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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal DIDIKA: Wahana Ilmiah Pendidikan Dasar Educatio Jurnal EDUCATIO: Jurnal Pendidikan Indonesia ALKIMIA : Jurnal Ilmu Kimia dan Terapan Healthy-Mu Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Farmasi dan Sains Indonesia (JFSI) JUKESHUM: Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Sinteza JEC (Jurnal Edukasi Cendekia) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Jurnal Teknologi Informasi untuk Masyarakat (Jurnal Teknokrat) Journal Pharmacy of Tanjungpura
Yuyun Febriani
Universitas Hamzawanwadi
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Jurnal Farmasi dan Sains Indonesia (JFSI)

 1 
VALIDASI METODE ANALISIS SIBUTRAMIN HCL PADA SEDIAAN JAMU PELANGSING DENGAN SPEKTROFOTOMETER UV-VISIBLE Febriani, Yuyun; Izati Savitri, Nurul; Azim, Muhlisun
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p20-30

Abstract

Sibutramine HCl was known as one of the anti-obesity drugs known for its appetite-suppressing properties. The aims of this research were to analyze pharmaceutical chemicals content in slimming herbal remedies available in the East Lombok district market and to analyze the value and validation parameters for analyzing method of sibutramine HCl in these remedies using UV-Visible spectrofotometry. The method used qualitative analysis using thin-layer chromatography (TLC) and quantitative method used spectrophotometry UV-Visible. The method was validated to meet the specified requirements, including linearity, Limit of Detection (LoD), Limit of Quantification (LoQ), precision, and accuracy. The results of this research were, in qualitative analysis, 2 out of 5 samples were identified to contain sibutramine HCl with a value of Rf of 0.78. The selected wavelength for sibutramine HCl analysis was 224.40 nm, and the respective parameters of linearity, LoD, LoQ, precision, and accuracy were (r) 0.9991, 2,406 ppm, 7,291 ppm, 0.446% RSD, and 98.92% recovery. Based on the results above, showed that using the spectrofotometry UV-Visible method in this research complies with the established parameters.
FORMULATION A NATURAL COSMETIC SCRUB OF DURIAN HUSK (DURIO ZIBETHINUS MURR.) AND THE CHARACTERISTIC TESTS) Febriani, Yuyun; Yuliana, Tri Puspita; Hariadi, Puspawan; Gemantari, Baiq Maylinda; Minawati, Minawati
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p25-32

Abstract

The high production of durian fruit gives an environmental problem if it is not used properly. Durian fruit skin contains flavonoids, phenolic compounds, saponins, and tannins which have antioxidant activity. Its antioxidant activity makes durian husk a candidate as a basic ingredient for natural cosmetics. Producing a formulation of scrub preparations as natural cosmetics based on the results of the characteristic test was the purpose in this research. Experimental research with a post-test design technique was carried out by making the changes of the concentration of durian husk as an active ingredient in the scrub preparations used in this study. The form of an oil-in-water cream scrub was used as the formulation in a change of concentration range of 1% (F1), 1.5% (F2), and 3% (F3) for each formula. Furthermore, the characteristic test was carried out which included organoleptic test, homogeneity test. pH test, viscosity test, spreadability test, and adhesion test. In this research also used statistica tests. The results showed that the best formulation is obtained from formulation 3 (F3) with a concentration of 3% durian rind. The characteristic test results include: stable organoleptic test for storage in terms of shape, color and odor; homogeneity test formed granules and there was no separation between the oil and water phases; Stable pH test according to skin pH at 5.05; spreadability test 7.3 cm; viscosity test 64 dPa.s; and 2.41 minutes of adhesion test. It pointed that all formulations fulfilled the requirements for topical scrubs in each characteristic test.
Analisis Aktivitas Antioksidan Pada Fraksi Aktif Kacang Lebui Lombok (Cajanus cajan) Febriani, Yuyun; Habibatusshalihah, Habibatusshalihah
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p78-87

Abstract

Cajanus cajan or known as lebui is one of the local plants of Lombok which is used as a side dish and in some places empirically used as a treatment. This study aims to identify and analyze the antioxidant activity of the active fraction of lebui beans with various solvent variations. The design of post-test was used this study. The extract used was 96% ethanol extract with liquid-liquid fractionation method in various solvents such as methanol, n-hexane, and ethyl acetate. The results obtained were tested by thin layer chromatography with a standard comparison of vitamin C (ascorbic acid) in the eluent composition of ethyl acetate: methanol: formic acid (8:2:0,5). The antioxidant activity test used two tests, namely qualitative testing by spraying DPPH on the TLC plate and quantitative testing using UV-Vis’s spectrophotometer. The TLC test results obtained that the Rf value of lebui bean extract was 0.8, the Rf value for fraction I (n-hexane) was 0.8, the Rf value for fraction II (ethyl acetate) was 0.8, the Rf value for fraction III (methanol) was 0.2 and the standard Rf value for vitamin C was 0.8. The results of the qualitative test showed that fraction I and fraction II contained antioxidants. Further quantitative testing showed that the IC50 value of fraction I (N-Hexane), fraction II (Ethyl Acetate, and standard respectively were 148 ppm, 88.4 ppm, and 48 ppm. Based on this, it can be concluded that lebui beans have antioxidant activity in the category of strong antioxidant activity and more fracted on more polar solvent
Co-Authors Abdul Rahim Anggraini, Virta Dwi Ardyati, Sulistia Arief Rafsanjani Aulia, Amanda Baiq Maylinda Gemantari Baiq Risma Fatmayanti Donna Boedi Maritasari Erma Ewisa Oktresia Habibatusshalihah Habibatusshalihah Habibatusshalihah, Habibatusshalihah Hanifa, Ahdiani Hartini Haritani Husani, Ariqatul Ibrahim, Doni Septu Marsa Ihsan, Ersi Arviana Ikhsan, Ersi Arviana Izati Savitri, Nurul Jeli Marlita Kurniawan, Unhaluddin T. Leny Ramadhan Minawati Minawati Minawati Minawati, Minawati Muhlisun Azim Novasari, Novasari Nur Rezky Khairun Nisaa Nurlaili, Mustika Puspawan Hariadi Risma Hayatun Nufus Siti Nurhaliza Taherong, Rosmawati Tri Puspita Yuliana Wazni, Annisa Rizqita