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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

Cholangiocarcinoma: A Comprehensive Review and Update Guideline Nugraha, Kadek Nandita; Hardyningrat, Baiq Inna Dwi; Kirana, Devi Chandra; Yahya, Najla Aulia; Ishlahi, Salsabila Dinda Nuril; Kadarisma, Shofia; Djannah, Fathul
Jurnal Penelitian Pendidikan IPA Vol 10 No 10 (2024): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i10.8419

Abstract

Cholangiocarcinoma is a rare cancer of the gastrointestinal system. However, the prognosis for people with this disease has not improved in the last decade. CCA has a poor prognosis because most cases are diagnosed at an advanced stage and the availability of treatment options is limited.  This literature review aims to provide information regarding the current understanding and guidelines for cholangiocarcinoma. In this literature review, we searched the National Center for Biotechnology Information (NCBI) and Google Scholar using the search keywords "Cholangiocarcinoma", "cholangiocarcinoma management", "cholangiocarcinoma guidelines" taken ScienceDirect, Researchgate, National Comprehensive Cancer Network, and PubMed published in the last 10 years. From various databases, the literature used and according to the selection criteria amounted to 50 articles In the latest articles and the Cancers NCCN Guidelines for Biliary Tract Cancer in 2023, CCA treatment is carried out based on the patient's profile. Targeted therapy is an additional treatment option today by targeting the molecular profile involved in the pathogenesis of CCA. The diagnosis of cholangiocarcinoma is made through histology, radiography, and laboratory examination. Based on the Cancers NCCN Guidelines for Biliary Tract Cancer in 2023, the treatment carried out consists of determining cancer staging, surgery, radiation therapy, and systemic therapy.
Histopathological Features and Diagnosis of Breast Cancer Sepestian, Ghina Shadrina Rienti; Djannah, Fathul
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.8469

Abstract

In Indonesia, the high number of breast cancer cases is not always followed by complete clinical and histopathological determination, even though clinical and histopathological staging is needed to determine the diagnosis and further management. Breast cancer is a malignant mass originates from the uncontrolled division of cells in breast tissue Breast cancer or mammary carcinoma is a lump that grows and develops abnormally in the cells and tissues located in the breast, such as the fat tissue and connective tissue in the breast, ducts and lobules. The histopathological examination procedure is that the patient must undergo a biopsy. Biopsy results can be used to diagnose breast cancer and also monitor the success of therapy. Mammary carcinoma can spread to surrounding tissue or to other organs through blood vessels. Breast cancer is the most common cancer in Indonesia. The prognosis of breast cancer is determined by the 5 years survival rate. The survival rate for cancer sufferers in Indonesia is low compared to other developing countries, namely 51.07%. This research is in the form of a literature review with 14 papers as references. The results obtained were that invasive ductal carcinoma was the most common mammary carcinoma and grade II-III was found to be the dominant grade.
Etiopathogenesis in Neuropsychological Aspects of Mood Disorders and Self-Harming Behavior in Adolescents: A Review Agestia, Mayumi; Djannah, Fathul
Jurnal Penelitian Pendidikan IPA Vol 10 No SpecialIssue (2024): Science Education, Ecotourism, Health Science
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10iSpecialIssue.8643

Abstract

The average prevalence of self-harm in school-age adolescents in the world is 17.20% with bipolar spectrum disorders (37%) apparently higher than among adolescents with depressive disorders (13%). Based on etiopathogenesis, neuropsychological factors are associated with the emergence of mood disorders and self-harm behavior. The method used is the preparation of this article review was carried out through the process of searching, collecting data, and analyzing several articles from Science Direct, Proquest, Pubmed, and Google Scholar. The extracted data were analyzed to summarize the findings related to the etiopathogenesis of mood disorders and self-harm behavior in adolescents reviewed from a neurophysiological aspect. Discussion: Based on the results of the analysis of several articles, the etiopathogenesis of mood disorders and self-harm behavior in adolescents reviewed from a neurophysiological aspect is related to the influence of neurotransmitters and changes in the functional structure of the brain. The related neurotransmitters are serotonin, dopamine, GABA, glutamate, norepinephrine, and histamine. In adolescents who are not accompanied by psychological maturity, it can cause conflicts that result in emotional stress and distress as well as the emergence of negative emotions related to changes in brain function and structure related to brain neuroplasticity and disruption of the reward and punishment system in the limbic system.