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Journal : Strada Jurnal Ilmiah Kesehatan (SJIK)

Mutant p53 Expression Of Oral Transformed Epithelium Cell In Rats Injected By Benzo[A]Pyrene Sawitri Dwi indah Pertami; I Ketut Sudiana; Theresia Indah Budhy; Retno Palupi; Ira Arundina
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 1 (2020): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i1.234

Abstract

Benzopyrene is a polycyclic aromatic hydrocarbons (PAHs) compound that can cause transformation of normal cells into malignant in order to its genotoxic,mutagenic,and carsinogenic ability. DNA mutation in tumor suppressor genes p53 make cells immortal which results in cell transformation and develops into malignancies. This study consist of five groups including the control group (without benzopyrene injection) and 4 treatment groups injected with benzopyrene each for 4 weeks (P1), 6 weeks (P2), 8 weeks (P3) and 10 weeks (P4). Therefore, the mutant p53 expression was calculated and analyzed statistically with the One Way Anova Test. There was signifficance difference in mutant p53 expression of oral transformed epithelium cell injected by benzopyrene (p=0.000) and the highest expression was at 10th week. It can be concluded that the mutant P53 expression of oral transformed epithelium cells in rats was increased after injected by benzopyrene
Co-Authors Adawiyah, Rabi’atul Akhmad Setyo Rahman Alexander Patera Nugraha Amalia, Nadya Rafika Ari Nuswantoro Aryati Aryati Azis, Zulfikran Moh Rizki Bambang Sumaryono Banerjee, Abhishek Bayu Indra Sukmana Budi Santosa Cinantya, Aulia Dian Cyuzuzo Callixte Deddy Hartanto Dominicus Husada Dwicha Rahma Nuriska Hartono Edhi Jularso Edith Frederika Puruhito, Edith Frederika Elizabeth, Laurencia Dwiamanda Erawati Wulandari Fadila, Okta Mulia Nur Firjani, Putri Nabila Fransiskus Andrianto Gustiadi Saputra I Ketut Sudana Indrasari, Yulia Nadar Ira Arundina Islamy, Azzahra Hasnur Jenny Sunariani Jusak A. Nugraha Jusak Nugraha Latief Mooduto, Latief Latifah, Maasyitoh Sari Laurencia Dwiamanda Elizabeth Livesey, Gisele Nefertari Love Masitoh, Hindun Fitria Maulina, Syafriaz Zulfa Ma`ruf, Anwar Muhammad Luthfi Muji Rahayu Nastiti Faradilla Ramadhani Noor, Tengku Natasha Eleena binti Tengku Ahmad Nugraha, Ilyas Yakob Nurul Nur Lailatul Fadhilah Nurwinda Enni Rosyidah Pratiwi, Chandrasasi Berlian Purwaningrum, Vegananda Wahyu Putri, Destiana Hardianti Rahmah, Shafwa Aisha Rahmawati, Septyana Eka Ratri Maya Sitalaksmi Retno Indrawati Roestamadji Retno Palupi Retno Palupi Retno Pudji Rahayu Rezky, Muhammad Andyka Roni Handayani Roni Handayani S.Pd. M Kes I Ketut Sudiana . Salsabila, Alisya Rachel Sari, Arabella Vonia Sawitri Dwi Indah Pertami Setiawan, Kresna Erlangga Shahzad Shoukat Shallomitha, Aginta Gracia Shariff, Khairul Anuar Sisca Meida Wati Sunari, I Gusti Agung Ayu Eka Putri Supandji, Rafaelle Raditya Syahdiar, Aura Zalfa Ghassani Tika, Dian Tuyishimire Irene Vania Syahputri