One of the important fast methods in analysing the benefits of plant chemical compounds is the in-silico prediction utilizing metadata spread over various pages providing scientific data about plants, their chemical compound content and biological activity. This study was focused on predictively observing the biological activity of the compounds in the rhizome of Alpinia galanga. The research method is by analysing metadata from various sources. Data on the content of chemical compounds can be accessed through the page https://phytochem.nal.usda.gov/, classification of metabolite compounds contained in plants using http://classyfire.wishartlab.com/, prediction of absorption, distribution, metabolism and excretion (ADME) uses http://www.swissadme.ch/, to determine the relationship between plant compounds and body proteins, http://www.swisstargetprediction.ch/ and prediction of cellular mechanisms seen through https://string-db.org. Based on in silico analysis by utilizing some of the above software, it can be seen that the rhizome of the Alpinia galangal plant has 80 active compounds, 47 have high bioavailability and 9 compounds with tight cell proteins. Based on in silico exploration, it is also known that A. galangal has potential as an antioxidant, antimicrobial, anti-cancer and various other pharmacological activities
Co-Authors Ahyana Fitrian, S.Farm. Apt Ahyana Fitrian, S.Farm. Apt, Ahyana Fitrian, Alamsyah, Fakhruddin Almutahrihan, Irsan Fahmi Amaliyah Dina Anggraeni Andika Aliviameita Aris Soewondo Astri Ariani Astri Ariani, Astri Asyhari, Firda Nuri Azka Khoirunnisa Bayu Prasaja Bayu Prasaja, Bayu Buhari Adi, Buhari Buhari Buhari Burhanuddin Burhanuddin Burhanuddin Burhanuddin Dikky Syadqamullah Dina Siti Rahma M. Hentu Dinda Farida Dliyauddin, Moh Dra. Uswatun Chasanah, Apt. Dra. Uswatun Chasanah, Apt., Dra. Uswatun Drs. Ahmad Inoni, Apt Drs. Ahmad Inoni, Apt, Drs. Ahmad Dwi Retno Nur Syahida Eko Budi Cahyono Engrid Juni Astuti Faiznanda Awwaluddin Fakhruddin Alamsyah Fath, Dwi Hanif Muluqul Fitria Dwi Damayanti Hentu, Dina Siti Rahma M. Hidayaturrahman Hidayaturrahman Hidayaturrahman, Hidayaturrahman Hilmy, Fauzan Irsan Fahmi Almuhtarihan Irsan Fahmi Almutahrihan Izuddin Karim Karim, Izuddin Khasna Shafwatul Jihan Lely Mauliana Lena, Nour Lilik Yusetyani Luqman Hakim Luqman Hakim M Artabah Muchlisin M. Artabah Muchlisin M. Artabah Muchlisin M. Helmi Mansur Ibrahim Miftahul Mushlih Moch Sasmito Djati Muchlisin, M. Artabah Muhammad Halim Natsir Mujahidin Ahmad Nabilatul Auliyana Nour Lena Nurul Amalia Azhari Nuryasin, Ilyas Pertiwi, Cinta Junaidi Putri Puspitasari Puspitasari Putri, Nenis Try Melani Rafikayanti, Agustin Resi Puguh Prihantono Rifa’i, Muhaimin Risma Ayu Setiawan Satriawan, Herland Siti Rofida Solly Aryza SRI RAHAYU Sumadi, Firasti Agung Nugrahening Syabana, Nada Laela Syadqamullah, Dikky Thoat Stiawan Tri Luthfiana Maretha Trikxy Viori Andhani Trimianti Hidahyatun Nazah Veda, Adella Infia Helga wahyuni, reni sri Zulfatim, Heni Sukma Zulkipli Hardi Zulkipli Hardi, Zulkipli